all things vitamin D

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Postby daverestonvirginia » Mon Jun 30, 2008 9:16 am

I have gone up to 6,000 iu's a day in the winter months.
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Postby GeoGuy » Mon Jun 30, 2008 7:06 pm

Thanks for your input, I really appreciate it. I get more than 15 minutes of sun a day while I wait outside for the bus every weekday, so I don't think just exposure to the sun will be enough. During summers here in North Carolina it can be tough to balance sun exposure and staying out of the heat and humidity.

I'm not sure what level is considered low. I should have asked for specifics and will when I go back mid-August for more testing. I'll let you know.

Jack
RRMS since 01/07.
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Postby jimmylegs » Tue Jul 01, 2008 6:13 am

hi GG, cutaneous production will be less if you are covered with clothing, darker skinned, and/or deeply tanned. if you can find a way to get some lighter parts exposed without getting in trouble, that might help some.

do find out what low is though, it would be good to know. i had been supplementing for some time when i got my first test and it was only 72. the docs would have said that was fine but by that time i had a stack of literature that supported a different view. 72 might be okay for preventing osteoporosis, but for immune health, gotta be higher. the intended boost of 50 nmol/L from that high octane liquid i took ended up being more like 75 since i got up to 149 but i've never been that high since and i was back down in the 70s at my last test. i'm not getting enough sun either so i should probably try to make a point of it.

by the way my units are in metric but there is a conversion site called SI Units for Clinical Data and vitamin D3 is at the bottom.

http://www.unc.edu/~rowlett/units/scale ... _data.html
Vitamin D
25-Hydroxyvitamin D ng/mL 2.496 nmol/L

which i take to mean you divide my numbers by 2.496 to get values in ng/mL.
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Postby jimmylegs » Tue Jul 01, 2008 6:28 am

oh i just re-read about the heat and humidity, that must make it tougher for sure.

the literature advises that the body uses 4000IU per day. one would hope some of that comes from food. maybe with your 2000IU plus food, you were only getting enough for a small boost. so 3000IU will surely make it climb faster.

if you find out what your numbers are, there is a paper out there which lets you calculate how much you need to take for your body weight in order to reach your desired level of vitamin D in a specified time.

i had used it to figure out it would take months and months for me to make it from 72 to where i wanted to be, which i why i started asking questions and found out from the hospital about the 50,000IU x 10d idea.

it was the pharmacist that looked up the specific product i ended up with. first he handed me a bottle of 50,000IU pills, but they turned out to be D2, so then he went to his product tome and found the intense liquid D3, which is what i used. i have a prescription for it right now but i thought hey, it's summer - turns out i'm spending so much time writing on the computer i should probably just take it.

but do take care when you up your D3 intake, to balance with calcium and magnesium. i think the best bet diet recommends 1200mg calcium and 600-1200mg magnesium. i certainly didn't take enough and i think that's why my throat got so bad, and why the magnesium fixed it so quickly.

personally, when i tried to up my minerals to match my 4000 d3, it made my back hurt. kidneys didn't like it, is what i thought. next time, i might try the cal-mag mix the other way around, with 1 cal to 2 mag. will report on how this strategy works out, in regimens under Mega D :)
cheers

hope that helps!
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Vitamin D Supplementation in the Fight Against MS

Postby Nick » Mon Jul 07, 2008 6:27 pm

Below is an article writen by Ashton Embry for the New Pathwaysmagazine's January, 2008 edition.

Cheers
Nick

Vitamin D Supplementation in the Fight Against MS


On the 28th December 2007, vitamin D made Time magazine’s top 10 list of medical breakthroughs for that year, after a twelve month period in which the solid scientific support for the linkage with Multiple Sclerosis grew considerably.

When this latest information, summarized below, is combined with all the previous work it essentially leaves very little doubt that MS is a long latency vitamin D deficiency disease. Once this is accepted then it becomes obvious that adequate vitamin D intake from birth onward can protect a person from MS regardless of genetic susceptibility or exposure to other environmental factors involved in MS.

