Lipoic acid inhibits B cell migration across BBB in RRMS

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Lipoic acid inhibits B cell migration across BBB in RRMS

Postby NHE » Sun Sep 02, 2018 1:03 am

Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis.
J Neuroimmunol. 2018 Feb 15;315:24-27.

    Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.
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Re: Lipoic acid inhibits B cell migration across BBB in RRMS

Postby Petr75 » Mon Sep 03, 2018 9:09 am

2010 Feb 11
Pharmacokinetic study of lipoic acid in multiple sclerosis: Comparing mice and human pharmacokinetic parameters
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489916/

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2015 Nov 11
Lipoic Acid Reduces Inflammation in a Mouse Focal Cortical EAE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664888/

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18/04/16
Lipoic acid may provide 'inexpensive' MS treatment
https://www.ms-uk.org/apr18

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ECTRIMS2016 – Antioxidant Lipoic Acid Appears to Slow SPMS Patients’ Neurodegeneration
https://multiplesclerosisnewstoday.com/ ... generation

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03.07.2017
Lipoic acid outperformed ocrelizumab
https://www.medicalnewstoday.com/articles/318225.php

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2018 Jul
Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects
https://www.ncbi.nlm.nih.gov/pubmed/29143287

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https://ereska.net/viewtopic.php?f=17&t=237&start=60
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