2014 study: Vits A, D & E and altered MS inflammation

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2014 study: Vits A, D & E and altered MS inflammation

Postby jimmylegs » Fri Oct 27, 2017 6:45 am

Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis
https://journals-scholarsportal-info.pr ... mipwms.xml

"Our main findings are that
(i) rising 25(OH)D (vitamin D) levels are positively associated with IL-1Ra and sFRP3, but only before IFN-β treatment,
(ii) rising retinol (vitamin A) levels are negatively associated with PTX3 both before and during IFN-β treatment and
(iii) rising α-tocopherol (vitamin E) levels are positively associated with CXCL16 levels, but only during IFN-β treatment."

well doesn't this just remind me of the old days immediately post-dx... off to wikipedia ;)

https://en.wikipedia.org/wiki/Interleuk ... antagonist
... a natural inhibitor of the pro-inflammatory effect of IL1β

Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance

PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the mouse, < 2 ng/mL in humans), increase rapidly (peaking at 6–8 h after induction) and dramatically (200–800 ng/mL) during endotoxic shock, sepsis and other inflammatory and infectious conditions, correlating with the severity of the disease. Under these conditions, PTX3 is a rapid marker for primary local activation of innate immunity and inflammation

no time for CXCL16 atm, but suspect for now that increase = good.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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