Inhibition of Histamine Response by Zinc

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Inhibition of Histamine Response by Zinc

Postby jimmylegs » Sat Feb 17, 2018 3:48 pm

Inhibition of Histamine Response by Zinc
https://www.karger.com/Article/Abstract/135963

"Zinc cream has been used for many years in the treatment of skin conditions and allergy. In modern times it has been replaced by cortisone and antihistamine. Zinc has also recently been advised in cases of malnutrition, where zinc levels are low, to aid wound healing.
In this paper we have investigated the effect of zinc on histamine and SRS responses as histamine and SRS play a part in allergy (Kellaway and Trethewie, 1940) and histamine and zinc stimulate healing in wounds."

can't get full text :( it is just guinea pigs though...

not a rich vein of research out there using "serum histamine" and "serum zinc"
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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Re: Inhibition of Histamine Response by Zinc

Postby jimmylegs » Sat Feb 17, 2018 4:15 pm

kind of thing that *is* available

Association between itching and the serum zinc levels in patients with varicose veins
fft: https://www-ncbi-nlm-nih-gov.proxy.lib. ... MC5609042/

"The zinc content was significantly lower in the patients with itching (72.5 ± 7.1 μg/dL) compared to that in the control group (79.1 ± 8.1 μg/dL) (p < 0.05)"

ire 11.1 umol/L vs 12.1 umol/L ie deficient vs nearly so

https://www-ncbi-nlm-nih-gov.proxy.lib. ... gure/Fig3/

sadly, histamine only comes into it in the references.

12. Sanada S, Kuze M, Yoshida O. Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels. Hinyokika Kiyo. 1987
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 11169
Joined: Sat Mar 11, 2006 4:00 pm

Re: Inhibition of Histamine Response by Zinc

Postby jimmylegs » Sat Feb 17, 2018 4:52 pm

Serum zinc concentrations in patients on maintenance hemodialysis and its relationship with anemia, parathyroid hormone concentrations and pruritus severity
fft: http://www.sjkdt.org/article.asp?issn=1 ... -Khavidaki

Some authors proposed Zn deficiency as a possible cause of histamine release and the de­velopment of uremic pruritus in HD patients...

...Control group included healthy volunteers who were matched in age and sex with the case group and did not use any supplementary Zn products or were not on severe weight reducing diet...

...The mean serum Zn concentration in patients on maintenance HD was significantly lower than that of the control group (69.16 ± 17.29 μg/dL vs 82.93 ± 14.75 μ/dL; P= 0.001); how­ever, it was not different with the cut-off point of 70 μ/dL that is recommended by Gibson [7] (P= 0.66)....

...we did not find any correlation bet­ween serum Zn concentration of the patient and their pruritus severity, a Japanese study suggests that Zn deficiency may participate in increase histamine level in HD patients and result in the development of uremic pruritus. Oral Zn sulfate supplementation relieved pru­ritus in 53% of their patients. They explained this finding with the inhibitory effect of Zn on various functions of some cells including mast cells.

so 10.6 umol/L vs 12.7 umol/L

again, deficient vs nearly so. would rather they'd actually measured histamine than pruritis severity.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 11169
Joined: Sat Mar 11, 2006 4:00 pm


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