Hi, LindaR. You would need to ask a doctor about that, but I know of several people on many different kinds of antidepressants that started LDN, so odds are, it won't be a problem. But you should always make sure! I've also heard of alot of people who no longer needed their antidepressants once they started LDN.
My son suffered from severe depression while using Avonex and Rebif, but has not had any problems with depression since starting LDN in June of this year.