2015 clinical trial: zinc for depression in MS

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2015 clinical trial: zinc for depression in MS

Postby jimmylegs » Fri Nov 23, 2018 5:44 am

Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial (2015)

"Abstract
Introduction
Major Depressive Disorder (MDD) is known as one of the most common psychiatric disorders in patients with multiple sclerosis (MS). In recent years, zinc has been found to have beneficial effects on psychopathology and the therapy of depression. The aim of the present study was to examine the effect of zinc supplement on depression and neurological signs in patients with MS.

Methods
The present randomized, double-blind, placebo-controlled clinical trial was performed on 43 patients with MS and who also demonstrated MDD based on the Beck questionnaire. These patients were randomly selected and were divided into two groups: the placebo group (n = 22) and the intervention group (n = 21). The patients received either zinc sulphate (220 mg containing 50 mg zinc element) or a placebo for 12 weeks. Clinical examinations were obtained in terms of abnormal ocular movement, muscle power, and gait disorder.

Results
The results indicated that in the patients who received the zinc supplement, the mean score of depression was reduced compared to those in the placebo group, whereas the neurological examinations revealed that there were no differences between the treatment and control groups.

Conclusion
Therefore, the zinc supplementation is an appropriate choice for the depression management in patients with MS."


it would be interesting to have seen the serum zinc levels in the case and control groups before and after this treatment.

the results reported in this small trial seem consistent with some elements of my own experience with zinc deficiency and repletion. zinc repletion eradicated years-long cognitive deficits that were most logically the consequence of a very long term vegan diet. i used to have no short term memory whatsoever. perfectly fine now. it's weird but good to be able to recognize cognitive red flags, realize nutrient status likely needs some attention, and act to restore nutrient status and associated function.

cognitive measures aside, the other thing which resolved after zinc repletion was my stubborn 'ms average' uric acid level. i think it was all interconnected - low zinc, broken krebs cycle, ammonia toxicity, brain damage.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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Re: 2015 clinical trial: zinc for depression in MS

Postby jimmylegs » Fri Nov 23, 2018 11:07 am

also essential nutrient deficiency models used to trial antidepressant meds REALLY PISS ME OFF

Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex (2015)
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 11779
Joined: Sat Mar 11, 2006 3:00 pm


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