1) please observe forum rules re advertising and
2) oh my goodness no. uric acid tends to be low in ms patients. have you read the wikipedia uric acid entry wrt MS?
http://en.wikipedia.org/wiki/Uric_acid# ... _sclerosisin my experience, this uric acid problem is associated with the low zinc levels also typically seen in ms patients.
for years my serum uric acid was dead-on or below the ms average of 194. then i suspected and confirmed a zinc deficiency.
i corrected the zinc deficiency, then realized the zinc/uric acid connection and started testing serum Zn and UA together.
at that time i had successfully raised my zinc levels to 16.1 (which approaches the healthy controls average of 18.2). after years of unsuccessfully trying to elevate my serum uric acid via high purine foods (likely skyrocketing my serum ammonia due to broken urea cycle, greeaaat), the zinc therapy finally resulted in a serum uric acid jump to 278 umol/L (approaching the healthy controls range of 290-300).
although it's not the only relevant nutrient where myelin health is concerned, zinc is critical to membrane integrity throughout the human body. the myelin sheath is no exception:
Specificity of zinc binding to myelin basic protein (1995)
http://www.springerlink.com/content/k4621j762u623l22/Abstract
Quote:
Z2+ appears to stabilize the myelin sheath but the mechanism of this effect is unknown. In a previous report we have shown that zinc binds to CNS myelin basic protein (MBP) in the presence of phosphate and this results in MBP aggregation. For this paper we used a solid phase zinc blotting assay to identify which myelin proteins bind zinc. MBP and a 58 kDa band were found to be the major targets of65Zn binding. Moreover, using fluorescence, light scattering and electron microscopy we investigated the binding of zinc and other cations to purified MBP in solution. Among the cations tested for their ability to interfere with the binding of zinc, the most effective were cadmium, mercury and copper, but only cadmium and mercury increased the scattering intensity, whereas MBP aggregation was not inhibited by copper ions. Thus, the effect of zinc on the formation of MBP clusters seems to be specific.
Myelin Basic Protein Is a Zinc-Binding Protein in Brain: Possible Role in Myelin Compaction (1997)
http://www.springerlink.com/content/g11684506347u682/Abstract
Quote:
The zinc-binding proteins (ZnBPs) in porcine brain were characterized by the radioactive zinc-blot technique. Three ZnBPs of molecular weights about 53 kDa, 42 kDa, and 21 kDa were identified. The 53 kDa and 42 kDa ZnBPs were found in all subcellular fractions while the 21 kDa ZnBP was mainly associated with particulate fractions. This 21 kDa ZnBP was identified by internal protein sequence data as the myelin basic protein. Further characterization of its electrophoretic properties and cyanogen bromide cleavage pattern with the authentic protein confirmed its identity. The zinc binding properties of myelin basic protein are metal specific, concentration dependent and pH dependent. The zinc binding property is conferred by the histidine residues since modification of these residues by diethyl-pyrocarbonate would abolish this activity. Furthermore, zinc ion was found to potentiate myelin basic protein-induced phospholipid vesicle aggregation. It is likely that zinc plays an important role in myelin compaction by interacting with myelin basic protein.
low zinc consequences are hypothesized to go beyond the structural integrity of the myelin sheath:
The possible role of gradual accumulation of copper, cadmium, lead and iron and gradual depletion of zinc, magnesium, selenium, vitamins B2, B6, D, and E and essential fatty acids in multiple sclerosis (2000)
Quote:
...low Zn levels result in deficient CuZnSuperoxide dismutase (CuZnSOD), which in turn leads to increased levels of superoxide. ... Vitamin B6 moderates intracellular nitric oxide (NO) production and extracellular Mg is required for NO release from the cell, so that a deficiency of these nutrients results in increased NO production in the cell and reduced release from the cell. The trapped NO combines with superoxide to form peroxinitrite, an extremely powerful free radical that leads to the myelin damage of MS. ...
prenatal vitamin supplementation may be in part responsible for some of the improvement seen in ms patients during pregnancy. there are also some steroid hormone changes (with zinc connections of their own) in the third trimester that affect the immune system. links to '06 discussion
general-discussion-f1/topic3180-15.html#p20496general-discussion-f1/topic3180-30.html#p20560
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He then went on-line and read a meta-analysis article that said it was more associated with PPMS and not RRMS. Either way, he should of been interested to have learned something new about a disease he has been studying/researching for so many years. I have slowly been losing respect for this guy every time I see him.
