all things vitamin D

Discuss herbal therapies, vitamins and minerals, bee stings, etc. here

Postby 1hunter » Fri Feb 18, 2011 9:40 am

are there suppliments we should NOT take at the same time that dont mix well?
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Postby jimmylegs » Fri Feb 18, 2011 3:46 pm

not take at the same time as d3, do you mean? well i know if you take magnesium that you definitely must take some of your daily dose *with* the d3, and the rest of it at a separate time. d3 makes use of magnesium as it gets processed. but your body needs mag for other things not just d3 handling. i learned this the hard way and it was a pharmacist that got me back on track.
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Postby 1hunter » Fri Feb 18, 2011 4:26 pm

Thanks Jimmy
that is good to know, are there others that should or shouldn't be mixed? I thought i read we should take fish oil with vit. D But not calcium with with fish oil.
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Postby CVfactor » Fri Feb 18, 2011 5:47 pm

The review article below is probably the best that I have found that explains the regulatory T-cell function in a easy to understand way:

http://www.nature.com/nrneurol/journal/v4/n7/full/ncpneuro0832.html
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Postby jimmylegs » Fri Feb 18, 2011 7:33 pm

hey there no probs. i had not heard pros or cons about fish oil timing/combinations, but i do know that magnesium and calcium compete with each other for absorption so that's a combo to avoid in the same pill OR make sure the ratio of ca to mag is right for you, depending on your problem eg spasticity vs weakness or whatever.
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Postby CVfactor » Wed Feb 23, 2011 5:52 pm

Here is another article on Treg cell dysfunction using monkeys as opposed to mice as test subjects:

http://www.ncbi.nlm.nih.gov/pubmed/19539557
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Postby CVfactor » Sun Feb 27, 2011 5:46 pm

Here is a paper that describes the concept of molecular mimicry:

http://www.ncbi.nlm.nih.gov/pubmed/19303388

For those that are not familiar, it is in essence the fact that certain pathogen peptides have a remarkably similar structure to that of myelin basic protein.

This is one explanation of why people with MS that have a dysfunctional immune system (in particular Tregs) have a propensity to attack the myelin sheath on their neural axons.
Last edited by CVfactor on Thu Apr 28, 2011 5:50 pm, edited 2 times in total.
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Postby CVfactor » Mon Feb 28, 2011 7:04 pm

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Vitamin D3 & NGF - Nerve Growth Factor

Postby jackD » Tue Mar 01, 2011 1:18 am

One of the nice things about Vitamin D3 is that it is "a potent producer of NGF -Nerve Growth Factor".

This stuff is really GREAT for those small MS brain repair jobs.

Warning !!!! Warning!!! Warning!!!

ONLY THE TRUELY PREVERTED should visit this Web Site!!@!

http://www.copewithcytokines.de/cope.cgi?key=NGF

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Insight into link between sunlight, vitamin D3, MS risk

Postby MSUK » Fri Mar 04, 2011 7:25 am

Image


New research into the neurodegenerative disease, Multiple Sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research, published in the European Journal of Immunology, studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of autoimmunity in an experimental model.

Expensive first-line treatments for MS modestly reduce the frequency of autoimmune attacks but do not slow disease progression, when the patient's immune system operates against the body's own tissues. More expensive second-line treatments slow disease progression but carry high risks. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334
MS-UK - http://www.ms-uk.org/
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Postby Apuman » Fri Mar 04, 2011 4:39 pm

Thanks for sharing this info. It seems to me that if there's one thing that we can put our money on with MS, it's that vitamin D plays a crucial role. The last two doctors I saw were worlds apart with thier ideas... One was a neuro who told me he wanted me on CRABS asap, the other was an MD who also practices eastern medicine. What was the one thing that they both told me was important? You guessed it...
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Postby Wonderfulworld » Sat Mar 05, 2011 5:01 am

Thanks great to see that VitaminD3 can help those of us who have already got MS, not just pre-diagnosis. Thanks for posting this!
~~~~~~~~~~~~~~~
Concussus Resurgo
~~~~~~~~~~~~~~~
RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Tecfidera, Cymbalta, Baclofen.
EPO, Fish Oils, Vitamin D3 2000 IU, Magnesium, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle, Melatonin.
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Postby Leonard » Sat Mar 05, 2011 10:59 am

I invite you to have a look at this thread
http://www.thisisms.com/ftopict-15188.html
my posting from 30 Jan 6:11am

quote: the relation of MS and Vitamin D is well known. High Vitamin D during the time your mother was pregnant from you and your youth (in the period your cells were growing) reduces the risk for MS. The intra-cellular calcium will be lower if there was a high Vitamin D level; conversely, the intra-cellular calcium will be elevated if there was a lack of Vitamin D. Sustained elevations of intracellular calcium may inhibit insulin-target cells from sensing the brisk intracellular calcium fluxes necessary for insulin action, such as in particular glucose transport. See this recent article in the International Journal of Endocrinology:
http://www.hindawi.com/journals/ije/2010/351385.html

I believe that here is the real explanation for the Vit D relationship.
Whether additional Vit D later on helps or not is less clear: I have seen reports to both sides. It seems Vit D does have an immuno-modulating effect.
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Postby jimmylegs » Sat Mar 05, 2011 11:17 am

in the early days when i was trying to decide if i'd take rebif or not, i found a study that basically said that 1,25 dihydroxycholecalciferol had similar biochemical action to interferon. try as i might i cannot find that study again but i sure wish i could.
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Postby Wonderfulworld » Sat Mar 05, 2011 11:32 am

JL it's not this is it? http://bloodjournal.hematologylibrary.o ... 06/13/4351 - it's the opposite though, with Interferon Gamma being surpressed by D3....?
~~~~~~~~~~~~~~~
Concussus Resurgo
~~~~~~~~~~~~~~~
RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Tecfidera, Cymbalta, Baclofen.
EPO, Fish Oils, Vitamin D3 2000 IU, Magnesium, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle, Melatonin.
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