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New research into the neurodegenerative disease, Multiple Sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research, published in the European Journal of Immunology, studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of autoimmunity in an experimental model.
Expensive first-line treatments for MS modestly reduce the frequency of autoimmune attacks but do not slow disease progression, when the patient's immune system operates against the body's own tissues. More expensive second-line treatments slow disease progression but carry high risks. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334
Thanks for sharing this info. It seems to me that if there's one thing that we can put our money on with MS, it's that vitamin D plays a crucial role. The last two doctors I saw were worlds apart with thier ideas... One was a neuro who told me he wanted me on CRABS asap, the other was an MD who also practices eastern medicine. What was the one thing that they both told me was important? You guessed it...
quote: the relation of MS and Vitamin D is well known. High Vitamin D during the time your mother was pregnant from you and your youth (in the period your cells were growing) reduces the risk for MS. The intra-cellular calcium will be lower if there was a high Vitamin D level; conversely, the intra-cellular calcium will be elevated if there was a lack of Vitamin D. Sustained elevations of intracellular calcium may inhibit insulin-target cells from sensing the brisk intracellular calcium fluxes necessary for insulin action, such as in particular glucose transport. See this recent article in the International Journal of Endocrinology:
I believe that here is the real explanation for the Vit D relationship.
Whether additional Vit D later on helps or not is less clear: I have seen reports to both sides. It seems Vit D does have an immuno-modulating effect.
in the early days when i was trying to decide if i'd take rebif or not, i found a study that basically said that 1,25 dihydroxycholecalciferol had similar biochemical action to interferon. try as i might i cannot find that study again but i sure wish i could.
that's pretty close, ww, well done! but not quite the one i remember. maybe if i throw that in pubmed and check out related studies it'll come up.
but yes it's getting at similar stuff, basically this is the kind of info that makes me think of 1,25dihydroxycholecalciferol as part of the immune system's 'brakes'. if you don't have enough 25(OH)D3 you don't have good stores for building 1,25dihydroxycholecalciferol, so if the immune system says 'attack' there's not enough 'stop attacking' messaging going on at the same time.
"macrophages can produce 1,25(OH)2D3 on activation with interferon (IFN-)"
"1,25(OH)2D3 can selectively suppress key effector functions of IFN-–activated macrophages"
"production of 1,25(OH)2D3 by IFN-–stimulated macrophages might be an important negative feedback mechanism to control innate and inflammatory responses of activated macrophages"
http://www.ncbi.nlm.nih.gov/pubmed/14718698 "The mechanisms of these favorable effects of vitamin D are not entirely known but could be related to the ability of 1,25(OH)2D3 to inhibit
the production of the Th1-associated cytokines interleukins-12 and 2, interferon-gamma, and tumor necrosis factor-alpha, thus suppressing the development and proliferation of the inflammatory Th1 cells."
it was something like this one:
http://www.springerlink.com/content/x40311257k3t3005/ "1α,25(OH)2D3 inhibited the expression of nuclear factor of activated T cells c1 (NFATc1, also referred as NFAT2), an essential transcription factor for osteoclast differentiation, and upregulated the expression of interferon-β (IFN-β)"
that still isn't the one though. :S
i'd say the dosage varies widely depending on each individual's present D3 status, level of absorption (mine varies widely depending on zinc status) ... from what i understand once an optimal level around (~125-150 has been suggested) has been attained, 4000IU/d can be considered a maintenance dose, again, depending on individual dose-response. and level of sun exposure with associated variations by age, skin colour, etc.
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