Good question. I don't know about aspirin's influence on CCSVI, but it has been successfully tested to see if it helps MS patients with fatigue.
A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis.
Neurology. 2005 Apr 12;64(7):1267-9.
Wingerchuk DM, Benarroch EE, O'Brien PC, Keegan BM, Lucchinetti CF, Noseworthy JH, Weinshenker BG, Rodriguez M.
Department of Neurology Mayo Clinic, Scottsdale, AZ 85259, USA. firstname.lastname@example.org
Comment in: Neurology. 2005 Apr 12;64(7):1111-2.
Pharmacotherapeutic options for multiple sclerosis (MS)-related fatigue are limited. Thirty patients were randomly assigned to aspirin (ASA) 1,300 mg/day or placebo in a double-blind crossover study. Results favored ASA for the main clinical outcomes: Modified Fatigue Impact Scale scores (p = 0.043) and treatment preference (p = 0.012). There were no significant adverse effects. The results warrant further study and support a role for ASA-influenced mechanisms, perhaps immunologic, in the generation of MS-related chronic fatigue.