HI KIM & JOYCE!!!!
I am from BC as well, and had responded to your previous post about where to get LDN compounded locally.
Are you in the Vancouver area? Did you find a reputable pharmacy, experienced in LDN? If so, I wouldn't mind knowing who it is as I am only aware of one local pharmacy that has experience with LDN capsules (I'm currently on liquid). You can email me if you prefer, at "firstname.lastname@example.org".
I felt awesome the first two weeks of LDN. I am still feeling fantastic, but have noticed a bit more fatigue and some numbness sneak back in over the last few days. For me, it may either be a result of using liquid LDN (shelf-life or suspension); additional stress lately; the need to increase to 4.5mg... OR . . . please see the attached comments regarding the changes that may occur in the first 3 month:
For those of you in the first 3 months of LDN therapy Dr. Bob Lawrence from the UK who has MS & uses LDN himself explains why the temporary increase in MS symptoms...
This temporary increase in symptoms may also perhaps be explained when we consider the manner in which this drug is expected to work.
Initially, MS occurs due to a reduction in the activity of the controlling influence of the suppressor T-cells within the immune system. During an acute relapse, the overall number of T-cells is reduced, the normal balance of helper T-cells and suppressor T-cells is disrupted and the damaging helper (CD-4) T-cells tend to predominate. This is the situation most pronounced during an acute relapse but occurs similarly, but to a lesser extent, in chronic progressive MS.
Under the influence of LDN there will be an expected increase in the overall numbers of T-cells but, because the CD-4, helper T-cells tend to predominate at this time, an increase in their numbers will expectedly tend to increase MS symptoms. It is only when the numbers of suppressor T-cells effectively "catch up" that the normal balance is restored and symptoms once again diminish and improve.
In addition, because LDN stimulates the immune system and many of the drugs routinely used by the NHS in the treatment of MS further suppress the immune system, LDN cannot be used in company with steroids, beta interferon, methotrexate, azathioprine or mitozantrone or any other immune suppressant drug.
If there is any doubt, please submit a full list of the drugs you are presently taking so that their compatibility may be assessed. In addition, because LDN will also block the analgesic effects of any opiate drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine) presently being taken, the use of LDN will initially greatly increase the level of pain experienced.
It is therefore advisable that any opiate-like drugs be discontinued at least two weeks before this treatment is initiated. When starting the treatment it is essential that any untoward or adverse side-effects are reported immediately so that the treatment process can be further assessed and, if necessary, modified.
Dr. M R Lawrence
<div><span class="postbody">''In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.'' </span><span cla