A year ago researchers at Harvard University (Munger et al) compared vitamin D levels in stored, blood samples of soldiers later diagnosed with MS to vitamin D levels of matched, healthy controls. This work demonstrated that “the risk of multiple sclerosis significantly decreased with increasing levels of 25 hydroxvitamin D” (the form of vitamin D which circulates in the blood). Furthermore, the researchers found that this correlation “was particularly strong for vitamin D levels measured before age 20”. Harvard researchers led by Alberto Ascherio followed up this paper with a comprehensive review article on environmental risk factors for MS and the evidence linking vitamin D to MS covered 5 pages. At the same time, George Ebers of Oxford University co-authored a major review paper on environmental causes of MS and pointed to vitamin D as one of the main factors. When researchers at two of the top universities in the world are touting vitamin D as a significant causal factor of MS in mainstream medical journals, you know that the concept is finally being taken seriously by the MS research establishment some 33 years after it was first proposed.

A study of regional differences in MS prevalence for French farmers was published in April 2007 by Vukusic et al. It is clear that the differences in MS prevalence, which are over two fold, are readily explained by variations in ultraviolet radiation/vitamin D supply over France. Such an interpretation is hard to challenge because genetics is not a confounding factor and the farmers are distributed evenly throughout the country. Additional convincing evidence of the MS/vitamin D linkage was provided by a study of childhood sun exposure and MS risk of identical twins in North America by Islam et al. The results demonstrated that “the risk of MS was substantially lower for the twin who spent more time suntanning in comparison with the co-twin”.
A third study by Kampman et al. looked at the risk of MS and differences in outdoor activities and diet of children and adolescents born and living in northern Norway. They found that increased outdoor activities in early life as well as cod liver oil supplementation were associated with a lower risk of MS. I would emphasize that these three, solid studies from different parts of the world all strongly support the concept that the higher one’s supply of vitamin D, the lower the risk of MS.

Also of importance were three other studies published in 2007, all of which looked at vitamin D status and disability in persons with MS. Van der Mei et al measured vitamin D levels in persons with MS in Tasmania and found that “increasing disability was strongly associated with lower levels of 25(OH)D (circulating vitamin D) and with lower levels of sun exposure”. In Finland, Soilu-Hanninen et al demonstrated that, for MS patients, there was “an inverse relationship between serum vitamin D levels and MS clinical activity”. Finally Woolmore et al in a British study found that there was an association between skin type and disability in female MS patients. Those with sun-sensitive skin types, which produce vitamin D faster, had lesser disability. These studies all point to the same conclusion that increased vitamin D, lessens disease progression and resulting disability.

Another key paper published in 2007 was that by Holmoy who came to the same conclusion I had in my 2004 paper on MS causal factors. He interpreted that adequate vitamin D in childhood prevents MS by regulating the immune system such that it does not produce myelin-sensitive immune cells during and after infections with childhood viruses such as Epstein-Barr. To me, this is by far the simplest and most reasonable explanation of how adequate vitamin D ensures MS does not develop in later life.

Perhaps the most important paper on vitamin D published in 2007 did not address MS but cancer. Lappe et al convincingly demonstrated with a 4 year, double blind, clinical trial involving over 1000 post-menopausal women that supplementing with 1000 IU of vitamin D reduced all-cancer risk by a very impressive 60%. One can only wonder what the result would have been with an adequate supplement of 4000-5000 IU. In terms of MS, cancer prevention is a welcome “side effect” of maintaining adequate vitamin D levels

The last publications I’ll mention deal with safety issues. A study by Hathcock et al provided clear evidence that an intake of 10,000 IU of vitamin D per day is perfectly safe and that such an amount should be adopted as the safe upper limit for vitamin D intake. Kimball et al showed that up to 40,000 IU a day did not result in any adverse side effects.

Given all the evidence which ties vitamin D to MS onset and progression and the recent data on the safety of 10,000 and perhaps as much as 40,000 IU/d, I would strongly recommend persons with MS consider using 6000 IU/d as an adequate supplement. This will ensure their circulating 25D level will always be in the 125 -200 nmol/l range and such a level may well have significant benefit. Furthermore I would recommend that all first degree relatives of persons with MS maintain a 25D level of at least 100 nmol/l and preferably closer to 150 nmol/l.


Ashton Embry PhD
http://www.DIRECT-MS.org



Vitamin D Supplementation in the Fight Against MS(cont’d).


Online Presentations.

