2018 study: Serum mag inversely associated w EBV viral load

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2018 study: Serum mag inversely associated w EBV viral load

Postby jimmylegs » Wed Mar 07, 2018 9:36 am

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda
https://www.sciencedirect.com/science/a ... 2117302035

Abstract
Background
Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda.

Methods
Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors.

Results
Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration.

Interpretation
Plasma Mg2+ deficiency is associated with high EBV levels and eBL.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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Re: 2018 study: Serum mag inversely associated w EBV viral l

Postby jimmylegs » Thu Mar 08, 2018 6:58 am

a bit more detail...

Plasma Mg2+ levels were measured in a random sample of 45 Ugandan women with the sickle cell trait: 25 with high (upper-quartile) peripheral blood EBV viral load and 20 with low (lower-quartile) EBV viral load

Plasma Mg2+ levels were significantly decreased (p = 0.014) in women with high in comparison to women with low EBV viral load in peripheral blood (1.73 vs 1.87 mg/dl

aka 0.71 mmol/L vs 0.77 mmol/L; both very low normal

Plasma Mg2+ levels in the children with eBL were significantly decreased in comparison with those in the healthy children (p = 0.0016), and the mean plasma Mg2+ level for eBL patients was consistent with mild Mg2+ deficiency (1.81 versus 1.95 mg/dl, Fig. 1B).

0.74 vs 0.80 mmol/L

'healthy' as in 'without burkett's lymphoma'? will have to dig in again for that detail... either way - again levels far too low to exclude mag deficiency in both groups
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 11234
Joined: Sat Mar 11, 2006 4:00 pm


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