New use in diet pill

A board to discuss Low Dose Naltrexone (LDN) as a treatment for Multiple Sclerosis

New use in diet pill

Postby lyndacarol » Wed Dec 08, 2010 9:04 pm

The big news today seems to be that an FDA advisory panel is positive about a new diet drug:

http://online.wsj.com/article/BT-CO-20101208-714967.html

The mention of naltrexone caught my eye:
Contrave, which is being developed with Takeda Pharmaceutical Co. (TKPYY, 4502.TO), is a combination of two drugs already on the market, addiction-treating naltrexone and the antidepressant bupropion, commonly known by the brand name Wellbutrin. Orexigen argued that Contrave's ingredients have been on the market for 20 years and haven't shown major cardiovascular-safety problems.


Interesting, don't you think?

I heard one doctor ascribed the ability of Contrave to reduce weight to the fact that naltrexone boosts metabolism. Now I wonder if naltrexone, by boosting the metabolism and burning more glucose, thereby reducing insulin, has its positive effect on MS. In the same manner, exercise would have its positive effect also.
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Re: New use in diet pill

Postby NHE » Mon Dec 20, 2010 3:42 am

lyndacarol wrote:The big news today seems to be that an FDA advisory panel is positive about a new diet drug:

http://online.wsj.com/article/BT-CO-20101208-714967.html

The mention of naltrexone caught my eye:
Contrave, which is being developed with Takeda Pharmaceutical Co. (TKPYY, 4502.TO), is a combination of two drugs already on the market, addiction-treating naltrexone and the antidepressant bupropion, commonly known by the brand name Wellbutrin. Orexigen argued that Contrave's ingredients have been on the market for 20 years and haven't shown major cardiovascular-safety problems.


Interesting, don't you think?

I heard one doctor ascribed the ability of Contrave to reduce weight to the fact that naltrexone boosts metabolism. Now I wonder if naltrexone, by boosting the metabolism and burning more glucose, thereby reducing insulin, has its positive effect on MS. In the same manner, exercise would have its positive effect also.


Could it also have something to do with sugar's effect on the brain? Sugar is known to stimulate the addiction centers in the brain.

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Postby CD » Fri Dec 24, 2010 11:45 pm

I had the CCSVI procedure, but can't wait until I can get back on my LDN. It helped me so much these last few years. I had to stop it more than 72 hours before the procedure so that the pain and/or light sedation medication would work.

I hope it doesn't end up costing more, like they did with 4-AP (Ampyra SR). I don't take either, but they raised the cost almost 70 times the compounded price, that has been around for ages.
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Re: New use in diet pill

Postby Thekla » Sun Apr 01, 2012 7:43 am

I read that there are components in modern wheat that bind to those opioid receptors that naltrexone blocks in the brain. This causes wheat products to be 'comfort' foods that make us want to keep eating more. Blocking the receptors with naltrexone, blocks the desire for more, hence the diet pill idea. (The research was mentioned in the book Wheat Belly which is available on amazon) The mention of naltrexone made me sit up and take notice! Maybe the new 'diet pills' will be available otc in Germany! I don't know the dosage of naltrexone in them but LDN is a pain to get here. Customs has already confiscated some since it is not an 'approved' medication.
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