Finally a biomarker

A forum to discuss research on the origins of MS and its development.

Finally a biomarker

Postby frodo » Sun May 20, 2018 12:15 pm

It seems that they have found finally a biomarker for MS. Previously light chains (pieces of immunoglobulins in blood) had been reported that could be used. Now this people says that they can be improved comparing it with CSF. They have made the news in some neurology specialized journals (http://jnnp.bmj.com/content/early/2018/ ... 18326.full)

They have predicted CIS to MS conversion, which translated to English means that they can make a difference between a non-MS attack and a real MS attack as soon as it happens.

Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis.

http://jnnp.bmj.com/content/early/2018/ ... 018-317947

Abstract

Objective To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts.

Methods CSF and peripheral blood were obtained from patients undergoing elective diagnostic lumbar puncture and included clinically isolated syndrome (CIS) (n=43), relapsing remitting MS (RRMS; n=50), primary progressive MS (PPMS; n=20) and other neurological disease controls, both inflammatory (ONID; n=23) and non-inflammatory (OND; n=114). CSF samples were assayed for free and immunoglobulin-associated light chains and on B cells and plasmablasts. Clinical follow-up data were collected during a 5-year follow-up period where available.

Results There was an increased median CSF κ:λ free light chain (FLC) in all MS groups (CIS: 18.2, 95% CI 6.8 to 30.3; RRMS: 4.4, 95% CI 2.7 to 11.4; PPMS: 12.0, 95% CI 3.6 to 37.1) but not controls (OND: 1.61, 95% CI 1.4 to 1.9; ONID: 1.7, 95% CI 1.3 to 2.2; p<0.001). This ratio predicted Expanded Disability Status Scores (EDSS) progression at 5 years, with a lower median EDSS in the group with high (>10) CSF κ:λ FLC (0.0, 95% CI 0 to 2.5 vs 2.5, 95% CI 0 to 4, high vs low; p=0.049). CSF κ:λ FLC correlated with CSF IgG1 κ:λ (r=0.776; p<0.0001) and was intrinsic to CSF plasmablasts (r=0.65; p=0.026).

Conclusions These data demonstrate that CSF immunoglobulin κ:λ ratios, determined at the time of diagnostic lumbar puncture, predict MS disease progression and may therefore be useful prognostic markers for early therapeutic stratification.
Last edited by frodo on Tue May 22, 2018 7:47 am, edited 1 time in total.
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Re: Finally a biomarker

Postby NHE » Mon May 21, 2018 12:09 am

frodo wrote:It seems that they have found finally a biomarker for MS. Previously light chains (pieces of DNA in blood) had been reported that could be used.

I believe that the term 'light chains' is referring to protein. Immunoglobulins are antibodies. They are composed of two heavy chains and two light chains. See... http://www.biology.arizona.edu/immunolo ... cture.html and the following diagram depicting the 3D beta sheet structure... https://en.wikipedia.org/wiki/File:Antibody_IgG2.png
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Re: Finally a biomarker

Postby frodo » Tue May 22, 2018 7:46 am

NHE wrote:I believe that the term 'light chains' is referring to protein. Immunoglobulins are antibodies. They are composed of two heavy chains and two light chains. See... http://www.biology.arizona.edu/immunolo ... cture.html and the following diagram depicting the 3D beta sheet structure... https://en.wikipedia.org/wiki/File:Antibody_IgG2.png


You're right. I was thinking of other thing ... corrected.
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