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A board to discuss the soon-to-be released drug Campath as a treatment for Multiple Sclerosis

Phase 2 complete....results in NEJM

improvements on disability scale in campath group, reduced lesions, better brain volume, no diff. between 12 or 24 mg doses....looks alot better than interferon-


Results Alemtuzumab significantly reduced the rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. 26.2%; hazard ratio, 0.29; 95% confidence interval , 0.16 to 0.54; P<0.001) and the annualized rate of relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P<0.001). The mean disability ...
Read more : Phase 2 complete....results in NEJM | Views : 2287 | Replies : 10


Clear and consise explanation

I know most has been cover over and over, but I found the following, and it seems to cover most points regarding Campath's method of action, in a clear and concise mannor. Its not for MS specifically, but its the same compound being used.
Alemtuzumab
Pharmacology and use:

Campath is used to treat leukemia by exploiting antibody mediated lysis of CD52 presenting cells. The CD52 antigen is a cell surface protein found on essentially all ...
Read more : Clear and consise explanation | Views : 1633 | Replies : 2


Campath research

The Accelerated Cure Project has produced a note on last week's ECTRIMS / ACTRIMS / LACTRIMS MS research conference. Here is the section from the note on Campath (Alemtuzamab).

Satellite Symposium -- Researching the Potential for a New
Treatment Paradigm: Alemtuzumab in MS (Sponsored by Bayer HealthCare and Genzyme) *** (Hollie)


At last year's ECTRIMS, there was a lot of exciting data about
alemtuzumab (Campath). Phase 3 studies are now underway so this was
more ...
Read more : Campath research | Views : 2139 | Replies : 2


6 months after Campath

Today was me & Jessica's 6 month check up. I scored 100% on the PASAT math test, and my vision is still awesome at 20/20 & 20/15.
This is the same as before Campath.
For the other neuro/reflexes, walking, and balance tests, I also scored about the same as before, my EDSS is 2.5
My left side is definately weaker as it always has been.

The EDSS might end up a little higher because I ...
Read more : 6 months after Campath | Views : 2467 | Replies : 3


Long term outcome of ITP and Graves

I had yet to personally read if the two major side effects discussed were long term or temporary, until I came across the following, so I thought I would store it somewhere:
http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=1307
He said the clinical trial so far has yielded five other cases of the bleeding disorder, called immune thrombocytopenic purpura , or ITP. All of those patients were treated and recovered.
So ITP appears to be a treatable condition?
...and two people developed ...
Read more : Long term outcome of ITP and Graves | Views : 1536 | Replies : 0


Five month update, shamless self promotion, and a question?

Well yesterday marked the five month date of my first Campath infusion. I wish I had more to report about how I feel, but it changes from day to day. I definitely feel the long term effects of the treatment. My hair has not recovered from the infusion. It used to be very healthy and shiny where as now it is dry and dull. My skin was never quiet the same. I am always dehydrated, ...
Read more : Five month update, shamless self promotion, and a question? | Views : 2474 | Replies : 5


A few days after the last infusion

It's been 4 days since the last campath infusion and I am sitting at home taking it easy. The weekend was kind of lousy since I felt like I had no energy. After the last infusion I felt fine but my energy levels quickly went downhill from there. A bunch of my old symptoms came back as well and it was hard to even walk upstairs at home. Needless to say I wasn't real happy ...
Read more : A few days after the last infusion | Views : 1891 | Replies : 5


Campath - Final day

My final infusion is complete and I just got back home from the doctors office. Everything seems fine...just as it has all week. Looking back over the week I think the most difficult part was sitting in the office for the six hours each day trying to figure out how to pass the time. The staff at the office was awesome so I was as comfortable as I could have been for the infusions. No ...
Read more : Campath - Final day | Views : 1362 | Replies : 0


I can run!

It may seem like a funny thing to get excited about but I haven't been able to run since 2002-3. At times a slow shuffle was the best I could manage.

Recovering enough to be able to run again always seemed to be out of reach.

Today I got caught in a sharp, heavy rain shower. Without thinking about it I just took off for cover. It was only when I was out of the ...
Read more : I can run! | Views : 8298 | Replies : 26




 

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