http://www.ncbi.nlm.nih.gov/pubmed/11937096Eur J Pharmacol. 2002 Mar 29;439(1-3):83-92.
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Brooks JW, Pryce G, Bisogno T, Jaggar SI, Hankey DJ, Brown P, Bridges D, Ledent C, Bifulco M, Rice AS, Di Marzo V, Baker D.
Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK.
Activation of cannabinoid receptors causes inhibition of spasticity, in a mouse model of multiple sclerosis, and of persistent pain, in the rat formalin test. The endocannabinoid anandamide inhibits spasticity and persistent pain. It not only binds to cannabinoid receptors but is also a full agonist at vanilloid receptors of type 1 (VR1). We found here that vanilloid VR1 receptor agonists (capsaicin and N-N'-(3-methoxy-4-aminoethoxy-benzyl)-(4-tert-butyl-benzyl)-urea [SDZ-249-665]) exhibit a small, albeit significant, inhibition of spasticity that can be attenuated by the vanilloid VR1 receptor antagonist, capsazepine. Arvanil, a structural "hybrid" between capsaicin and anandamide, was a potent inhibitor of spasticity at doses (e.g. 0.01 mg/kg i.v.) where capsaicin and cannabinoid CB(1) receptor agonists were ineffective. The anti-spastic effect of arvanil was unchanged in cannabinoid CB(1) receptor gene-deficient mice or in wildtype mice in the presence of both cannabinoid and vanilloid receptor antagonists. Likewise, arvanil (0.1-0.25 mg/kg) exhibited a potent analgesic effect in the formalin test, which was not reversed by cannabinoid and vanilloid receptor antagonists. These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically.
PMID: 11937096 [PubMed - indexed for MEDLINE
Algis wrote:Wasn't Sativex supposed to do the same - Without the smoking and legal problem? But I can't judge since we do not have Sativex here.
jimmylegs wrote:from world's healthiest foods site:Linoleic acid is an omega-6 fatty acid which is plentiful in the diet of most Americans. This fat is found in at high levels in oils from grains, nuts and legumes, and is often provided in your diet by sunflower, safflower, sesame, corn, soy, and peanut oils. In the body, linoleic acid is first converted to another omega-6 fat called gamma-linolenic acid, which is also found in evening primrose oil and borage oil.
yigalby wrote:i work with evening primrose oil (EPO) for the last 4 years.
it work so good in many conditions (cholesterol, baldnessanxiety, pms, acne, skin problems..).
i use fresh flower and leaves soaked in olive oil.
the leaves is BtW acording to dr duke is the best source of natural quercetin.
and its known by some herbalist here to help with MS
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