2014 study: Dietary habits and serum selenium in RRMS

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2014 study: Dietary habits and serum selenium in RRMS

Postby jimmylegs » Tue Dec 05, 2017 6:16 am

eat yer brazil nuts, kids!

Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis
https://nutritionj.biomedcentral.com/tr ... entral.com

Background: Dietary habits and adequate dietary intake of antioxidants in the diet may be one of the most
important environmental factors for the prevention of Multiple Sclerosis (MS).
Objectives: The aim of this study was to estimate selenium (Se) concentration, glutathione peroxidase (GSH-Px)
activity and total antioxidant status (TAS) in the serum of patients with MS and the influence of dietary habits on
the status.

Methods: 101 patients with relapsing-remitting MS (aged 18-58 years), as well as control group of 63 healthy
people (aged 19-65 years) were studied. Food-frequency questionnaires were implemented to collect the dietary
data. Se concentration in the serum samples was determined by atomic absorption spectrometry. GSH-Px activity
and TAS in examined serum was measured using the ready-made sets of tests by Randox Laboratories Ltd., UK.
Results: Serum Se concentration and GSH-Px activity in the serum of patients with MS (55.2±16.2 μg/L,
6676.1±2386.4 U/L; respectively) were significantly decreased (p<0.01, p<0.05; respectively) compared with control
group (79.2±20.6 μg/L, 8029.9±2650.1 U/L; respectively).
A significant correlation (r=0.39, p<0.01) was observed
between Se concentration and GSH-Px activity in the serum of examined patients. TAS value in the serum of
patients with MS (1.03±0.37 mmol/L) was also significantly lower (p<0.01) than in healthy volunteers (1.48±0.41 mmol/L).
Frequent consumption of poultry, bakery products, pulses and fish seemed to increase serum Se concentration
in the group of patients; whereas frequent consumption of butter, wholegrain bread, sweet beverages and
sugar was found to accompany with lower values of Se in the serum. We have observed significant decrease TAS
(p<0.05, p<0.01; respectively) in the serum of smokers and those patients who received immunomodulatory
drugs (0.95±0.39 mmol/L, 0.92±0.34 mmol/L; respectively) compared with no-smoking patients and not taking
immunomodulators (1.14±0.33 mmol/L, 1.31±0.31 mmol/L; respectively).

Conclusions: Serum Se concentration, GSH-Px activity and TAS value were significantly lower in patients with
relapsing-remitting MS compared with healthy volunteers. Dietary habits have a significant influence on Se status.
Smoking cigarettes and intake of immunomodulatory drugs therapy have a negative impact on TAS of examined
patients.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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jimmylegs
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