Enhanced absorption curcumin improves memory

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Enhanced absorption curcumin improves memory

Postby NHE » Thu Nov 08, 2018 5:56 am

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.
Am J Geriatr Psychiatry. 2018 Mar;26(3):266-277.

    OBJECTIVE: Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET).

    METHODS: Forty subjects (age 51-84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months. Primary outcomes were verbal (Buschke Selective Reminding Test [SRT]) and visual (Brief Visual Memory Test-Revised [BVMT-R]) memory, and attention (Trail Making A) was a secondary outcome. FDDNP-PET signals (15 curcumin, 15 placebo) were determined in amygdala, hypothalamus, medial and lateral temporal, posterior cingulate, parietal, frontal, and motor (reference) regions. Mixed effects general linear models controlling for age and education, and effect sizes (ES; Cohen's d) were estimated.

    RESULTS: SRT Consistent Long-Term Retrieval improved with curcumin (ES = 0.63, p = 0.002) but not with placebo (ES = 0.06, p = 0.8; between-group: ES = 0.68, p = 0.05). Curcumin also improved SRT Total (ES = 0.53, p = 0.002), visual memory (BVMT-R Recall: ES = 0.50, p = 0.01; BVMT-R Delay: ES = 0.51, p = 0.006), and attention (ES = 0.96, p < 0.0001) compared with placebo (ES = 0.28, p = 0.1; between-group: ES = 0.67, p = 0.04). FDDNP binding decreased significantly in the amygdala with curcumin (ES = -0.41, p = 0.04) compared with placebo (ES = 0.08, p = 0.6; between-group: ES = 0.48, p = 0.07). In the hypothalamus, FDDNP binding did not change with curcumin (ES = -0.30, p = 0.2), but increased with placebo (ES = 0.26, p = 0.05; between-group: ES = 0.55, p = 0.02).

    CONCLUSIONS: Daily oral Theracurmin may lead to improved memory and attention in non-demented adults. The FDDNP-PET findings suggest that symptom benefits are associated with decreases in amyloid and tau accumulation in brain regions modulating mood and memory.

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Theracurmin is a BCM-95 formulation which is better absorbed than plain curcumin and some other forms. There are many sources for BCM-95, some are discussed in the following topic. natural-approach-f27/topic18585.html

There is also Longvida cucumin which may be even better absorbed. https://www.vitacost.com/now-curcubrain ... g-capsules

Read more about Longvida. https://vs-corp.com/longvida/
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NHE
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Re: Enhanced absorption curcumin improves memory

Postby ElliotB » Thu Nov 08, 2018 6:27 am

This is an interesting formulation:

https://www.purityproducts.com/brain-he ... cmp=search



Another excellent supplement for brain health is Phosphatidylserine (PS), considered by many to be an essential brain nutrient. Here is a link to an excellent article about it along with reviews of numerous trials:

https://www.lifeextension.com/magazine/ ... ps/Page-01
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