Further research is required to explore potential genetic links between low vitamin D levels and pigmentation. Polymorphisms in the vitamin D binding protein and vitamin D hydroxylase ( CYP2R1) genes influence vitamin D levels although vitamin D receptor (VDR) genotypes have not been consistently linked to vitamin D levels in healthy individuals . In prostate cancer patients, the Fok1 ff VDR polymorphism when associated with low plasma vitamin D levels conferred the highest risk of prostate cancer in the USA as well as giving rise to more aggressive tumours . The anti-proliferative and differentiation effects of vitamin D on many cell types have long been known with therapeutic targets such as psoriasis and cancer but the effects of vitamin D are very complex with the involvement of many pathways in the cell cycle . It is becoming apparent that skin pigmentation via the MSH pathway is involved in cell survival and proliferation as well as inflammation so it is possible that pigmentation genes and genes involved in vitamin D metabolism may be linked .
new study on vitamin D in fair skinned women in UK...could low serum D levels be linked to your genetics-regardless of D intake?
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