all things vitamin D

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Postby cheerleader » Mon Apr 13, 2009 5:06 pm

peekaboo wrote:Ru -

The fact that MS is rare around the exuator is connected with the sunshine only, isn´t it?


not just sunshine but civilization environmental toxins industry etc.


I think there's also a genetic component. Oz was settled by brits- who have higher MS rates. Mostly native populations live along the equator (think Central America, Africa) The aboriginal people in Australia don't have MS, it's the white folk who came from Europe. Same in South Africa.

That said- toxins, viruses, antibiotics, metals, stress, saturated fats, high glucose, pesticides and all the modern civ. baddies promote autoimmune disease, inflammation and endothelial dysfunction. Genetic predisposition combined with environmental triggers....bang.
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby RuSmolikova » Mon Apr 13, 2009 9:44 pm

cheerleader wrote:I think there's also a genetic component. Oz was settled by brits- who have higher MS rates.

Good point! Thanks.
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Postby jimmylegs » Tue Apr 14, 2009 5:01 am

yes there are definitely far lower ms rates among the aboriginal and torres strait islanders than non-aboriginal australians - although if you hunt for it, there are hints that it's starting to make an appearance (in spite of relative access to health care discrepancies etc).
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Postby RuSmolikova » Tue Apr 14, 2009 5:10 am

Another Q: Why there is so many MS patients among inhabitants of Sardinia island? They are of the same race as other Italians, the same sunlight, similar fish oil input, environment, etc...
But MS rate is much higher in Sardinia... :roll:
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Postby jimmylegs » Tue Apr 14, 2009 5:58 am

i'd be inclined to say they were looking for it harder there, so they found it more.

however according to this study, that only accounts for part of the discrepancy:

The marked increase of MS incidence and the change of MS clinical phenotype over time cannot be explained by ascertainment bias only,


so something changed in the environment:

thus pointing to a corresponding change in the distribution of exogenous risk factors in this highly genetically stable population.

from result #5 in regular google search on:
sardinia incidence ms

pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/15990443

some have linked the changes in ms risk in sardinia to disappearance of malaria. i'd be taking a good hard look at history of ddt/similar use.
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Postby cheerleader » Tue Apr 14, 2009 6:30 am

I've mentioned this somewhere before...can't find it.
Sardinia is/was a huge industrial mining location- and their drinking water has been found to be polluted with heavy metals-
Geochemical studies in these areas have identified the main sources of contamination to be from drainage of flooded mines, mining wastes and tailings abandoned in settling ponds, and exposed ores. The transport of the fine materials eroded from the tailings ponds contributes to spreading pollution over larger areas downstream. Concentrations of Pb, Cd and Zn in the streams draining the mining area (up to 1, 1.7, and 1000 mg l–1, respectively) are several orders of magnitude higher than those observed in rivers outside the mining areas in Sardinia

http://geea.geoscienceworld.org/cgi/con ... ct/2/3/243

There's actually an Italian study( in Italian- no link) from the '50s which linked diseases to mining pollution-
[Diseases caused by dynamite explosions in Sardinian mining industry.]

Metals (especially cadmium) destroy the endothelial balance of nitric oxide (studies cited in my paper) and can be part of the tipping point for MS-
AC
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby SarahLonglands » Tue Apr 14, 2009 7:31 am

All this is true, but miners spend most of the daylight hours in darkness.

Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby Lyon » Tue Apr 14, 2009 8:37 am

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Postby notasperfectasyou » Tue Apr 14, 2009 9:33 am

Am I too late?

Kim's taking a boat load of D3. So while we are shaking this out, doesn't D3 trigger Ceramide? Can anyone explain Ceramide and whether there is a possible issue with D3 becasue of it? Ken
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Postby patientx » Tue Apr 14, 2009 10:14 am

RuSmolikova wrote:Another Q: Why there is so many MS patients among inhabitants of Sardinia island? They are of the same race as other Italians, the same sunlight, similar fish oil input, environment, etc...
But MS rate is much higher in Sardinia... :roll:


If the occurrence of MS did coincide with the elimination of malaria, then maybe JL is on to something, that it's related to DDT use. Of course, if new cases of MS are being reported, then either the DDT would have had to cause a genetic change in the previous generation, or the DDT is still in the environment.
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Postby Lyon » Tue Apr 14, 2009 10:46 am

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Postby RuSmolikova » Tue Apr 14, 2009 1:06 pm

Thanks for all the points, friends! :wink:

But I´ĺl mention very very very simple one: How about phenomenon of "lost enemy"?

If the immune system is set up to a certain level (dealing with malaria) and then the enemy is taken off. The immune system starts to seek another enemy and find it in CNS...
No matter if the DDT has been used and so on...

That could explain the fact that MS is rare around the equator (malaria and others). Immune system of people there hasn´t lost its enemy...
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Postby Lyon » Tue Apr 14, 2009 1:35 pm

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Postby RuSmolikova » Tue Apr 14, 2009 3:28 pm

Lyon wrote:...I'm not sure what science it would be based on.


A friend of mine always says: "When they find out the cause of MS, we all will gape at the horseshit it will be! All people see it but don´t take it into account."

Did biologist Alexander Fleming expect to discover penicillin leaving his petri dishes, in 1928? :wink:
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Postby Lyon » Tue Apr 14, 2009 4:04 pm

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