2017 correspondence: Don't discount all curcumin trial data

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2017 correspondence: Don't discount all curcumin trial data

Postby jimmylegs » Sun Oct 07, 2018 10:39 am

Don't discount all curcumin trial data (2017)
https://www.nature.com/articles/543040c

We (royal we it's one guy) argue that the clinical potential of the spice extract curcumin should not be dismissed simply on the grounds that it yields confusing results in molecular drug screens (Nature 541, 144–145; 2017; see also K. M. Nelson et al. J. Med. Chem. http://doi.org/bw46; 2017).

Nelson and colleagues claim a lack of evidence for curcumin's therapeutic benefits “despite thousands of research papers and more than 120 clinical trials” (www.clinicaltrials.gov). However, a PubMed search under 'curcumin double-blind placebo-controlled clinical trial' yields 49 entries, of which 17 recent trials show efficacy. In addition, there are 27 other clinical trials and at least 5 animal studies of curcumin that point to therapeutic benefits (see full reference list in Supplementary information).

The assumption that a drug candidate must have a single known target and compatibility with high-throughput screening to enter the clinic can preclude promising drug candidates (R. L. Elliott Am. Chem. Soc. Med. Chem. Lett. 3, 688–690; 2012). Current detection methods for target engagement cannot gauge the full pharmacological spectrum of an investigational drug, so should be used with other screening paradigms. Also, the binding behaviour of curcumin to multiple molecular targets is associated with modulation rather than outright inhibition. And high-throughput screening is prone to technical artefacts that can make it a deceptive arbiter for excluding potential drugs.

In light of these considerations, curcumin's molecular targets and their regulatory mechanisms warrant further investigation if we are to build on the promising results that are already to hand in humans and animals.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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Re: 2017 correspondence: Don't discount all curcumin trial d

Postby ElliotB » Sun Oct 07, 2018 12:27 pm

I have been taking Curcumin for several years and like every other supplement I take, I have no idea whether it is helping or not. I can only hope that it and the others I take are indeed having a positive effect, who knows...

I think unlike many drugs where the desired outcome often occurs quickly and is obvious (if it is working), natural supplements often take much much longer to work (if they work at all). I don't think typically there is any way of knowing, and a leap of faith is required (crossing your fingers may also be beneficial).

The dietary supplement industry is largely unregulated, so the companies offering supplements can make unsubstantiated claims and you really never know for sure if you are getting the product purchased as detailed on the package - such a deal!
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Re: 2017 correspondence: Don't discount all curcumin trial d

Postby NHE » Sun Oct 07, 2018 11:21 pm

ElliotB wrote:I have been taking Curcumin for several years and like every other supplement I take, I have no idea whether it is helping or not. I can only hope that it and the others I take are indeed having a positive effect, who knows...

A regular 95% curcumin extract is poorly absorbed. The solution is to either consume whole turmeric or take an absorption enhanced curcumin extract such as BCM-95 or Longvida for example.

Read more about Longvida. https://vs-corp.com/longvida/

I would take 1 tablespoon of whole turmeric and mix it with some olive oil to make a slurry, let it sit for a few minutes and then add some plain yogurt to make it more palatable.
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