all things magnesium

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Re: all things magnesium

Postby jimmylegs » Wed Oct 18, 2017 6:16 pm

Concentration of magnesium in the serum and the ability status of patients with relapsing-remitting multiple sclerosis.
https://www.cabdirect.org/cabdirect/abs ... 0173157407
Abstract : Multiple sclerosis (MS) is the most common autoimmune disease affecting the central nervous system, characterized by the presence of scattered foci of demyelination in the brain and spinal cord. Magnesium (Mg) has a significant influence on the nervous system and the immune system. The aim of this study was to evaluate the influence of the concentration of Mg in the serum on the ability status of patients with MS. The study group consisted of 101 adults with diagnosed relapsing remitting MS. All participants were investigated on the Expanded Disability Status Scale. The control group included 41 people. The concentration of Mg in the serum was determined by the flame atomic absorption spectrometry method. The patients completed a survey and a 24-hour dietary interview. In patients with MS, the percentage of respondents with normal magnesium content was significantly lower than in the control group (p<0.05). The study proved that patients with normal Mg serum concentration levels were in better clinical condition, particularly with respect to the function of the pyramidal tract (p=0.007) and sphincters (p=0.002), than patients with inadequate levels of Mg in the serum. External factors such as gender, smoking, immunomodulating medications or dietary supplements of Mg were found to have no effect on the concentration of Mg in the serum of MS patients. The results of our study suggest that an abnormal concentration of Mg in the serum of MS patients should be recognized and corrected, as this may improve the health status of people with MS.

can't get into the full text yet apparently. so, will just have to wait a bit and see if eventually we can get a look at some more detailed numbers :)

update: full text available at http://jsite.uwm.edu.pl/index/getfile/1156/

interesting: "The Mg content in the serum should range from 0.700 to 1.000 mmol L-1
(Neumeister et al. 2013)." range goes to 1.05 or 1.1 depending which lab you visit locally

study indicates that patients with technically elevated as well as suboptimal levels also were worse off, and -oddly to my mind- it appears the researchers have not excluded ppl taking magnesium supplements.
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Re: all things magnesium

Postby NHE » Wed Oct 18, 2017 11:34 pm

jimmylegs wrote:External factors such as gender, smoking, immunomodulating medications or dietary supplements of Mg were found to have no effect on the concentration of Mg in the serum of MS patients.

So Mg supplements made no difference? That's surprising.
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Re: all things magnesium

Postby jimmylegs » Thu Oct 19, 2017 3:19 am

yeah. will need full text to see if we can get more detail on things like:

-the details on the patients vs controls at baseline
-what background *dietary* mag intake was vs that from any supplements
-what counted as mag supps (how many mgs? what forms used?)
-what's being used as cutoff for normal vs below normal
-whether or not d3 intake or other possible confounders were accounted for,
-whether daily total mag intake met/exceeded daily requirements or not,
-can we actually see mean serum levels for subjects with and without mg supplements,

etc.

fwiw, i have the lab tested differences my dietary x supplemental mag regimen has made to my serum levels during recovery from d3 toxicity. and i know i feel much better. i'll need to read up on pyramidal tract and sphincter dtls however - haven't seen those specifically mentioned before. i've speculated here that high and/or low mag could be affecting things like the LES, so will be interesting to have a closer look if this article ever shows up in my library.

while we're having a go at the abstract, they should not have said this study 'proved' anything. probably an ELL thing. the journal web site looks pretty low capacity. my go to library doesn't appear to subscribe. i can get at full text for a cu/zn ratio in ms study which these researchers have had published in j. nutrition, but not for this mag study in j. elementology.
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Re: all things magnesium

Postby jimmylegs » Mon Oct 30, 2017 7:50 am

good read: whqlibdoc.who.int/publications/2009/9789241563550_eng.pdf

excerpt: "Lowenstein and Stanton (1986) established the reference interval (central 95th percentile) for the serum magnesium concentration of 0.75–0.955 mmol/l. ... we do not know what percentage of this population had an inadequate intake of magnesium and may have been magnesium deficient. Thus, the lower limit of the reference interval may have been flawed by having subjects in the “normal” population that were deficient in magnesium."

yeah, and/or the upper limit...

https://www.ncbi.nlm.nih.gov/pubmed/12486495
"The mean serum magnesium level among subjects with metabolic syndrome was 1.8±0.3 mg/dl, and among control subjects 2.2±0.2 mg/dl, p<0.00001."

so upper end of that control group (without reading the fine print i would interpret this group not as optimally healthy necessarily, but free of met syndrome) is sitting at se mg 2.4 mg/dl or 0.99 mmol/l

http://europepmc.org/abstract/med/12693452
"Mean serum magnesium at baseline in the diabetic patients was significantly lower than that in controls (1.44 +/- 0.48 mg/dl Vs 2.29 +/- 0.33 mg/dl; p < 0.001)."
upper end of control group 2.6 or 1.1 - again have not looked at the details but suspect that controls will need only to be free of diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/3827422
"the mean level (2.5±0.4 mg/dL [1.03 ± 0.16 mmol/L]) in a reference population of healthy volunteers was unexpectedly high"
and again, upper end of healthy vol gp 2.9 or 1.2

interesting, levels highest where researchers actually specified 'healthy' controls - will be worth a closer look at how that group was selected.