The Vitamin D Pandemic and its Health Consequences
Presented by Michael Holick, PhD, MD, Professor of medicine, physiology and biophysics and director of the General Clinical Research Center at Boston University Medical Center. (Keynote address at the opening ceremony of the 34th European Symposium on Calcified Tissues, Copenhagen 5 May, 2007)
http://www.vitamind-holick.ms-diet.org/


Prospects for Vitamin D Nutrition
Presented by Rheinhold Veith, associate professor of nutritional sciences and pathobiology and laboratory medicine, University of Toronto.
http://www.vitamind-veith.ms-diet.org/



Relevant Research Papers

Diagnosis and Treatment of Vitamin D Deficiency
JJ Cannell , BW Hollis, M Zasloff & RP Heaney
Atascadero State Hospital, 10333 El Camino Real, Atascadero, California 93422, USA
http://www.vitamind-cannell.ms-diet.org


References

Ascherio A, Munger KL., 2007, Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors. Ann Neurol. 61(6):504-13.

Giovannoni G, Ebers G., 2007, Multiple sclerosis: the environment and causation.
Curr Opin Neurol; 20(3):261-8.

Hathcock JN, Shao A, Vieth R, Heaney R., 2007, Risk assessment for vitamin D.
Am J Clin Nutr 85(1):6-18.

Holmøy T., 2008, Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis.
Med Hypotheses.70(1):66-

Islam T, Gauderman WJ, Cozen W, Mack TM., 2007, Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology. 69(4):381-8.

Kampman MT, Wilsgaard T, Mellgren SI., 2007, Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol. 254(4):471-7.

Kimball SM, Ursell MR, O'Connor P, Vieth R., 2007, Safety of vitamin D3 in adults with multiple sclerosis. Am J Clin Nutr. 86(3):645-51.

Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP., 2007, Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 85(6):1586-91.

Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A., 2006, Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA.296(23):2832-8.

Soilu-Hanninen M, Laaksonen M, Laitinen I, Eralinna JP, Lilius EM, Mononen I., 2007, A longitudinal study of serum 25-hydroxyvitamin D and intact PTH levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis.
J Neurol Neurosurg Psychiatry.

Van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Taylor BV, Kilpatrick T, Butzkueven H, McMichael AJ., 2007, Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. J Neurol. 254(5):581-90

Vieth R., 1999, Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 69(5):842-56.

Vukusic S, Van Bockstael V, Gosselin S, Confavreux C., 2007, Regional variations in the prevalence of multiple sclerosis in French farmers. J Neurol Neurosurg Psychiatry. 78(7):707-9.

Woolmore JA, Stone M, Pye EM, Partridge JM, Boggild M, Young C, Jones PW, Fryer AA, Hawkins CP, Strange RC., 2007, Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation. Mult Scler.13(3):369-75.





Vitamin D Supplementation in the Fight Against MS.

Practical Information Sheet – Issue 1(Jan 2008)

Introduction: The most reliable indicator of circulating vitamin D levels is the 25(OH)D test and regular testing of this, both before and during supplementation, is essential.

The key is to ensure a level of circulating vitamin D - 25(OH)D - of between 125 and 150nmol/l which is considered to be the optimum range to maintain good health and to reduce the risk of autoimmune reactions developing into full-blown autoimmune disease.
The advised procedure is this.
1. Arrange for a 25(OH)D blood test at your doctors before beginning supplementation. You will need to obtain your GP's continued support for this and, in the circumstances, it would seem advisable to show him/her the attached letter(Jan 2008), with the very latest research linking MS with vitamin D deficiency. Indeed, it would make sense to send this to the surgery, marked for the attention of your GP, a few days in advance of your appointment to allow time to peruse both the online presentations and the latest paper by Cannell et al.
2. In the UK, this test should be available free of charge from your GP although some group members have had to pay a nominal fee in the past so don't be surprised if this is the case.
3. Make sure they order the correct test. It is the 25(OH)D test, NOT the 1,25(OH)D test.
4. Be warned, it can take several weeks to obtain the results and, as mentioned previously, you should also have your serum calcium levels checked at the same time and these should remain in the range 2.2-2.6 nmols/L, at all times, to ensure hypercalcemia does not develop.
5. When the results are back, make sure they give you the actual figures. You will need this to compare with future readings. The aim is to raise your levels to the range 125-150 nmols/L as quickly as possible and, as a starting point, the current advice is to use a daily supplement of 2000iu in summer and 4000iu in winter.
6. Different labs can use different units and while many will give the results in nmols/L, just as many will quote ng/ml(nanogramms per millilitre) but there is a simple conversion factor between the two. When the figures are given in the latter units, just multiply by 2.5 to convert to nmols/L. (Please note that ug/l and pg/ul are the same as ng/ml and, as such, the same conversion factor applies.)
7. We would ask that you remember to record your 25(OH)D and serum calcium test results on our website, as part of our online BBD Questionnaire(s). [Available March 2008] If you do not have internet access, just call (0)800 783 0518 and the MSRC staff will do this on your behalf.
8. It is essential(to prevent osteoporosis), that while supplementing with vitamin D3(cholecalciferol), you have an adequate intake of calcium/magnesium. If you are avoiding dairy(Best Bet Diet) you must also supplement with 1200mg essential calcium and 600-1200mg magnesium.
9. If you have children and intend to use vitamin D as a protection against them developing the condition, it is important to discuss this with your doctor as well and have their levels of 25(OH)D and serum calcium checked BEFORE starting the process.
10. Once again, we would ask that you let us know their figures for our study.
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Re: Vitamin D supplementation in the fight against MS

