Lesions evolution under PET

A forum to discuss research on the origins of MS and its development.

Lesions evolution under PET

Postby frodo » Mon Jul 23, 2018 10:50 am

PET (Positron imaging technology) is a imaging method able to show the molecular structure of a lesion.

Several radioligands, compounds that work as a contrast in PET, have been used. Currently the new genereation is able to show how lesions are produced.

Some quotes:

In vivo TSPO-PET imaging has revealed modest microglial activation in the NAWM of RRMS patients, when compared to SPMS (46). Similarly, in neuropathological studies, the diffuse microglial activation outside focal lesions was a feature of progressive disease and was less significant in RRMS patients ...ç

The greatest potential for TSPO-PET imaging over conventional MRI lies in its ability to detect the diffuse compartmentalized inflammation related to microglial activation, and there are expectations for the usability of PET imaging in the quantification of treatment effects of MS drugs targeting microglial activation....

https://www.frontiersin.org/articles/10 ... 00181/full
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