A promising treatment in immune-related diseases and cancer

A board to discuss Low Dose Naltrexone (LDN) as a treatment for Multiple Sclerosis

A promising treatment in immune-related diseases and cancer

Postby Petr75 » Sat Jun 30, 2018 1:05 pm

2018 Jun 6
Shengjing Hospital of China Medical University, China
Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy. https://www.ncbi.nlm.nih.gov/pubmed/29885638

Naltrexone, a non-selective antagonist of opioid receptors, is mainly used as rehabilitation therapy for discharged opiate addicts to eliminate addiction in order to maintain a normal life and prevent or reduce relapse. In recent years, there have been some novel and significant findings on the off-label usage of naltrexone. Within a specific dosage window, LDN can act as an immunomodulator in multiple autoimmune diseases and malignant tumors as well as alleviate the symptoms of some mental disorders. The results of increasing studies indicate that LDN exerts its immunoregulatory activity by binding to opioid receptors in or on immune cells and tumor cells. These new discoveries indicate that LDN may become a promising immunomodulatory agent in the therapy for cancer and many immune-related diseases. In this article, we review the pharmacological functions and mechanisms of LDN as well as its clinical therapeutic potential as revealed by our team and other researchers.
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Re: A promising treatment in immune-related diseases and can

Postby NHE » Sun Jul 01, 2018 1:26 am

At least the publishers gave us one of the paper's figures.

https://www.sciencedirect.com/science/a ... via%3Dihub

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