2018 review: vitamins & MS incidence,progression,improvement

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2018 review: vitamins & MS incidence,progression,improvement

Postby jimmylegs » Sun Jun 17, 2018 6:30 am

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis
https://www.sciencedirect.com/science/a ... 0218300078

Highlights
•Vitamin D has important roles in MS and can be measured as precursor, or used as treatment.
•B6, B9, and B12 deficiency can elevate serum level of homocysteine, which may lead to an inflammatory state in the CNS.
•Vitamins A, E, and B1 deficiencies are believed to play important roles in MS pathophysiology according to animal models.
•Using high doses of vitamin C can worsen MS conditions because of promoting Fenton reaction.
•Vitamins D, B9, B12, A, B1, and B3 may improve relapses, degeneration rate, inflammation, and clinical symptoms.

Abstract
Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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Re: 2018 review: vitamins & MS incidence,progression,improve

Postby NHE » Mon Jun 18, 2018 3:24 am

Note that the full text for this article is freely available.
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Re: 2018 review: vitamins & MS incidence,progression,improve

Postby Zyklon » Mon Jun 18, 2018 10:10 am

Great article. I am interested about remyelination effects of vitamins.

Gonna read this:

M. Goudarzvand, M. Javan, J. Mirnajafi-Zadeh, et al.
Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide
Cell. Mol. Neurobiol., 30 (2010), pp. 289-299, 10.1007/s10571-009-9451-x
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Re: 2018 review: vitamins & MS incidence,progression,improve

Postby NHE » Tue Jun 19, 2018 2:09 am

Zyklon wrote:Great article. I am interested about remyelination effects of vitamins.

Gonna read this:

M. Goudarzvand, M. Javan, J. Mirnajafi-Zadeh, et al.
Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide
Cell. Mol. Neurobiol., 30 (2010), pp. 289-299, 10.1007/s10571-009-9451-x

https://www.ncbi.nlm.nih.gov/pubmed/19768531

Unfortunately, the abstract doesn't indicate what type of vitamin E was used.
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Re: 2018 review: vitamins & MS incidence,progression,improve

Postby jimmylegs » Tue Jun 19, 2018 3:24 pm

nor in full text via research gate. product info pretty vague. company catalogue:
https://www.dsm.com/content/dam/dsm/anh ... 015-16.pdf
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
User avatar
jimmylegs
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Posts: 11555
Joined: Sat Mar 11, 2006 4:00 pm


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