ppl need to stop saying that serum mag is a bad test. as researchers have stated, it's the reference range and results interp that need work.
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Re: all things magnesium

Postby jimmylegs » Tue Oct 31, 2017 7:51 am

SO. MUCH. YES. *tear *snif

Interpreting magnesium status to enhance clinical care: key indicators (Nov 2017)
http://bit.ly/2hqsna1

"Purpose of review: To update advances in identifying factors affecting magnesium (Mg) status that assist in providing improved evidence-based clinical decision-making for assessing Mg status.

Recent findings: Findings from recent cohort studies, small randomized control trials, and multiple meta-analyses reinforce earlier work that serum Mg concentrations, urinary Mg excretion, and Mg dietary intakes are inversely associated with cardiovascular disease, chronic kidney disease, and diabetes. These studies indicate that the reference range for serum Mg needs updating, and that individuals with serum Mg in the range of 0.75–0.85 mmol/l and displaying changes in other factors associated with a low Mg status may be Mg deficient. Individuals with serum Mg concentrations below this range most likely are Mg deficient and, above this range, are most likely Mg sufficient.

Summary: The combined determination of serum Mg concentration, 24-h urinary Mg excretion, and dietary Mg intake is currently the most practical method to obtain a sound assessment of Mg status. The strong correlations of Mg deficiency with increased risk of several chronic diseases, some of which exist as comorbidities, indicate that Mg status should be ascertained in patients presenting such disorder."


always keeping in mind, however: http://bit.ly/2h067Xz

"at a cut off of 0.90 mmol/L, only 1% of the individuals had clinical magnesium deficiency"
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Re: all things magnesium

Postby jimmylegs » Tue Oct 31, 2017 8:09 am

this here is why 'normal' serum mag needs to change. wtf.

Extensive Intracranial Calcification in a Case of Hypoparathyroidism: Case Report (2017)
http://irjns.org/browse.php?a_id=80&sid ... =en&html=1
Abstract
Background and Importance: Hypoparathyroidism is due to parathyroid hormone deficiency and categorized as an endocrine disorder. Acute clinical presentations of hypoparathyroidism are muscle cramps and spasms, tetany, weakness, paresthesia and seizure. Hypoparathyroidism may be accompanied with psychosis, depressio n, seizures and extrapyramidal manifestations in chronic condit ion.
Case Presentation: The present case reported about a 37-year-old man who presented with the history of several episodes of seizures, slurred speech, progressive limbs and trunk stiffness and increased muscle tone and rigidity.
Conclusion: Paraclinical investigations revealed hypocalcemia and very low parathyroid hormone levels with extensive intracranial calcification involving bilateral basal ganglia, cerebellum and subcortical white matters on brain CT scan.
...
"There was no abnormality in serum electrolytes. His serum albumin was 4.4 g/dl. Serum electrolyte analysis showed sodium 139 mEq/l (Nl range: 135-145 mEq/l), potassium 3 mEq/l (Nl range: 3.5-5.3 mEq/l), calcium 6.6 mg/dl (Nl range: 8.0-10.4 mg/dl), serum phosphate 4.2 mg/dl (Nl range: 2.5-4.5 mg/dl), and serum magnesium was 1.8 mg/dl (Nl range: 1.3-2.5 mg/dl).

that's 0.74 mmol/l by the way. <font=sarcastica>mm hmm yeah sure buddy that's 'normal'. oh and 0.53 mmol/l is a great lower cutoff for your local 'normal' range. nothing to see here in your electrolyte results. such mysterious calcification issues what to do, what to do! </sarcastica>
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Re: all things magnesium

Postby jimmylegs » Wed Nov 08, 2017 2:52 pm

aw yisss public health meet clinical care:

The Importance of Magnesium in Clinical Healthcare
https://www.hindawi.com/journals/scient ... 79326/abs/

Abstract
The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium repletion in diverse medical conditions. Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for magnesium, a deficiency problem contributing to various health conditions. This review assesses available medical and scientific literature on health issues related to magnesium. A traditional integrated review format was utilized for this study.
Level I evidence supports the use of magnesium in the prevention and treatment of many common health conditions including
migraine headache,
metabolic syndrome,
diabetes,
hyperlipidemia,
asthma,
premenstrual syndrome,
preeclampsia, and
various cardiac arrhythmias.

Magnesium may also be considered for prevention of
renal calculi and cataract formation,
as an adjunct or treatment for depression, and
as a therapeutic intervention for many other health-related disorders
.

In clinical practice, optimizing magnesium status through diet and supplementation appears to be a safe, useful, and well-documented therapy for several medical conditions.

