2017: Iron, Zinc & Oxidative Status in Neuroinflammation

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2017: Iron, Zinc & Oxidative Status in Neuroinflammation

Postby jimmylegs » Mon Dec 11, 2017 7:38 pm

Chapter 5 – Chemical Elements and Oxidative Status in Neuroinflammation
https://www.sciencedirect.com/science/a ... 5626000051
"Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination and neurodegeneration. It is believed to be caused by the interaction between genetic susceptibility and environmental factors.

Evidence from several epidemiological and clinical studies suggested that changes in metal levels and oxidative status may contribute to the development of various neurological diseases, including MS. Many studies have been conducted to evaluate the mechanisms by which the metals induce neuroinflammation and neurotoxicity. Here, we review the literature regarding the role of metals with supposed pathogenic relevance in MS.

We also discuss the results of our previous studies showing chemical elements and oxidative status imbalance in the serum of patients with MS and other neurodegenerative diseases, as well as in people with clinically isolated syndrome (CIS, considered an early phase of MS).

Descriptive statistics revealed numerous differences between each disease and healthy status. A concordant imbalance (reduction in Fe, Zn, and serum antioxidant capacity, and increase in serum oxidative status) was shared by Alzheimer’s disease, Parkinson’s disease, and MS. The peculiar imbalance in serum elements and oxidative status that characterizes CIS people may predict conversion to clinically definite MS."

i like how they specified healthy vs normal. will be interesting to get into the full text on this one.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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