Postby NHE » Tue Jul 08, 2008 2:39 am

Hi Nick,
Thanks for sharing this article.
He interpreted that adequate vitamin D in childhood prevents MS by regulating the immune system such that it does not produce myelin-sensitive immune cells during and after infections with childhood viruses such as Epstein-Barr.

This quote makes me wonder what vitamin D may or may not do for other autoimmune diseases?

NHE
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Re: Vitamin D supplementation in the fight against MS

Postby Nick » Tue Jul 08, 2008 7:30 am

NHE wrote:Hi Nick,
Thanks for sharing this article.
He interpreted that adequate vitamin D in childhood prevents MS by regulating the immune system such that it does not produce myelin-sensitive immune cells during and after infections with childhood viruses such as Epstein-Barr.

This quote makes me wonder what vitamin D may or may not do for other autoimmune diseases?

NHE


N

I believe vitamin D is the common denominator to most if not all of the AI disorders. For instance Hypponen et al demonstrated that infants given 2,000 IU/d via CLO for the first year of life had a risk reduction of 80 % for type 1 diabetes.

Cheers
N
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Postby cheerleader » Tue Jul 08, 2008 11:50 am

Thanks for all the info, Nick.
I really appreciate your posts.
I began giving my 13 yr. old son vitamin D supplements when my husband was dx last year. This, and lots of so cal sunshine, should help protect his immune system.
My husband grew up in California, and spent alot of time outside in the sun. (He has the basal cells to prove it.) His serum vit. D levels are normal with supplementation. I continue to wonder if there is something interfering with vit D production and absorption in MSers. Perhaps a melanin disorder, cholesterol or liver problem? Could vit. D depletion be part of the autoimmune disease process?
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Nick » Wed Jul 09, 2008 8:17 am

cheerleader wrote:Thanks for all the info, Nick.
I really appreciate your posts.
I began giving my 13 yr. old son vitamin D supplements when my husband was dx last year. This, and lots of so cal sunshine, should help protect his immune system.
My husband grew up in California, and spent alot of time outside in the sun. (He has the basal cells to prove it.) His serum vit. D levels are normal with supplementation. I continue to wonder if there is something interfering with vit D production and absorption in MSers. Perhaps a melanin disorder, cholesterol or liver problem? Could vit. D depletion be part of the autoimmune disease process?
AC


Hi AC

I'm glad someone does ;-)

You mention your man's levels are normal. Normal by what standards? A GP's or an evolutionary or immunoregulatory standard? The only way to pass judgement is to know what his actual measured serum concentration is. Which doesn't necessarily speak for his historical levels.

I agree that as a longtime resident of California he probably had ample opportunity for sun exposure and you say he did spend a lot of time outside so he is an unlikely candidate to develop MS (or any other AI disease for that matter). Yet there could still have been opportunites in his past to have had sub optimal levels of vitamin D.

His history of sun exposure probably endowed him with advantages though, such as a later age of MS diagnosis implying a immunosuppressive advantage, the status of his disease progression and degree of disabilty etc. Can you comment on this factors please?

To my knowledge a malfunction of his ability to produce vitamin D is possible though not probable. The higher his cholesterol the better for producing vitamin D so he would have to have very low cholesterol for it to be an issue. Again possible though not probable. Ditto with the liver although vitamin D is also produced elsewhere throughout the body. I guess your guy is just... lucky, as in bad luck.

