herbals

Discuss herbal therapies, vitamins and minerals, bee stings, etc. here

Postby CureOrBust » Fri Jun 23, 2006 7:50 pm

well, i accidently came accross some more info on it myself.

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.

<shortened url>

ok, so i guess my question now is, has anyone any experience or knowledge of "Iscaria sinclarii"?
User avatar
CureOrBust
Family Elder
 
Posts: 2895
Joined: Wed Jul 27, 2005 3:00 pm
Location: Sydney, Australia

Advertisement

:(

Postby jimmylegs » Fri Jun 23, 2006 8:58 pm

sorry cob, i think i recall looking up the original post item and not finding anything useful.
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 8944
Joined: Sat Mar 11, 2006 4:00 pm

Postby carolew » Sat Jun 24, 2006 7:10 am

fingolimod is FTY720 indeed... :) Carole
User avatar
carolew
Family Elder
 
Posts: 553
Joined: Fri Nov 05, 2004 4:00 pm
Location: Ottawa, Ont. Canada

fungalicious

Postby jimmylegs » Sat Jun 24, 2006 7:57 am

perhaps it is isaria sinclairii, cure? "Isaria sinclairii, a traditional Chinese medicine composed of the fruiting bodies of I. sinclairii and its parasitic host larva" <shortened url>

here is a link to some info, isaria's at the bottom of the list
http://www.hiddenforest.co.nz/fungi/family/clavicipitaceae/clavicipitaceae.htm

also:
so, when you want to read about it in supplement form you look for cordyceps, apparently. this gets far better shopping type results in google than the latin name.
here's where i found the name cordyceps
http://planetherbs-com.site-etc.net/discus/messages/59/490.html?1149367524
and here's one online store selling the supplement but i haven't done really any reading about it and i don't know or use this product or this store:
http://www.1fast400.com/i24_Cordyceps.html

and:

J Antibiot (Tokyo). 1994 Feb;47(2):208-15.
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Chiba K, Hoshino Y, Okumoto T.
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

A potent immunosuppressive activity was found in the culture broth of the fungus Isaria sinclairii (ATCC 24400). The metabolite, ISP-I ((2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2- hydroxymethyl-14-oxoeicos-6-enoic acid, myriocin = thermozymocidin) suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction, but had no effect on the growth of human tumor cell lines. It also suppressed the appearance of plaque-forming cells in response to sheep red blood cells and the generation of allo-reactive cytotoxic T lymphocytes in mice after intraperitoneal or oral administration. The metabolite was 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo, and appears to be a candidate for clinical application as a powerful immunosuppressant.
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 8944
Joined: Sat Mar 11, 2006 4:00 pm

Postby CureOrBust » Sat Jul 08, 2006 12:28 am

I got my hands on some "Cordyceps". When I first opened the pack, something smelt very familiar. NOW i have realized that the capsules smell like chocolate cake mix!
User avatar
CureOrBust
Family Elder
 
Posts: 2895
Joined: Wed Jul 27, 2005 3:00 pm
Location: Sydney, Australia

cordyceps with frosting

Postby jimmylegs » Sat Jul 08, 2006 4:59 am

sweet! glad you found some :)
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 8944
Joined: Sat Mar 11, 2006 4:00 pm

Ginseng--Fatigue Trial and for Neuroprotection?

Postby Shayk » Thu Aug 31, 2006 7:30 pm

Hi all

VerminSquibble mentioned a possible ginseng trial for fatigue in another thread. Here’s a link to a little bit of info about that trial. You have to scroll down a bit to find it.

The ginseng trial is also mentioned, along with other familiar (omega 3’s, yoga, Swank Diet), complementary approaches in another very understandable (IMO) presentation from the MS Care Consortium Conference in June 2006.

Future Research in CAM and MS by V. Yadav, M.D.

And, here are a couple of abstracts about ginseng and gensenosides. Besides possibly helping with fatigue, it also seems to have the potential to provide some neuroprotection via several mechanisms, including “ameliorating” mitchondrial dysfunction, that’s been discussed recently.

Use of Ginseng in Medicine with Emphasis on Neurodegenerative Disorders
recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms.


I know the “immune-stimulatory” activities mentioned there will be of concern to some and I’m sorry I really don’t have any more info about that. Now to the second abstract,

Protective Effect and Mechanism of Ginsenosides on CNS in Animals
The mechanism of the protective effect on CNS involves the effects on calcium channel blockade, glutamate and gamma-aminobutyric acid, antiperoxidation, estrogen-like action, nitric oxide and its synthase, also the inhibition on cerebral nerve cell apoptosis and amelioration on mitochondrial dysfunction, etc.


Ginseng just might turn out to be a winner for people with MS. :) It's nice to know there is a trial.

Sharon
User avatar
Shayk
Family Elder
 
Posts: 777
Joined: Fri Feb 06, 2004 4:00 pm

Postby verminsquibble » Fri Sep 01, 2006 6:07 am

Shayk,
I had read about the trial for ginseng off of the NMSS website, but was unaware of the details until you had posted them. It looks like the trial will be using American Ginseng , which is different from Panax Ginseng (also known as Asian Ginseng).

Use of Ginseng in Medicine with Emphasis on Neurodegenerative Disorders
recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms.


I know the “immune-stimulatory” activities mentioned there will be of concern to some and I’m sorry I really don’t have any more info about that. Now to the second abstract,

Protective Effect and Mechanism of Ginsenosides on CNS in Animals
The mechanism of the protective effect on CNS involves the effects on calcium channel blockade, glutamate and gamma-aminobutyric acid, antiperoxidation, estrogen-like action, nitric oxide and its synthase, also the inhibition on cerebral nerve cell apoptosis and amelioration on mitochondrial dysfunction, etc.



