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OCB negative MS - immunogenetically distinct

Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct

http://n.neurology.org/content/67/6/106 ... ticle-info

Abstract

We sought to determine whether Swedish patients with multiple sclerosis (MS) with and without oligoclonal bands (OCBs) in the CSF constitute distinct subpopulations, clinically and immunogenetically. Our findings indicate that OCB-negative MS shares the same clinical features as OCB-positive MS regarding female predominance, age at onset, proportion of primary progressive cases, rate of ...
Read more : OCB negative MS - immunogenetically distinct | Views : 37 | Replies : 0 | Forum : MS Etiology and Pathogenesis


Dysregulated EBV infection in MS. Old but relevant.

They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

http://jem.rupress.org/content/204/12/2899?papetoc=

Abstract

Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS), but direct proof of its involvement in the disease is still missing. To test the idea that ...




Biomarkers: Response to Glatiramer Acetate predictable

It seems that a biomarker in blood predicts response to GA

Image

Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis

https://www.sciencedirect.com/science/a ... 0018302314

Highlights

• We investigated the role of p-SIRT1 and H3K9me3 as biomarkers in multiple sclerosis.
• P-SIRT1 was found to be a biomarker of disease activity.
• H3K9me3 was also found to be a biomarker of clinical ...


2014 case rpt:Optic Neuropathy, Demyelination in Hyperemesis

interesting:

Simultaneous Optic Neuropathy and Osmotic Demyelinating Syndrome in Hyperemesis Gravidarum (2014)
https://www.amjmedsci.com/article/S0002 ... 6/abstract

pastable portion of first paragraph:
"A 16-year-old African American girl at the 20th week of pregnancy presented with blurry vision. She had been having nausea and vomiting requiring home intravenous ondansetron. She could tolerate only liquids and had lost 30 pounds (approximately 25% of body weight) over the course of pregnancy. On the day ...
Read more : 2014 case rpt:Optic Neuropathy, Demyelination in Hyperemesis | Views : 98 | Replies : 0 | Forum : Natural Approach


Neuro symptoms MRI on Tuesday

I will try to be brief.
The most prominent symptom for me has been EXTREME fatigue. Probably for at least a year. It does come and go though. For a couple of months it will be debilitating. Then it will ease up and I'll feel relatively alright.
Other symptoms: Tripping over virtually nothing, terrible balance and spatial awareness (always bumping into things), constantly dropping things, itchy spells when I'm going through a period of fatigue, ...
Read more : Neuro symptoms MRI on Tuesday | Views : 260 | Replies : 4 | Forum : Undiagnosed


How many have noticed results on twice daily dosing?

Just wondering. Dont really notice anything with daily dosing at night, wondering if anyone has benefitted from twice daily.

I weigh 65kgs and usually take 4mg.

Thanks,
Read more : How many have noticed results on twice daily dosing? | Views : 263 | Replies : 0 | Forum : Low Dose Naltrexone


PM10

May 2018
METIS Department, EHESP French School of Public Health, Rennes, France ..
Ozone, NO2 and PM10 are associated with the occurrence of multiple sclerosis relapses. Evidence from seasonal multi-pollutant analyses
https://www.sciencedirect.com/science/a ... 5118300422

Highlights
•Season-dependent associations between short term exposure to NO2 and O3 and risk of MS relapses were observed.
•Confirmation of PM10-associated risk of MS relapses.
•A multi-pollutant approach should be systematically intended, especially when assessing ...
Read more : PM10 | Views : 284 | Replies : 1 | Forum : General Discussion


Multiple Sclerosis: an "EMotional" issue. The microbian code

This is an excerpt from my last page posted in my blog about MS as an emotional issue (not only but above)…that I would like to share with you.

It is curious to observe the inverse way that I have followed in my long way to healing where we inmerse in, going in my case from physical to non-physical factors. So I started with CAM therapies with something so physical and elementary as exercise and ...


Joint and Muscle pain while on the Vitamin D Protocol

Hi to all on the Vitamin D Protocol,

I started the protocol 3-8-18 just 4 months ago. But the second month in, I started having much joint and muscle pain in mostly my legs and lower back. I've read other patients comments about this but not how long this pain lasts. My pain is not lessening and it's been 2 months since it started. My Dr. did recommend a different formulation which I will try ...


 

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