new biomarkers of disease progression linked to cholesterol

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new biomarkers of disease progression linked to cholesterol

Postby frodo » Thu May 18, 2017 12:34 am

It seems that the Simvastatin connection is under research by the groups that investigate pathogenesis, and they have found that some cholesterol-associated levels can be used also to monitor progression

Extending lipid biomarkers of disease progression in people with multiple sclerosis
http://www.neurology.org/content/88/16_ ... .345.short

Conclusions: We identified associations between novel cholesterol subsets and plasma triglycerides and EDSS in MS patients that are independent of age and sex. These could discriminate disease ‘state’ with high specificity and sensitivity.
Last edited by frodo on Fri May 26, 2017 6:11 am, edited 1 time in total.
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Re: new biomarkers of disease progression linked to choleste

Postby frodo » Fri May 26, 2017 6:10 am

just to make explicit the relationship, I will post here some results and expectations of Simvastatin:

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more about biomarkers

Postby frodo » Sat Jun 17, 2017 7:06 am

More about biomarkers

Source: http://www.jimmunol.org/content/198/1_Supplement/55.23

... We developed in a training cohort ... two biomarker-based classifiers that differentiate:

1. MS from CNS diseases that mimic MS clinically, pathophysiologically and on imaging, and
2. relapsing-remitting from progressive MS with ~90% accuracy.

Treatment-induced changes in biomarkers greatly exceeded intra-individual-and technical variabilities of the assay.

The observation that CNS biological processes reflected by combinatorial CSF biomarkers are robust, stable and disease- or even disease-stage specific opens opportunities for broad utilization of CSF biomarkers in drug development and precision medicine for CNS disorders.
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