Vitamin K..how much?

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MrChris
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Vitamin K..how much?

Post by MrChris »

I've read that 120mcg a day is sufficient under normal circumstances. However, how much is recommended for a person taking hi doses of vitamin d..in my case 5000iu of D3 per day? I also want t start taking 500mg of Calcium and 150mg of magnesium.

Also, since i've read mixed review. Can Vitamin k2 induce blood clotting? I ask this because many sites say not to mix vitamin K with anticoagulants. However, they do not specify if its k1, 2 or 3 that they are talking about. From my readings it seems k1 will increase blood platelets.

Any advice would be greatly appreciated.
Last edited by MrChris on Sat Jul 04, 2015 1:42 pm, edited 1 time in total.
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jimmylegs
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Re: Vitamin K..how much?

Post by jimmylegs »

re vit k i would just say keep the dietary greens in the mix. http://www.whfoods.com/genpage.php?tnam ... #foodchart
i'm personally about to enjoy a nice big serving of kale w my dinner. :) mind you, i don't take 5K IU vit d3 any more since suffering the side effects.

i used to try to take calcium but it made my back hurt. haven't had levels done in a while but diet is solid for calcium sources. plenty of dark leafy greens (most often spinach and chard) and plain yog. http://www.whfoods.com/genpage.php?tnam ... #foodchart

150mg mag might be low. how much are you getting from food and fluid daily, and which lifestyle traits do you have (including meds etc), that could deplete mag levels? i eat plenty of mag food sources but still find i need to supplement even more, depending on whatever else might be going on at the time. http://www.whfoods.com/genpage.php?tnam ... #foodchart
if i were you i would consider making sure you got x amount of mag just for you, plus some more to compensate for any negative influences, plus more again to go with the d3. you feel it when you've taken too much in various ways. ime, if it's a cheap form the result is an unpleasantly sudden case of the runs while too much of a high quality form can be felt as a sort of muscle weakness - made me a bit sluggish climbing stairs.

hope that helps :)
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grandsons4
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Re: Vitamin K..how much?

Post by grandsons4 »

In case you haven't heard of her, I suggest googling Dr. Kate Rheaume-Bleue. She discusses the benefits of K2 (not really available from greens), the distinction from K1 on blood coagulation, the differences in the sub-types of K2 (MK4, MK7, etc.), and its association with calcium absorption and distribution.
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jimmylegs
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Re: Vitamin K..how much?

Post by jimmylegs »

yea true - diff vit ks but whfoods focuses on just the one. animal sources for the other if i'm not mistaken - cheese, butter, etc all the things i missed out on during the vegan yrs :S ugh
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NHE
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Re: Vitamin K..how much?

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MrChris wrote: Also, since i've read mixed review. Can Vitamin k2 induce blood clotting? I ask this because many sites say not to mix vitamin K with anticoagulants. However, they do not specify if its k1, 2 or 3 that they are talking about. From my readings it seems k1 will increase blood platelets
Warfarin and coumadin work by inhibiting vitamin k. With the regular INR monitoring, a measure of the time it takes the blood to clot, that's required with these drugs, the doctors will note the INR drop induced by taking vitamin k and just prescribe more warfarin or coumadin since a particular INR, usually around 2-3, is required for patients with atrial fibrillation for example. It's a vicious cycle. Vitamin k2 is critical for keeping calcium out of your arteries by activating matrix GLA protein. However, warfarin and coumadin don't discriminate between k1 and k2 and inhibit both. There was a series of papers that showed that quercetin can reverse warfarin induced calcification independent of matrix GLA and vitamin k.

Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
http://www.ncbi.nlm.nih.gov/pubmed/23117658

Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.
http://www.ncbi.nlm.nih.gov/pubmed/23223575

New therapeutic approaches to arterial calcification via inhibition of transglutaminase and β-catenin signaling.
http://www.ncbi.nlm.nih.gov/pubmed/24533936
MrChris
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Re: Vitamin K..how much?

Post by MrChris »

Fantastic. Thank you for all the responses. I ask because i have mild. carotid stenosis and wanted to make sure that taking MK7 wasnt going to cause a problem.
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jimmylegs
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Re: Vitamin K..how much?

Post by jimmylegs »

i ended up with severe magnesium depletion in spite of daily supplementation after long term high dose vit d3 (5000IU per day)

fyi
Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis.
http://www.researchgate.net/profile/Adr ... 000000.pdf

not sure what the significance of the hemodialysis aspect would be, but looks promising. make sure you're getting 300-400 mg of mag per day just for YOU, and then some more to pacify the oral D3 supplement. obviously emphasize nutrient-dense dietary sources as much as poss!
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NHE
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Re: Vitamin K..how much?

Post by NHE »

MrChris wrote:Fantastic. Thank you for all the responses. I ask because i have mild. carotid stenosis and wanted to make sure that taking MK7 wasnt going to cause a problem.
As long as you're not on warfarin or another vitamin K antagonist, I don't think taking K2 it will be a problem. By the way, you might also want to look into getting your homocysteine levels checked.

Plasma homocysteine levels and mortality in patients with coronary artery disease.
http://www.ncbi.nlm.nih.gov/pubmed/9227928
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