The neuroprotective effects from the studies you provided the abstracts for looked at Panax Ginseng. You can read a little from the links I provided that American and Panax Ginseng have different properties. One of the studies directly states that it looked at Panax Ginseng, and while the other did not my inclination it to believe that it also did as it was published in a Chinese journal. The long and short of it all is that I wouldn't be surprised if the trial looking at American Ginseng for fatigue in MS will find little or no effect. They need to be looking at the Panax variety.

VS
User avatar
verminsquibble
Getting to Know You...
 
Posts: 11
Joined: Wed Jun 28, 2006 3:00 pm
Location: South Florida

The Effect of ginkgo biloba on MS

Postby Kt » Wed Sep 06, 2006 6:35 am

I used to take ginkgo biloba suplements and found they had an impact on my concentration and overall mood.

I found that I could concentrate on something for a significantly longer period of time and didn't get bored so easily. I need to start taking them again! On the flip side, my health had deteriated to a point where I couldn't drive or walk, even with 2 sticks and I couldn't say if the ginkgo biloba supplements helped me to start getting better or if it was down to the Omega 3 oils or the change in exercise routine but I started drving again and walking with 1 stick. However I recently made huge changes to my diet and started taking Glyconutrients. I can walk significantly further with 1 stick and more steps with no aids and generally feel significantly better but I have recently stopped working, which has meant that my stress load is significantly less.

Whatever it is I am not going to go back to my old diet or stop taking the GlycoNutrients now.
User avatar
Kt
Newbie
 
Posts: 9
Joined: Wed Jul 19, 2006 3:00 pm
Location: Bath, UK

brain food

Postby jimmylegs » Wed Sep 06, 2006 6:41 am

i'm a total tard without my ginkgo!
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 8944
Joined: Sat Mar 11, 2006 4:00 pm

Postby Kt » Wed Sep 06, 2006 7:27 am

I will start taking it again! BUT I wouldn't say that I went downhill when I stopped taking the Ginko. It was all the other enviromental factors that were the accelarator for my sudden and dramatic decline 3years ago. The climb back to normality is proving to be very slow and discouraging at times. Without my man I wouldn't be as far up this drasted hill as I am.

Where do you get your Ginko from?
User avatar
Kt
Newbie
 
Posts: 9
Joined: Wed Jul 19, 2006 3:00 pm
Location: Bath, UK

no special place

Postby jimmylegs » Thu Sep 07, 2006 12:06 am

i just get it from one local shop or other. i think the ones i have now were just in the health food section at the grocery!
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 8944
Joined: Sat Mar 11, 2006 4:00 pm

Postby jim4030 » Sun Nov 05, 2006 9:09 pm

Toooooo bad would not be able to get the "pleasant buzz".. :twisted: ... that would be really nice to get this "pleasant Buzz" but no side effect with the reseach ... hahaha.. would it not be nice to be out of letargy too.. hahaha...
:twisted:
User avatar
jim4030
Getting to Know You...
 
Posts: 18
Joined: Wed Oct 04, 2006 3:00 pm

Postby Melody » Mon Nov 06, 2006 5:59 am

quote="CureOrBust"]

He said that without it, his spacicity would make doing almost anything impossible. I was wondering if others who have tried it, have you noticed reduced spacicity? Without severe lethargy added by the drug?[/quote]


I know a few people on it actually quite a few some are on sprays other's grow their own and some prescribed smoke. I've noted severe lethargy in some and as usual with that specific drug you also get the ones it appears to calm down. All in all I think it likely depends on metabolism. If you have always been fidgety and hyper it MIGHT help you. If you are laid back IMO it won't. Keep in mind it makes you anxious when smoked much the same as cigs and is a toxin. John smoked for years and he only stopped when he had health issue's and we were removing toxins. John was always on the hyper side so it calmed him down. The odd thing is he is no longer hyper so it that what caused him to appear hyper for years? I don't know and as usual more questions then answers.


Now Ian it could well be the English equivalent to drinking us Canadian girls pretty. :lol: :lol: :lol:
John was diagnosed Jan 2005. On lipitor 20mg .On Copaxone since July 4,2005. Vitamin D3 2000iu-4000iu (depending on sunshine months)June 10 2005(RX::Dr. O'Connor) Omega 3 as well Turmeric since April 2005. Q10 60mg. 1500mg liquid Glucosamine Nov 2005.
User avatar
Melody
Family Elder
 
Posts: 431
Joined: Sun Apr 03, 2005 3:00 pm
Location: Ontario Canada

Postby Loobie » Mon Nov 06, 2006 1:13 pm

I smoke it for relief of spasticity and bladder function. I've done many experiments with quitting and seeing how it goes. I'm firmly convinced that it helps me alot. I have to admit that I worry about the addiction. It is addictive. Even if it is only mildly addictive in that you don't get physical symptoms; just intense cravings like when you try to quit ciggys.

I had quit one time for 4 months and my bladder function steadily declined until I smoked again. I'm not kidding. It's one of those razor's edge things. If you play too much, it will bite you, but if you use it when you need to, it is very helpful.

And as Forrest says: "That's all I have to say about that".
User avatar
Loobie
Family Elder
 
Posts: 2196
Joined: Mon Sep 11, 2006 3:00 pm
Location: Dayton, Ohio USA

PreviousNext

Return to Natural Approach

Who is online

Users browsing this forum: No registered users