Mirry wrote:He also strongly advocates getting plenty of sun, as the body of a white person can produce 25,000 untis simple by spending a half hour in the sun.
At my appointment yesterday I asked my specialist if there was anything I should avoid with MS. He pointed out of the window to the "sun" and told me to stay out of it as it is not good for people with MS I did tell him it's a little difficult living in Las Vegas.
Has anyone else heard this, as so far, most things I read, say a little sun is good for those with MS
...Total-body sun exposure easily provides the equivalent of 250 microg (10,000 IU) vitamin D/d, suggesting that this is a physiologic limit.
...The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10,000 IU) vitamin D/d.
...To ensure that serum 25(OH)D concentrations exceed 100 nmol/L, a total vitamin D supply of 100 microg (4000 IU)/d is required.
Except in those with conditions causing hypersensitivity, there is no evidence of adverse effects with serum 25(OH)D concentrations <140 nmol/L, which require a total vitamin D supply of 250 microg (10000 IU)/d to attain.
Published cases of vitamin D toxicity with hypercalcemia, for which the 25(OH)D concentration and vitamin D dose are known, all involve intake of > or = 1000 microg (40,000 IU)/d.
Because vitamin D is potentially toxic, intake of >25 microg (1000 IU)/d has been avoided even though the weight of evidence shows that the currently accepted, no observed adverse effect limit of 50 microg (2000 IU)/d is too low by at least 5-fold.
When atmospheric conditions are ideal and skies are clear, 30 minutes of whole-body exposure of pale skin to sunlight without clothing or sunscreen can result in the synthesis of between 10,000 and 20,000 IU of vitamin D. These quantities of vitamin D are large, and therefore capable of supplying the body's full needs.
Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D.
Zn2+ can inhibit PRL secretion within a range of physiologically and pharmacologically relevant concentrations
This study correlates plasma levels of Zinc (Zn) and some pituitary and testicular hormones in 20 uremic men (aged 17–58 years) on a weekly peritoneal dialysis program. Patients were compared to 12 healthy male volunteers (aged 28–40 years). In uremic men, plasma andros-tenedione (A) was elevated, while testosterone (T), dihydrotestosterone (DHT), and Zn were low. On a group basis, plasma follicle stimulating hormone (FSH) and luteinizing hormone (LH) were normal while prolactin was increased.
Zinc and prolactin levels were measured in 32 male haemodialysis patients; 12 were receiving 50 mg zinc per day as zinc acetate and 20 were not. Zinc-treated patients had significantly higher plasma zinc levels (134±10 μg/dl v 88±2 μg/dl) and lower serum prolactin levels (11±4 ng/ml v 29±7 ng/ml) than untreated patients. Plasma zinc and serum prolactin were inversely related in zinc-treated and untreated patients (r = -0·79, p<0·001).
The serum copper concentration was elevated, serum zinc concentration and zinc/copper ratio were decreased in the hypercholesterolemic group (cholesterol greater than 7.7 mmol/l).
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