all things vitamin D

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Postby turtle_fi » Fri Aug 21, 2009 7:03 am

hmm. maybe this would be worth testing for me too. i have always had dry skin, and especially in young age it was bad. i still easily have skin infections that go on forever (months at least)

diet low-carb which is high in fat helps my skin to be "greased from inside".
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Postby jimmylegs » Fri Aug 21, 2009 8:02 am

ww i'm going to relay that info about d3 helping your migraines, to a friend.

i went looking for other things that happen in the skin besides making d3, when exposed to sunlight. because my d3 status is great but my skin still sucks. so yesterday i learned about fumaric acid. i wonder what the heck else the skin makes when exposed to UV???

anyway, so now i'm sort of wrapped up in fumaric acid, and serum levels of that other metabolite of d3 1,25 dihydroxycholecalciferol, and phosphate and child levels vs adult, renal function, etc etc...
i will let you know if i figure out how to cure my skin too lol

in the meantime, still keeping tabs on the d3. was at the lab yesterday, gave some blood to see if i'm back down in the 100-250 range again, after a month and a half off from d3 supplements (still eating fish though).

ttfn,
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Postby ElMarino » Sat Aug 22, 2009 4:42 am

Thanks JL - I'll read the regimens D3 thread when I have lots of free time, although I did skim through it.

Good luck with the fumaric acid..
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Postby patientx » Sat Aug 22, 2009 3:38 pm

jimmylegs wrote:i went looking for other things that happen in the skin besides making d3, when exposed to sunlight. because my d3 status is great but my skin still sucks. so yesterday i learned about fumaric acid. i wonder what the heck else the skin makes when exposed to UV???

anyway, so now i'm sort of wrapped up in fumaric acid, and serum levels of that other metabolite of d3 1,25 dihydroxycholecalciferol, and phosphate and child levels vs adult, renal function, etc etc...
i will let you know if i figure out how to cure my skin too lol
JL


JL,

This is interesting you mention fumaric acid. One of the drugs in phase III trials right now, BG12, is dimethyl fumarate, an oral fumarate derivative. And another interesting thing, since you mention your skin, is that it was originally developed (or at least used) as a treatment for psoriasis.
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Postby jimmylegs » Sun Aug 23, 2009 6:22 pm

indeeeed lol! the oral form also caused some major kidney problems in a couple of psoriasis sufferers. jury's still out, i guess :( i haven't read enough to understand it yet. i just got a slight handle on the urea cycle and now i have to figure out the citric acid cycle??
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Why Low Vitamin D Raises Heart Disease Risks In Diabetics

Postby Frank » Tue Aug 25, 2009 12:13 am

Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.
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Vitamin D and the higher incidence of AI diseases in Women

Postby ElMarino » Tue Sep 08, 2009 1:33 pm

http://www.examiner.com/x-16026-Napa-Co ... s-in-women




Vitamin D and the higher incidence of autoimmune diseases in women

It has long been observed that autoimmune diseases like lupus and multiple sclerosis are more common in women than in men. Other related chronic conditions such as osteoporosis, osteoarthritis and chronic fatigue syndrome are also much more common in women as well. Two research papers published in the upcoming September, 2009 special issue of the Annals of the New York Academy of Sciences, titled Contemporary Challenges in Autoimmunity, show a possible connection that involves vitamin D and how it is metabolized in the body.

Vitamin D (also called cholecalciferol) is important in both men and women, and at first glance it would seem that it should behave the same way in both sexes. It has no role in sex-specific hormonal regulation like some of the sex hormones, but it has recently been discovered that a special molecule, called a receptor, that binds to one of the forms of vitamin D is more abundant in women than men. The receptor to which vitamin D binds is important in the activation of the innate immune response.

The vitamin D receptor (VDR) is found in the nucleus of certain cells throughout the body. Recently it was discovered that women have more of these receptors, because in addition to all the same kinds of cells shared with men, they also have VDRs in endometrial cells. Endometrial cells, which comprise the lining of the uterus, are cyclical. Therefore, the number of VDRs fluctuates in sync with the menstrual cycle.

The key

1,25-D, also called calcitriol. This is the form of vitamin D that binds to vitamin D receptors (VDRs). Source: Wikipedia.
to how vitamin D plays its part is to understand what the VDR does. When the correct form of vitamin D (a form known as 1,25-D or calcitriol) binds to VDR, VDR then directly causes the expression of over 900 genes to occur. Two of the genes that are turned on produce proteins that are directly responsible for kicking the immune response into active mode. The reason for VDR in the endometrium is that it provides protection against infection for the developing fetus.

Another key to the puzzle has been the growing evidence that bacteria may play a role in the development of autoimmune disease. If so, why wouldn’t women, who have more VDRs, be better off than men? The problem is that bacteria of various kinds can interfere with VDRs and prevent vitamin D from binding. If vitamin is unable to bind, then the immune response is disrupted. Not only is the immune system affected, but thyroid hormone problems can result too.

Although these results do not provide a clear path to treatment, “the potential role of persistent pathogens in autoimmune disease mandates reconsideration of the use of corticosteroids as a first-line treatment for many autoimmune diseases. Corticosteroids effectively reduce the ability of the immune system to respond to pathogens, including persistent microbiota, which is counterproductive to recovery.”