:-D :-D :-D :-D :-D
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Re: all things magnesium

Postby THX1138 » Mon Nov 13, 2017 4:14 am

jimmylegs wrote:aw yisss public health meet clinical care:

The Importance of Magnesium in Clinical Healthcare
https://www.hindawi.com/journals/scient ... 79326/abs/

Abstract
The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium repletion in diverse medical conditions. Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for magnesium, a deficiency problem contributing to various health conditions. This review assesses available medical and scientific literature on health issues related to magnesium. A traditional integrated review format was utilized for this study.
Level I evidence supports the use of magnesium in the prevention and treatment of many common health conditions including
migraine headache,
metabolic syndrome,
diabetes,
hyperlipidemia,
asthma,
premenstrual syndrome,
preeclampsia, and
various cardiac arrhythmias.

Magnesium may also be considered for prevention of
renal calculi and cataract formation,
as an adjunct or treatment for depression, and
as a therapeutic intervention for many other health-related disorders
.

In clinical practice, optimizing magnesium status through diet and supplementation appears to be a safe, useful, and well-documented therapy for several medical conditions.

:-D :-D :-D :-D :-D


Magnesium Excels Against Constipation
https://www.peoplespharmacy.com/2013/03/25/magnesium-excels-against-constipation/
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Re: all things magnesium

Postby jimmylegs » Mon Nov 13, 2017 7:01 am

yes - if taken in an inorganic, insoluble form ie one that is not ideal for absorption into tissue.
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Re: all things magnesium

Postby jimmylegs » Wed Nov 15, 2017 6:09 pm

not the usual magnesium-based 'holy crap!'

Hypermagnesemia-induced fatality following epsom salt gargles1
http://www.sciencedirect.com/science/ar ... 7901004620
Abstract
Hypermagnesemia is a rare cause of coma in a patient with normal renal function. When present, it is often because of iatrogenic medication overdose. We report a fatal case of chronic Epsom salt gargles for halitosis that produced a serum magnesium of 23.6 mg/dL (9.8 mmol/L) and resulted in coma. We review the wide presentation of hypermagnesemia from subtle neurologic and cardiovascular signs to the major life-threatening clinical manifestations of shock, dysrhythmias, coma, and cardiopulmonary arrest despite emergency dialysis.
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Re: all things magnesium

Postby jimmylegs » Sat Nov 18, 2017 8:17 am

a bit of a weird read.

Myth or Reality—Transdermal Magnesium?
free full text http://www.mdpi.com/2072-6643/9/8/813/htm

i havent spent much time with this one so far, but at first glance it seems like the authors are arguing with themselves.
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Re: all things magnesium

Postby jimmylegs » Sun Nov 19, 2017 12:52 pm

i usually use world's healthiest foods for this kind of info, but i like this page now that i've stumbled across it in passing:

Food Sources of Magnesium
https://www.dietitians.ca/your-health/n ... esium.aspx
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Re: all things magnesium

Postby THX1138 » Thu Nov 23, 2017 4:07 am

i usually use world's healthiest foods for this kind of info, but i like this page now that i've stumbled across it in passing:

Food Sources of Magnesium
https://www.dietitians.ca/your-health/n ... esium.aspx

Using both the Chrome browser and the Edge browser, that page did not work for me. The only thing that showed up was the top 1/3 to 1/2 of the page.
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Re: all things magnesium

Postby THX1138 » Thu Nov 23, 2017 4:41 am

jimmylegs wrote:a bit of a weird read.

Myth or Reality—Transdermal Magnesium?
free full text http://www.mdpi.com/2072-6643/9/8/813/htm

i havent spent much time with this one so far, but at first glance it seems like the authors are arguing with themselves.


JL Have you tried magnesium oil :?:


I almost laugh, or something, when I see articles or studies questioning or ?trying? (only 56 mg Mg- come on now.) to determine if magnesium oil is absorbed through the skin.

In fact, I'm considering going to the lab and having a blood draw both pre-magnesium oil treatment and post-magnesium oil treatment. Then I would post the results here and maybe send the results to the drug doctor who confidently told me that magnesium is not absorbed through the skin. :roll: :roll:

It's been over 7 years since I did my first magnesium oil treatment, and from the get-go, especially in the earlier days, it's been as obvious as day that it is well absorbed through the skin.

I think that anyone serious about increasing their magnesium levels (and enjoying the benefits of doing so) would risk the $10 or whatever for a bottle of magnesium oil and see first-hand how it works.
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Re: all things magnesium

Postby jimmylegs » Thu Nov 23, 2017 7:27 am

i made some, tried it, didn't like. i don't have any problem absorbing/retaining dietary/oral mag though.

health regs i was reading yesterday advise no more than 350mg per day via supplementation. not clear if they say that because of mag oxide's laxative effect. probably.

please do conduct and post your n=1 study of serum mag pre and post mag oil treatment!!!

makes sense with your stubborn low mag, even with supplementation, that you would be particularly affected by transdermal and/or IV mag therapy. and of course mag rich fooooods will deliver beneficial cofactors we don't see in isolated mag products. it would be worth figuring out what exactly could be going on there. have you looked at metabolic acidosis?
http://www.sciencedirect.com/science/ar ... 1411000604
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