I have no personal experience with LDN but looked on PubMed for association with rhabdomyolysis and naltrexone. I found one reported instance of a possible association you could share with your doctor if you want - in this case, note the patient was receiving a much higher dose, 50 mg/day, for treatment of alcohol dependence.
Other than this, I didn't see much else on PubMed for naltrexone, so based on that, I don't see very strong evidence of an association compared to what is published on other drugs. It is also worth noting that people taking naltrexone for drug dependence have effects on their bodies from addiction and possible other health effects like infections.
Like you noted, rhabdomyolysis has been associated with a variety of other drugs, including antidepressants and statins. I've also personally known people have developed it after having the flu.
Are you taking anything else besides LDN? Hope the ck levels go back down, whatever is causing the elevation....
Here's the abstract.....
1: Ann Pharmacother. 1999 Mar;33(3):312-3. Links
Rhabdomyolysis associated with naltrexone.Zaim S, Wiley DB, Albano SA.
Division of Cardiology, Brooklyn Veterans Affairs Hospital, NY, USA.
OBJECTIVE: To report a possible association between naltrexone therapy and the development of rhabdomyolysis in one patient. CASE SUMMARY: A 28-year-old white man in good physical health was started on naltrexone 50 mg/d for inpatient treatment of alcohol dependence and depression. A routine serum chemistry panel obtained on day 9 of naltrexone therapy showed marked new elevations in creatine kinase and aspartate aminotransferase. The patient remained asymptomatic and did not develop renal insufficiency. The serum enzyme concentrations returned to normal within eight days of naltrexone discontinuation. DISCUSSION: Rhabdomyolysis has not been previously reported to occur in patients during treatment with naltrexone. Alcoholism may result in a reversible acute muscle syndrome, but our patient did not fit the appropriate clinical profile for such a syndrome. Additionally, the other prescribed medications could not be implicated as possible causative agents. CONCLUSIONS: This case report illustrates a possible association between naltrexone therapy and rhabdomyolysis.
PMID: 10200856 [PubMed - indexed for MEDLINE]