Though the results are based on a small number of samples, they give an indication that iron accumulation associated with Alzheimer's appears to involve the formation of strongly magnetic iron compounds
TwistedHelix wrote:This thread is ringing some distant bells with me, (although that could just be the last of my marbles rattling round): because I seem to remember a discussion about carbon monoxide as an MS therapy.
The theory was that because carbon monoxide binds iron to heme molecules in the nervous system, it suppresses the production of free radicals.
There was also research which found that people with PPMS excrete large amounts of iron in their urine, while those with RRMS produce high amounts of aluminium. It certainly looks as if the way we metabolise metals is definitely awry.
Iron dysregulation is implicated in MS. MSers were tested, and their serum levels of iron were fine, BUT they had high levels of the mediator of iron uptake, called "transferrin receptor". Because of this they had more "iron turnover" going on in their brains, more endothelial dysfunction and more oxidative damage.
Iron overload and upregulation of iron-handling proteins, such as TfR, in the MS brain can contribute to pathogenesis of Multiple Sclerosis and iron imbalance is associated with a pro-oxidative stress and a proinflammatory environment, this suggest that iron could be a target for MS therapy to improve neuronal iron metabolism.
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