msmything wrote:In the meantime, may I ask how your Vit D levels were adjusted, I thought I read that it is an initial injection, followed by monster pills 1x week?
And how is Calcium def. treated?
jimmylegs wrote:and never let them brush you off with the 'normal' thing!
huge decades long body of literature on this, and 4000IU per day is considered MAINTENANCE not a therapeutic boost.
[article link here]
Total-body sun exposure easily provides the equivalent of 250 µg (10,000 IU) vitamin D/d, suggesting that this is a physiologic limit.
To ensure that serum 25(OH)D concentrations exceed 100 nmol/L, a total vitamin D supply of 100 µg (4,000 IU)/d is required.
Published cases of vitamin D toxicity with hypercalcemia, for which the 25(OH)D concentration and vitamin D dose are known, all involve intake of 1000 µg (40,000 IU)/d. ...the weight of evidence shows that the currently accepted, no observed adverse effect limit of 50 µg [b](2000 IU)/d is too low by at least 5-fold.
in '06 i used this second study to calculate how long it would take me to get to 100nmol/l taking 5000IU per day and it came out to something like 8 months which was when I first started investigating short term megadosing for a therapeutic boost, and then a few thousand a day maintenance.[article link here]
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
...Design: Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25 (1,000 IU), 125 (5,000IU), and 250 µg (10,000 IU) cholecalciferol for 20 wk during the winter to 67 men living in Omaha (41.2° N latitude)...
Results: From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of 0.70 nmol/L for each additional 1 µg cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 µg (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting (autumn) 25-hydroxycholecalciferol concentration was estimated at 96 µg (3800 IU)/d. By difference, the tissue stores provided 78–82 µg/d.
Conclusions: Healthy men seem to use 3000–5000 IU cholecalciferol/d, apparently meeting > 80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
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