OCB negative MS - immunogenetically distinct

A forum to discuss research on the origins of MS and its development.

OCB negative MS - immunogenetically distinct

Postby frodo » Sun Jul 22, 2018 7:22 pm

Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct

http://n.neurology.org/content/67/6/106 ... ticle-info

Abstract

We sought to determine whether Swedish patients with multiple sclerosis (MS) with and without oligoclonal bands (OCBs) in the CSF constitute distinct subpopulations, clinically and immunogenetically. Our findings indicate that OCB-negative MS shares the same clinical features as OCB-positive MS regarding female predominance, age at onset, proportion of primary progressive cases, rate of MRI positivity, and disease severity. Our HLA-DRB1 genotyping results suggest, however, that OCB-positive and OCB-negative MS are immunogenetically distinct.
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