As a result of the dysregulation of VDRs blood levels of the 1,25-D form of vitamin D increase, because less 1,25-D is binding. “Given the potential benefits of serum 1,25-D as a clinical marker both in the diagnosis and monitoring of treatment response, further research is warranted. If elevated levels of 1,25-D continue to be associated with an inflammatory disease state, 1,25-D could be used as a reliable marker of the autoimmune disease process.”

Sources:

Amy D. Proal, Paul J. Albert, and Trevor G. Marshall. 2009. Dysregulation of the Vitamin D Nuclear Receptor May Contribute to the Higher Prevalence of Some Autoimmune Diseases in Women, In Contemporary Challenges in Autoimmunity. Annals of the New York Academy of Sciences 1173: 252–259.

Greg P. Blaney, Paul J. Albert, and Amy D. Proal. 2009. Vitamin D Metabolites as Clinical Markers in Autoimmune and Chronic Disease, In Contemporary Challenges in Autoimmunity. Annals of the New York Academy of Sciences 1173: 384–390
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Vitamin D Pill question

Postby patientx » Wed Sep 16, 2009 7:45 am

I stopped at GNC the other night to pick up some more Vitamin D pills. They had a brand that are 5000 IU's in a gelcap. Does anyone know if these are for real? They are tiny compared to 1000 IU horse pills I bought last time.
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Postby jimmylegs » Wed Sep 16, 2009 9:52 am

i'm betting on for real. i don't know why a 1000 iu d3 pill would be a horse pill. i've seen pretty tiny 50,000IU pills before. (d2 though not d3)
my d3 liquid provides 25,000iu in a single drop.
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Postby ElMarino » Wed Sep 16, 2009 6:45 pm

Superior Source manufacture tiny 10,000 iU D3 pills..

http://www.evitamins.com/product.asp?pid=13487

2,500% of the recommended daily..

I don't know if they will stop relapses but I hope so. My eczema has cleared up since starting taking them which may, or may not, be coincidence..
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Vit D stauts correlates with reg T-cells

Postby Frank » Thu Nov 12, 2009 3:24 am

Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis.

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands. j.smolders@mumc.nl

BACKGROUND:
In several autoimmune diseases, including multiple sclerosis (MS), a compromised regulatory T cell (Treg) function is believed to be critically involved in the disease process. In vitro, the biologically active metabolite of vitamin D has been shown to promote Treg development. A poor vitamin D status has been linked with MS incidence and MS disease activity. In the present study, we assess a potential in vivo correlation between vitamin D status and Treg function in relapsing remitting MS (RRMS) patients.

METHODOLOGY/PRINCIPAL FINDINGS:
Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured in 29 RRMS patients. The number of circulating Tregs was assessed by flow-cytometry, and their functionality was tested in vitro in a CFSE-based proliferation suppression assay. Additionally, the intracellular cytokine profile of T helper cells was determined directly ex-vivo by flow-cytometry. Serum levels of 25(OH)D correlated positively with the ability of Tregs to suppress T cell proliferation (R = 0.590, P = 0.002). No correlation between 25(OH)D levels and the number of Tregs was found. The IFN-gamma/IL-4 ratio (Th1/Th2-balance) was more directed towards IL-4 in patients with favourable 25(OH)D levels (R = -0.435, P = 0.023).

CONCLUSIONS/SIGNIFICANCE:
These results show an association of high 25(OH)D levels with an improved Treg function, and with skewing of the Th1/Th2 balance towards Th2. These findings suggest that vitamin D is an important promoter of T cell regulation in vivo in MS patients. It is tempting to speculate that our results may not only hold for MS, but also for other autoimmune diseases. Future intervention studies will show whether modulation of vitamin D status results in modulation of the T cell response and subsequent amelioration of disease activity.

PMID: 19675671 [PubMed - in process]

--Frank
Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.
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Vitamin D and Rebif

Postby patientx » Wed Nov 18, 2009 5:29 pm

I posted this in the Rebif forum, but thought it might be of general interest:

http://tinyurl.com/yamayxx

The investigators hypothesize that vitamin D supplementation may ameliorate interferon beta-induced flu-like symptoms, owing to reduced release and activity of the cytokines that are in correlation with this adverse event.


I wonder if their hypothesis is based on something concrete.
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Postby Sawdoggie » Wed Nov 18, 2009 8:21 pm

Since they didn't mention specifically beta-1a or beta-1b I am guessing this includes Betaseron in addition to Avonex and Rebif. I started Betaseron last May along with Vitamin D (4,000 iu/day) after being diagnosed and never experienced any of the side effects or site reactions that I read so much about. Maybe I was just one of the lucky ones or maybe the D helped... This will be interesting to see how it plays out.
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Postby patientx » Thu Nov 19, 2009 4:39 am

Good point, Sawdoggie. I saw Interferon Beta and automatically thought of Rebif. But, like you said, it probably could also apply to Betaseron.

Based on your experience, maybe there is something to this.
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Question About Vitamin D and Iron Overload/CCSVI

Postby harry1 » Mon Nov 23, 2009 2:39 pm

Hi everyone

I was just wondering if anybody has done any research to see if low levels of vitamin D are associated with abnormal levels of iron buildup that's causing CCSVI? It sure seems that low levels of vitamin D/sunshine are associated with MS in my readings over the years and so with all the news coming out about iron overload causing CCSVI i was thinking they could be interconnected possibly?

Thanks !!
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