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simvastatin mechanism is independent from cholesterol

Whatever simvastatin does in MS is independent from its cholesterol function

Abstract

https://www.biorxiv.org/content/early/2018/06/11/343442

The analysis of clinical trials is limited to pre-specified outcomes, thereby precluding a mechanistic understanding of the treatment response.

Multivariate mechanistic models can elucidate the causal chain of events by simultaneous analysis of multi-modal data that link intermediate variables to outcomes of interest. A double-blind, randomised, controlled, phase 2 clinical trial in secondary progressive multiple sclerosis ...


Having scary symptoms, could it be B12/Folate deficiency?

Hi everybody,

I am new to the forum but have been coming here for some weeks to read posts, hoping to find an answer to my health problems. I finally decided to register and ask for help. I know that nobody can diagnose me with MS or any other disease through an online thread but I am hoping others with experience/knowledge can shed some light on my symptoms.

First, I would like to introduced myself. ...
Read more : Having scary symptoms, could it be B12/Folate deficiency? | Views : 81 | Replies : 5 | Forum : Undiagnosed


The heat!!!

Hi all I'm looking for opinions or suggestions. I'm feeling fairly well with my MS I was diagnosed 10 1/2 years ago. But what is really basically paralyzing me is the sun. I'm in Canada so it's just getting hot here now but a few minutes in the sun and I can hardly walk. I've thought about CCSVI but when I convince myself to go ahead with that then I read something bad about the ...
Read more : The heat!!! | Views : 101 | Replies : 2 | Forum : General Discussion


2018 review: vitamins & MS incidence,progression,improvement

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis
https://www.sciencedirect.com/science/a ... 0218300078

Highlights
•Vitamin D has important roles in MS and can be measured as precursor, or used as treatment.
•B6, B9, and B12 deficiency can elevate serum level of homocysteine, which may lead to an inflammatory state in the CNS.
•Vitamins A, E, and B1 deficiencies are believed to play important roles ...
Read more : 2018 review: vitamins & MS incidence,progression,improvement | Views : 101 | Replies : 2 | Forum : Natural Approach


Multiple Sclerosis Desatascador

I will post here only how to obtain such. Its uses will be publicized separately.

Buy from that internet distributor that begins with the first letter of the alphabet and shares its name with a large South American river a personal travel fan that runs on 2 AA batteries. I can't publicize its name here for obvious reasons. It goes under at least two trade names. It looks like an electric toothbrush with a flower ...
Read more : Multiple Sclerosis Desatascador | Views : 182 | Replies : 4 | Forum : General Discussion


Sugar Babies

US toddlers aged 19-23 months consume 7.1 teaspoons of added sugar per day.

Consumption of added sugars among U.S. infants aged 6-23 months, 2011-2014
https://www.eventscribe.com/2018/Nutrit ... nID=405508

Keep the kids out of McDonaldland! Ketchup is not a health food. It's 24% sugar.
Read more : Sugar Babies | Views : 190 | Replies : 0 | Forum : Diet


Tysabri and sunburn?

I don't spend much time outdoors. An hour or so at lunchtime spent jogging is about it. So why do I have a rather deep tan and constant peeling sunburn?

TIA,

kevin
Read more : Tysabri and sunburn? | Views : 198 | Replies : 5 | Forum : General Discussion


2018 study: Nutritional Intake Correlates w Function in PwMS

Nutritional Intake Correlates with Function in Persons with Mild-to-Moderate Multiple Sclerosis (2018)
http://www.ijmsc.org/doi/abs/10.7224/15 ... =cmsc-site

Abstract
Background: To assess the association between nutrition, ambulation, daily activity, quality of life (QOL) and fatigue in individuals with mild-to-moderate disability with multiple sclerosis (MS).

Methods: Cross-sectional pilot study that included twenty ambulatory volunteers with MS (14 F/6 M, 57.9±10.2 years, EDSS = 4.1±1.8). Primary outcome variables included dietary assessment (3-day dietary consumption ...
Read more : 2018 study: Nutritional Intake Correlates w Function in PwMS | Views : 223 | Replies : 4 | Forum : Diet


Frozen fruits and vegetables=less pesticide

Frozen fruits and vegetables generally have less pesticide residue than fresh conventional produce.

And nutrition levels are about the same as fresh.

Why is this so? How is this possible?

Fresh fruits and vegetables are picked before they are ready to eat (applies obviously mainly to fruits) and all are basically heavily treated with pesticides after they are harvested to help preserve them during the time it takes to get from the farm to ...
Read more : Frozen fruits and vegetables=less pesticide | Views : 213 | Replies : 0 | Forum : General Discussion


Biomarkers: CIS to MS conversion

Identification of candidate biomarkers in converting and non-converting clinically isolated syndrome by proteomics analysis of cerebrospinal fluid

https://link.springer.com/article/10.10 ... 018-0954-4

Abstract

Multiple sclerosis (MS) often starts in the form of clinically isolated syndrome (CIS) and only some of the CIS patients progress to relapsing-remitting MS (RRMS). Biomarkers to predict conversion from CIS to MS are thus greatly needed for making correct treatment decisions.

To identify a predictive cerebrospinal fluid ...
Read more : Biomarkers: CIS to MS conversion | Views : 229 | Replies : 0 | Forum : MS Etiology and Pathogenesis


 

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