all things vitamin D

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Postby CVfactor » Sun Mar 13, 2011 3:40 pm

Here is a good review article on the impact of Vitamin D on regulatory T cells:

http://www.ncbi.nlm.nih.gov/pubmed/21104171

You may notice that this is written by researchers investigating asthma, but they come to the same conclusions as reaserachers investigating other disease: Tregs are responsible for self tolerance.

Here is another article with the same conclusions:

http://www.cell.com/abstract/S0092-8674%2808%2900624-7

Here is a article from our freinds at the drug company Roche that looks at Vitamin D (analogs of course), Tregs and diabetes:

http://www.roche.com/pages/downloads/science/pdf/rtdcmannh02-3.pdf
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MS 'link' to vitamin D deficiency may be studied

Postby MSUK » Fri Mar 25, 2011 2:20 am

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The MS Society is considering carrying out research in Scotland on a possible link between vitamin D deficiency and Multiple Sclerosis.

A report has called for more research on the role of vitamin D, and highlighted that Scotland is an ideal candidate country for the study.

Scotland has high levels of both vitamin D deficiency and MS.

The MS society wants to establish an international group of experts to carry out the research.

Last year, the MS Society hosted a summit in Glasgow on vitamin D and MS............... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334
MS-UK - http://www.ms-uk.org/
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Postby Bethr » Fri Mar 25, 2011 11:55 am

I wonder if they will also look at this angle, considering the genetic results from the IVSND conference. 1 in 7 Scots carry an iron over load HFE gene. As for the other genes named at the conference, well who knows.

Low serum 25-hydroxyvitamin D in hereditary hemochromatosis: relation to iron status.Chow LH, Frei JV, Hodsman AB, Valberg LS.

Abstract
Under normal conditions, vitamin D absorbed from the diet or synthesized in the skin is transported to the liver where it undergoes hydroxylation. The purpose of this study was to determine whether excess hepatic iron affects this process and the subsequent production of 1,25-dihydroxyvitamin D (1,25-[OH]2D) in the kidney. Mean serum 25-hydroxyvitamin D (25-OHD) concentrations in untreated hereditary hemochromatosis were 13 +/- 6 (SD) in 9 patients with cirrhosis, 13 +/- 6 in 5 patients with hepatic fibrosis, and 22 +/- 6 in 10 patients with normal hepatic architecture aside from siderosis and were significantly lower than the levels found in 24 controls matched for age, sex, and season, p less than 0.05. The mean serum 25-OHD levels in the two groups with hemochromatosis and hepatic damage were significantly lower than the value in the group with normal hepatic architecture, p less than 0.05. Serum 25-OHD levels in individual patients were inversely related to the size of body iron stores as measured by exchangeable body iron, r = -0.64, or serum ferritin, r = -0.47, p less than 0.05. In 15 patients removal of excess body iron by venesection therapy produced a significant increase in the mean serum 25-OHD from 20 ng/ml to 30 ng/ml, p less than 0.05. In contrast, mean serum 1,25-[OH]2D levels were similar in iron-loaded and control subjects, indicating that the regulation of this metabolite was intact in patients with hemochromatosis. The results reveal that the low serum 25-OHD concentration in patients with hemochromatosis is directly related to the extent of iron loading and it is improved by venesection therapy.

PMID: 3838288 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/pubmed/3838288
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Worldwide vitamin D call to action

Postby MSUK » Thu Mar 31, 2011 11:28 pm

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An international consortium of vitamin D experts published a new call to action to address the worldwide vitamin D deficiency in the latest journal of Public Health Nutrition due to their observations that the recent IOM (Institute of Medicine) report was ‘deficient’.

Ten members of the GrassrootsHealth Call to Action Panel wrote letters indicating their points of view. “The potential benefits of vitamin D were underemphasized while overstating the evidence for potential harm” from Edward Giovannucci, Harvard; “People consistently take a supplement, first and foremost, because that supplement makes them feel better. They will continue to take vitamin D.” from John Cannell, Vitamin D Council; “The IOM’s latest recommendations are largely inconsequential. The IOM committee ignored the consensus of hundreds of vitamin D research scientists and nutritionists from at least twenty-five countries” wrote Anthony W. Norman, Emeritus Professor, University of California Riverside.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334
MS-UK - http://www.ms-uk.org/
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Postby CVfactor » Mon Apr 04, 2011 5:30 pm

Here is another good review article on regulatory T cells:

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2009.02308.x/pdf

So, from all of the information I have provided in this thread it looks like the following may be true of multiple sclerocis:

1. MS is caused by a defect in the regulatory T lymphocyte function, in particular the master control gene FOXP3.

2. There are certain pro-inflamitory T-cells that target autoatigens within the central nervous system such as meylin basic protein. Usually, a regulatory T-cell of the same phenotype in a healthy subject will prevent an autoimune response on this tissue.

This is why people with a defective blood brain barrier but a healthy regulatory T-Cell function do not acquire multiple sclerosis.

3. In a normal person, natural regulatory T-cells (nTregs) are developed in the thymus. However, induced regulatory T-cells (iTregs) can be developed outside of the thymus, and it appears vitamin D plays a key role in iTreg development.

