lack of a micro-RNA as a biomarker

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lack of a micro-RNA as a biomarker

Postby frodo » Sat Dec 09, 2017 4:59 am

MicroRNAs are proposed as a biomarker of MS. When myelin is broken, some fragments of RNA appear in blood.

But a recent research has appeared pointing to the opposite. A microRNA (miR-219) normally present in controls, which is involved in the normal funtion of oligodendrocytes, is lacking in MS patients

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS

Source: https://jneuroinflammation.biomedcentra ... 017-1006-3


Conclusions

We have been able to identify and validate absence of miR-219 detection in CSF of MS patients compared to controls, suggesting that it may emerge as a candidate biomarker for MS diagnosis.
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