I happened upon some info on endorphins at this site http://www.enneagramcentral.com/pharm_9a.htm
when I was looking for info on endorphin levels. Here's a couple things from this article:
The body produces its own endogenous narcotics in the brain pharmacologically known as Endorphins. (Remember my essay on Point Three). Although Endorphins are not chemically related to morphine, being a number of chemically linked amino acids, they act pharmacologically the same way. They relieve pain, producing a sort of euphoria and reducing stress.
There is a medication known as Naltrexone. It blocks the action of opiates such as Morphine on the brain centers and is orally active. It comes in 50 mg tablets and is used in cases of narcotic addiction to prevent the addict from obtaining a "high". It is also used in scientific experiments to block the action of Endorphins, the natural brain opiates.
Endorphins have an effect on the immune reactions, usually acting as an immunodepressant and the decrease in the activity of the immune system in rats put under stressful conditions was believed to be due to increased endorphin secretion in the stressed out rats. This was proven by giving the rats Naltrexone before the stress. When under the influence of the Endorphin inhibiting Naltrexone, the stress applied to the rats did not decrease the efficiency of there immune system.
Naltrexone has recently been approved for the treatment of alcoholism. By taking a 50mg Naltrexone tablet daily, an alcoholics craving for alcohol seems to be reduced. The reason for this is believed to be that part of the pleasant euphoric effect of alcohol is due to an increased stimulation of Endorphin secretion in the brain. Trexan (the brand name for Naltrexone) will block some of the alcohol induced pleasure by inhibiting Endorphin action.
So does LDN actually decrease endorphin secretion like it's big brother Naltrexone there by giving the immune system a boost or increase the amount of endorphins and act as a immunodepressant?