Here is another article with additional information:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526254/pdf/imm0125-0001.pdf

This is a topic that is being heavilly researched by immunologists.
The vast majority of these researchers are working on not for profit grants, so in my opinion it is very disrespectful to label these people as being pawns of the drug companies and are only doing this for their own financial gain.

Thousands of people are working on this aspect of the immune system, and I for one would like to thank them for their hard work.
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Vitamin D and vascular health/high blood pressure study

Postby Selmahope » Wed Apr 06, 2011 10:20 am

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Postby CVfactor » Wed Apr 06, 2011 4:54 pm

Here is a new article that investigates regulatory T-cells in the cerebral spinal fluid and new lesions in MS patients:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017988

They find that regulatory T-cells (Tregs) are deficient in MS CSF and lesions compared to healthy people.

This mountain of evidence on regulatory T-cells, MS and vitamin D seems hard to ignore for any logical person in my opinion.

This is more than just a hypothesis.
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MAJ calls for routine vitamin D testing in pregnancy

Postby MSUK » Tue Apr 12, 2011 2:03 am

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Many individuals have been calling for increased recognition of the vitamin D deficiency epidemic in Western countries due to sun avoidance, but have not been heeded by mainstream health authorities.

This editorial in Australia's premier medical journal brings to the fore the issue of vitamin D deficiency during pregnancy, a critical issue for the development of autoimmune diseases like type 1 diabetes and multiple sclerosis, among other diseases.

Prominent Australian endocrinologist Professor Peter Ebeling, in commenting on a paper published in this week's issue of the MJA showing that 41% of pregnant women screened were deficient in vitamin D (at the very conservative level of 50nmol/L or less), called for routing screening for vitamin D in pregnancy.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334
MS-UK - http://www.ms-uk.org/
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Postby CVfactor » Tue Apr 12, 2011 4:48 pm

Here is a good video discussion of Regulatory Tcells and immune tolerance by a researcher involved in diabetes research:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565852/

But the regulatory T cell and self tolerance seems to pertain to all autoimmune diseases.

This guy doesn't seem like a money grubbing patsy of big pharma, he seems more interested in trying to help people in my view.

Note: adaptive tregs (atreg) = induced treg (itreg) = tr1 cells.

I think there is more than enough data here to sticky this thread.

People with an open mind may find this information helpful.
Last edited by CVfactor on Thu Apr 28, 2011 6:40 pm, edited 2 times in total.
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Postby francisco » Wed Apr 13, 2011 4:27 am

Vitamin D is a fat-soluble it helps your body absorb calcium, which your bones need to grow. If lack of vitamin D can lead to bone diseases .
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Postby mrbarlow » Wed Apr 13, 2011 9:00 am

vivavie wrote:Jimmy, I take vitamin D 1000 UI morning and night. I never saw any difference, I take it as a "precaution". Maybe you can explain me the difference between D and D3, should I switch?

Paulmur mentionned 20 000mg/day, isn't that very high???
Thank you
S


This is purely anecdotal but when I feel my symptoms coming on (blurry eye, twitchy nerves and itching) I take a megadose of Vit D (10,000 iu), 1 gram of fish oil, and 500mg of inosine and this seems to help. Maybe placebo but we know those 3 compounds help at a cellular level.
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Postby jimmylegs » Wed Apr 13, 2011 9:58 am

i take d3 10,000IU at a time too. fish oil is great, i take a gram a day. i bought some flax oil for omega 3s too, but haven't really started using it yet.
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
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Postby mrbarlow » Wed Apr 13, 2011 11:45 am

jimmylegs wrote:i take d3 10,000IU at a time too. fish oil is great, i take a gram a day. i bought some flax oil for omega 3s too, but haven't really started using it yet.


I read that plant based omega 3's are pretty pointless as we convert less than 5% to long chain Omega 3 which we (humans) can actually utilise.
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Postby jimmylegs » Wed Apr 13, 2011 12:27 pm

yea i definitely rely more on the fish oil for omega 3... but i don't want to use it when i make salad dressing LOL
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
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Postby CVfactor » Tue Apr 19, 2011 4:09 pm

So, to tie this all together, here is an article relating vitamin D, viral influences and regulatory T cells in one hypothesis for the cause of multiple sclerosis:

http://www.ncbi.nlm.nih.gov/pubmed/18387750

For me, I have been taking 40,000 IU/day since october. My 25-hydroxyvitamin blood level is 250 nmol/L. This level would be considered toxic by most doctors, which means that your calcium level would be too high.

However, my blood serium calcium level is 9 mg/dL which is on the low end of the normal scale.

Since I have been taking this level of Vitamin D, I have not had any significant relapses. I should note that I first started out at 15,000IU/day last summer and continued to have relapses (hand tremmors, optic neuritis, double vision, difficulty saying what I was thinking). I kept increasing the dosage until I reached 25,000.

In October of last year, I had a bad instance of optic neuritis and I increased my dosage to the Lowest Observed Adverse Effect Level (LOAEL) which is estimated to be 40,000IU/day.

This is working for me.

At this point, I do not have anything else that I can to this thread.

I hope whoever reads this finds useful information.

I think this is my last post, and I wish you all the best of luck.[url][/url]
Last edited by CVfactor on Thu Apr 28, 2011 5:37 pm, edited 1 time in total.
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