Cheers
Nick
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Postby cheerleader » Wed Jul 09, 2008 3:41 pm

Hi Nick-

Jeff was diagnosed last year. He has 20 lesions in his brain (mostly corpus callosum) and one on his cervical spine. He has not progressed since his first attack, however he has terrible residual fatigue, muscle spasms and leg pain since that attack. I believe he has had MS most of his adult life, which first manifested as depression in his late twenties. He is now 45 years old.

I began his vitamin D supplementation and many other supplements the first week after his diagnosis. Here's his story, and the program I put together for him:
http://www.thisisms.com/ftopict-4975.html

He lived in Rochester, NY and New York City six years during his late teens and early twenties- when we were in college and starting our careers, and I'm sure his vitamin D levels were low then. Lots of snow, not much sun. His GP says his serum levels of vit. D are high normal now, but I don't have the numbers in front of me.

Thanks for all you're doing to help the cause. I read many of your posts while putting together Jeff's program.
all the best,
the Aging Cheerleader
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Nick » Thu Jul 10, 2008 11:17 am

AC

Wow, I can see who wears the pants in your household .... and who tells him when to take them off and put them on. Bravo for your proactive actions.

There are two points I'd like to comment on.

You write that Jeff has residual fatigue and don't state his dietary regime includes a prohibition of gluten. Is it accurate to say he still consumes gluten containg products, even if it is non-white flour?

Ron Hoggan believes partly digested proteins, called peptides, can pass through the intestinal wall, and into the circulation. In gliadin (i.e. gluten) there are five distinct peptides, all of which have been shown to be both psychoactive and to bind to opioid receptors in the brain. He believes this accounts for the overrepresentation of pshychiatric disorders (e.g. depression, schizophrenia) in celiacs and could account for such phenomena in MS as brain fog and fatigue.

Anecdotally, one of the first improvements I noticed after embracing diet revision was the markedly reduced/elimination of my consistently overwhelming fatigue.

Cheers
Nick
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Postby cheerleader » Thu Jul 10, 2008 12:13 pm

Ha! No pants, here. I wear the apron. Since I'm chief cook and bottle washer in the family, Jeff lets me dictate nutrition. He trusts me to help him navigate this disease, as he truly does not have the time to. He's currently working on three TV shows and one film. He's taking control of his MS, by following the program I've spent hours and hours researching. We're a good team.

Jeff's been off gluten for years, first for weight maintenance, now for his MS diet. He also has been off simple carbohydrates...no pasta, bread, potatoes, sweets for at least ten years. He likes staying slender. Ah, vanity! I sometimes make side dishes of brown rice or pasta for myself and son, but Jeff does not indulge. His only carbs are veggies and some fruits. He even gave up wine :(

I'm glad the gluten free diet helped your fatigue...you're absolutely right about the peptides.

I attribute Jeff's fatigue to the location of his lesions...the corpus callosum connects the left and right hemispheres of his brain, and is in constant use as he composes music. His neuro couldn't believe his lack of disability after studying his MRI. He's rerouted his brain...would be a good case study for Oliver Sacks! Also, he does not sleep soundly, since his spasms continually kick him out of deep sleep. He's never truly rested, poor man.

Thanks for the personal input...nothing like having the internet to bounce around ideas across the continents. I truly believe the vit. D , diet, and supplements will allow Jeff many more years of healthy, productive living...and will benefit many others.
best,
the pantless cheerleader
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Vit D

Postby bromley » Mon Jul 14, 2008 6:02 am

Firstly, I received a number of complaints about the volume of postings by Lyon (Bob to his friends - I'm assuming he has more than one). He's now passed 3,000 posts - which is a travesty. Worse still - he's starting to appear on other MS websites - he's like a sexually transmitted disease. I'm going to have a word with Arron about charging Bob a $ a posting - proceeds go to MS research. That's fair isn't it?

More improtantly, I posted this under the recent EBV thread, but thought it worth posting separately. As usual, Vit D is good for MS with mice - which is strange because I thought mice were nocturnal creatures - don't see many sunbathing on a beach.

Vitamin D, hope for a new disease fighter for Multiple Sclerosis 14 July 2008

In a Newark laboratory, researchers watch as mice stricken with multiple sclerosis suddenly walk. They peer into microscopes and see the growth of breast cancer cells dramatically slowed.

They are examining, up close, the power of vitamin D.

"We're believers," said Sylvia Christakos, a longtime vitamin researcher at UMDNJ-New Jersey Medical School.

