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A board to discuss the soon-to-be released drug Campath as a treatment for Multiple Sclerosis


Campath update

From Genzyme's financial results yesterday...



Genzyme and Schering AG Germany await comments from the FDA, following which they hope to resume dosing soon in the Phase 2 clinical trial evaluating Campath for the treatment of multiple sclerosis. The companies submitted a risk-management plan to the FDA and the EMEA earlier this month, which was approved by the study's Data Safety Monitoring Board. Results from a pre-planned interim analysis of the Phase 2 trial were highly ...
Read more : Campath update | Views : 2224 | Replies : 0


Campath info 1.12

Schering shares fall on FDA alert - bad news for Campath 01 December 2005
FRANKFURT (Reuters) - Shares in German drugmaker Schering fell as much as 1.1 percent on Thursday after U.S. regulators issued a health alert over its Campath drug in a trial to treat multiple sclerosis.

Campath is approved to treat a type of blood cancer, but in a study on multiple sclerosis, three patients developed a severe blood disorder and one of ...
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Campath info

Some Campath data from Pubmed...



The window of therapeutic opportunity in multiple sclerosis Evidence from monoclonal antibody therapy.

J Neurol. 2005 Jul 27;

Coles AJ, Cox A, Le Page E, Jones J, Trip SA, Deans J, Seaman S, Miller DH, Hale G, Waldmann H, Compston DA.
Department of Clinical Neurosciences, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, ajc1020@medschl.cam.ac.uk.

From 1991-2002, we treated 58 patients with ...
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3 months in

I went for my 3 month checkup today. Unfortunately I didn't get a neurological assesment but it would only have confirmed what I know. Since treatment my condition has definitely improved. Prior to treatment I was assesed as EDSS 4.0, in my own judgement I have improved by at least 1 EDSS point since treatment, probably more. Hopefully these improvements will continue.

A sobering note to the proceedings was that one patient on the CAMMS223 ...
Read more : 3 months in | Views : 3810 | Replies : 8


April check up

Hi all,

I had my quarterly appointment for the study yesterday and things went well, though I only dropped to a 1.0 on the EDSS scale. I was hoping for 0.0, but I guess that might be a tad hopeful. Apparently I’m missing some reflex actions in my left foot, and according to the NP it’s unlikely that I’ll ever get them back. Not a big deal as it’s not noticeable unless I get frustrated, ...
Read more : April check up | Views : 3017 | Replies : 4


Neurologist online Apr 6-13

Those with a particular interest in Campath might like to follow this link:

http://www.mssociety.org.uk/applications/discussion/browse_moderated.rm?post_id=55222

Consultant neurologist and researcher Dr Alasdair Coles will be answering your questions online, April 6th-13th.

A member of the MS Society Cambridge Centre for Myelin Repair team, Alasdair is a neurologist working on experimental treatments in MS.

Currently Alasdair's main project is coordinating the trial of beta interferon and Campath-1H. Alasdair is also involved in studying the behaviour of immune cells ...
Read more : Neurologist online Apr 6-13 | Views : 2362 | Replies : 1


Keeping my fingers crossed!

I have been given a chance to participate in the camms224 trial. After carefully weighing up the potential risks and rewards I have decided to go for it. Campath is certainly at the extreme end of MS treatments with some pretty scary potential side effects, but the chance to potentially stop MS in its tracks is far too good to pass up whatever the risks.

I have to have a series of blood tests next ...
Read more : Keeping my fingers crossed! | Views : 4448 | Replies : 10


Quick update

Hi all,

Just a quick word on the Campath trials. The one year report was sent out to either he FDA or ILEX pharmasudicals (I’m not sure who it was going to) but the NP who wrote it showed it to me when I was in for my quarterly appointment. The report was for the folk’s who are on the “2nd study”…. the people who were on the various CRABs drugs but weren’t having any ...
Read more : Quick update | Views : 3321 | Replies : 3


Campath Info

Dear all,

I have not heard much about Campath in the last months. News about Campath looked very promising only one year ago. Anybody knows anything about current research and trials ?

Thanks

Ric
Read more : Campath Info | Views : 8491 | Replies : 15


 

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