Dysregulated EBV infection in MS. Old but relevant.

A forum to discuss research on the origins of MS and its development.

Dysregulated EBV infection in MS. Old but relevant.

Postby frodo » Sun Jul 22, 2018 6:18 pm

They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

http://jem.rupress.org/content/204/12/2899?papetoc=

Abstract

Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS), but direct proof of its involvement in the disease is still missing. To test the idea that MS might result from perturbed EBV infection in the CNS, we investigated expression of EBV markers in postmortem brain tissue from MS cases with different clinical courses.

Contrary to previous studies, we found evidence of EBV infection in a substantial proportion of brain-infiltrating B cells and plasma cells in nearly 100% of the MS cases examined (21 of 22), but not in other inflammatory neurological diseases. Ectopic B cell follicles forming in the cerebral meninges of some cases with secondary progressive MS were identified as major sites of EBV persistence. Expression of viral latent proteins was regularly observed in MS brains, whereas viral reactivation appeared restricted to ectopic B cell follicles and acute lesions.

Activation of CD8+ T cells with signs of cytotoxicity toward plasma cells was also noted at sites of major accumulations of EBV-infected cells. Whether homing of EBV-infected B cells to the CNS is a primary event in MS development or the consequence of a still unknown disease-related process, we interpret these findings as evidence that EBV persistence and reactivation in the CNS play an important role in MS immunopathology.
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Re: Dysregulated EBV infection in MS. Old but relevant.

Postby CureOrBust » Wed Jul 25, 2018 4:30 am

frodo wrote:They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??
....
the study wrote:we interpret these findings as evidence that EBV persistence and reactivation in the CNS play an important role in MS immunopathology.

One groups evidence does not constitute proof.

And others have commenced EBV specific trials, which have research way before these guys.
see: drug-pipeline-f13/topic30179.html
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Re: Dysregulated EBV infection in MS. Old but relevant.

Postby jimmylegs » Wed Jul 25, 2018 6:46 am

my 2c: correlation vs causation. i have limited but lab documented evidence of reducing both EBV viral load and food sensitivities (n=1, but not me) with an emphasis on nutrient repletion (as opposed to normalcy). scientific evidence specific to EBV and nutrition is thin at present, but not to infection in general.

A case of mononucleosis in an anorexic patient with zinc deficiency
http://www.mattioli1885journals.com/ind ... /view/3586
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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