Many others are following. A spate of provocative studies shows the potential health benefits of vitamin D on everything from breast, prostate and colon cancer to auto- immune disorders such as Type I diabetes, rheumatoid arthritis, lupus and multiple sclerosis.

The so-called "sunshine vitamin" may even protect the heart.

Some researchers, citing widespread vitamin D deficiencies among Americans, call current federal guidelines outdated and argue most people need far more of the nutrient than they get from food, multi-vitamins and the sun.

Others say more research is needed before Americans start downing supplements or exposing unprotected skin to height-of-the- day sun, whose ultraviolet rays help create the vitamin.

Few researchers, however, have studied the nutrient more closely than Christakos.

"There is finally more of a recognition of the value of vitamin D to prevent various diseases," she said. "But it's cheap and over-the-counter so you won't turn on the television and see commercials pushing vitamin D."

In a review scheduled for publi cation this week in the online Journal of Cellular Biochemistry, Christakos and her team conclude proper blood levels of vitamin D can protect people from multiple sclerosis. The review said the nutrient may help maintain balance in the immune system.

The team looked at MS in mice, and found those treated early with an active form of vitamin D improved dramatically. The stricken mice, once paralyzed, were able to walk, though Christakos said that does not mean the same will happen for people with MS.

The lab has gone a step further to show how vitamin D may work on a genetic level. Working with researchers from Stanford University, they showed how vitamin D likely inhibits a key inflammatory response involved in MS.

The data on vitamin D is accumulating. For example:


A Canadian study found women with breast cancer were nearly twice as likely to see their cancer spread, and far more likely to die, if deficient in the vitamin.


A 2007 study in the American Journal of Clinical Nutrition concluded improving calcium and vita min D levels substantially reduces all cancer risk in post-menopausal women.


In last year's New England Journal of Medicine, researcher Michael F. Holick of Boston University School of Medicine cited a study that found elderly French women given 1,200 mg of calcium and 800 international units (IU) of vitamin D daily for three years reduced their risk of hip fracture by 43 percent.

Holick cited another study that found women who took more than 400 IU of vitamin D had a 42 percent reduced risk of developing multiple sclerosis. Another study found that 10,366 Finnish children who were given 2,000 IU of vitamin D per day during their first year of life and were followed for 31 years had their risk of developing Type I diabetes reduced by 80 percent.

Holick said Americans should take at least 1,000 IU of vitamin D daily as well as a multivitamin with another 400 IU. Christakos said vi tamin D supplements are especially important for those at risk of immune disorders, such as siblings of people with Type I diabetes or MS.

Government guidelines, however, recommend just 200 IU for those under 50; 400 for those 51-70; and 600 for those over 70.

Jennifer Koentop, a spokeswoman for the U.S. Department of Health and Human Services, said the government is negotiating with the Institute of Medicine, a national advisory organization, to review the vitamin D guidelines.

Humans once routinely absorbed vitamin D from the sun, but when jobs and society moved in doors exposure to sunlight dropped. Holick estimates half of all Americans are vitamin D deficient. Deficiency rates among African-Americans may be higher.

Reinhold Veith, a researcher at the University of Toronto, said people can safely put on a bathing suit and expose much of their skin, without sunscreen, for as little as five minutes several times a week to obtain vitamin D.

Most dermatologists disagree, however. The American Academy of Dermatology, on its website, said people who want additional vita min D should use supplements to prevent skin cancer and damage.

Debate continues over supplements, too. Laura Byham-Gray, associate professor of nutritional sciences at the UMDNJ-School of Health Related Professions, does not recommend higher doses.

"What we consider a vitamin D deficiency is still under debate," she said. She cites the hype that once surrounded vitamin E, which researchers later learned actually increased mortality.

Vitamin D proponents said as much as 10,000 IU daily will not cause toxicity.

"Policy makers want a high level of evidence before committing themselves," Veith said. "But all the accumulating evidence on vitamin D has been like a slow rising sun. When do you call it daytime?"

Source: nj.com © 2008 The Star-Ledger 14/07/08
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Postby jimmylegs » Mon Jul 14, 2008 7:13 am

they should have specified why african americans might be at more risk of deficiency, because it applies to indoor, and/or covered, and/or darkly pigmented, and/or aged populations. if you are all of the above, you may want to start chowin down on some whale. or fish oil if you're picky.
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Postby Lyon » Mon Jul 14, 2008 12:34 pm

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Last edited by Lyon on Mon Nov 28, 2011 2:11 pm, edited 1 time in total.
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