How B-cells produce MS

A forum to discuss research on the origins of MS and its development.

How B-cells produce MS

Postby frodo » Tue Jun 26, 2018 3:10 am

For most of the authors is not an issue anymore if B-cells are the cause of MS. The question is how they produce MS. Here there is a fully available review.

Reassessing B cell contributions in multiple sclerosis

https://www.nature.com/articles/s41590-018-0135-x

Abstract

There is growing recognition that B cell contributions to normal immune responses extend well beyond their potential to become antibody-producing cells, including roles at the innate–adaptive interface and their potential to modulate the responses of other immune cells such as T cells and myeloid cells. These B cell functions can have both pathogenic and protective effects in the context of central nervous system (CNS) inflammation.

Here, we review recent advances in the field of multiple sclerosis (MS), which has traditionally been viewed as primarily a T cell–mediated disease, and we consider antibody-dependent and, particularly, emerging antibody-independent functions of B cells that may be relevant in both the peripheral and CNS disease compartments.

User avatar
frodo
Family Elder
 
Posts: 1149
Joined: Wed Dec 02, 2009 3:00 pm

Advertisement

Return to MS Etiology and Pathogenesis

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service