2016 abstract: MS brain volume loss with low serum vit A

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2016 abstract: MS brain volume loss with low serum vit A

Postby jimmylegs » Sat May 06, 2017 7:35 pm

Serum Retinol Levels are Associated with Brain Volume Loss in Patients with Multiple Sclerosis
http://journals.sagepub.com/doi/full/10 ... 6686261%20

Background: Brain atrophy has been recognised as an endpoint of irreversible tissue loss that is closely associated with disability in patient with multiple sclerosis (MS). Although predicting future brain volume loss is important, studies have been shown only few biomarkers that can predict brain volume loss (BVL).

Objective: The aim of this study is to elucidate the association between longitudinal BVL and serum biomarker candidates.

Methods: This single-centered retrospective observational study intended to cover MS patients during January, 2008 to March, 2016. Inclusion criteria were: 1) patients who have brain MRI two times with intervals of more than 24 months; 2) patients who have blood test at the time or within 3 months of MRI scan. Evaluation of brain volume was done using SIENAX and SIENA in the FMRIB software library (FSL). Three serum biomarker candidates, uric acid (UA), 25-hydroxybitamin D (25(OH)D) levels and retinol binding protein (RBP) levels were measured.

Results: Twenty-three patients with MS were included in this study. We found that serum RBP levels were significantly correlated with percentage brain volume change (PBVC) (p = 0.0079). Furthermore, best subset selection of multiple linear regression models identified baseline normalised brain volume (NBV) and serum RBP as the best predictors of PBVC (R^2 = 0.23, p = 0.027).

Conclusions: Our study shows that lower serum retinol levels are associated with greater longitudinal brain volume loss and that serum RBP and can be a predictor of brain volume loss.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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