I’m happy to report that I think it’s finally time to start a progesterone thread.
I know the confidence level in mouse research (mine included) ranges from 0 to –0, but I wanted to initiate a timeline of the development of progesterone starting with the early research in mice. And, the mouse trials are off and running…..
Here’s some postive info (for the mice at least) and the studies have been on the traditional (EAE) and non-traditional (not auto-immune) animal models.
Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis (auto-immune EAE model)
Clinically, PROG produced a moderate delay of disease onset and reduced the clinical scores. Thus, PROG attenuated disease severity, and reduced the inflammatory response and the occurrence of demyelination in the spinal cord during the acute phase of EAE
I found the second study (from Ectrims 2007) even more interesting because it appears to be based on a “not auto-immune” perspective of MS. It’s based on a mouse model that takes into account the research findings of Prineas and Barnett (oligodendrocytes die first).
Estrogen and progesterone treatment prevents cuprizone-induced demyelination
Barnett and Prineas (Ann Neurol 2004, 55:458) described extensive oligodendrocyte apoptosis and microglia activation in myelinated tissues of young MS patients with relapsing and remitting MS revealing no or few invading lymphocytes.
These data clearly indicate that both sex hormones are required to fully prevent cuprizone-induced demyelination in the CC. We conclude that P and E supplementation of MS patients may represent a valuable clinical tool.
Guys—note that this was a study in male mice and both progesterone and estrogen were found to “represent” a potentially valuable clinical tool.
Let’s hope clinical trials don’t take forever…I of course assume it will make it that far. The countdown begins.....
Since the Phase II Clinical Trial of progesterone in traumatic brain injury was positive I do have some confidence the mice research might actually translate to humans.
Take care all