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Angiogenesis, fingolimod and ceramides

Recently I am finding some connections that I would like to share.

First of all, Fingolimod is a known active principle, an immune-modulator, which works theoretically modifying the behaviour of the Sphingosine-1-phosphate lipids, and in turn, the behaviour of b-cells and T-cells. But its action could be more than that.

The interesting connection is that Sphingosine-1-phosphate also modulates the Angiogenesis. Therefore a disregulated sphingosine system is expected to produce an unexpectedly wrong vascular system ( ...


Biomarkers. MS signature found in CSF

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

https://www.nature.com/articles/s41598-018-21497-5

Abstract

Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in heterogeneous clinical presentation. A very active MuS research field concerns the discovery of biomarkers helpful to make an early and definite diagnosis.

The sphingomyelin pathway has emerged as a molecular mechanism involved in MuS, since high levels of ceramides in cerebrospinal ...
Read more : Biomarkers. MS signature found in CSF | Views : 21 | Replies : 0 | Forum : MS Etiology and Pathogenesis


New award-winning documentary about MS now available.

I wanted to let everyone know that the new award-winning documentary about MS, "Living Proof", is now available at www.seelivingproof.com.

"Living Proof" sold out theatres in Canada and the USA. The documentary exposes the potential conflict of interest between pharmaceutical companies, neurologists and MS charities.

Here is the trailer:

https://www.youtube.com/watch?v=fjwSz2xsD1s&t=10s

Please do not hesitate to contact me with any questions or concerns.

Respectfully, ...
Read more : New award-winning documentary about MS now available. | Views : 38 | Replies : 0 | Forum : General Discussion


Lipoic Acid & Elevated Liver Enzymes: Anyone Else?

Hi everyone,
Kira here. I’m going to share my experience on this and ask if anyone else has experienced the same?

I started taking 1200 mg. Lipoic Acid in December when my neurologist recommended it, after he mentioned promising research results for MS.

I looked at the Clinical Trial being done at OHSU w/the VA in Portland, OR, using LA for MS, and after looking at the Adverse Events sections of that trial, asked my ...
Read more : Lipoic Acid & Elevated Liver Enzymes: Anyone Else? | Views : 20 | Replies : 1 | Forum : Natural Approach


Dr. Ebers' disturbing interview about MS drugs and FDA

Below is an important scene from the recent award-winning documentary about MS, "Living Proof". I suggest that anyone with MS watch this. Dr. George Ebers is one of the world's top MS researchers:

https://www.youtube.com/watch?v=i0m_isndqc0&t=12s

The entire documentary can be found at seelivingproof.com

Thanks,
Mathew
Read more : Dr. Ebers' disturbing interview about MS drugs and FDA | Views : 55 | Replies : 1 | Forum : General Discussion


Biomarkers. Response to Fingolimod can be predicted.

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

https://onlinelibrary.wiley.com/doi/abs ... /cns.12851

Summary

Fingolimod, an orally active immunomodulatory drug for relapsing‐remitting multiple sclerosis (RRMS), sequesters T cells in lymph nodes through functional antagonism of the sphingosine‐1‐phosphate receptor, reducing the number of potential autoreactive cells that migrate to the central nervous system. However, not all RRMS patients respond to this therapy. Our aim was to test the hypothesis that ...


PPMS: Two different subtypes set appart by fluid biomarkers

Transcriptional profiling of Primary Progressive Multiple Sclerosis patients identifies Fast and Slow progression patterns (P1.321)


http://n.neurology.org/content/90/15_Supplement/P1.321

Abstract

Objective: To investigate peripheral blood molecular pathways that operate in primary progressive multiple sclerosis (PPMS) and to identify transcriptional patterns associated with fast and slow disability progression

Design/Methods: The transcriptional profiling of peripheral blood mononuclear cells (PBMCs) obtained from 22 PPMS patients using Affymetrix Inc. technology was performed in comparison to ...


Psoriasis?

I was diagnosed with MS ten months ago and put on tysabri. No relapses since the original event. But I've got a scaly spot on the 4th finger of both hands. It's on the lateral side of the second knuckles. I know psoriasis is autoimmune like MS. Could these spots be related to MS?
Read more : Psoriasis? | Views : 142 | Replies : 2 | Forum : General Discussion






 

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