This Is MS Multiple Sclerosis Community: Knowledge & Support

Of course, to have two conditions associated does not imply causality, but I think the association between MS and vascular problems cannot be discussed anymore.

A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis

http://www.ncbi.nlm.nih.gov/pubmed/25533300

Abstract
BACKGROUND:
Findings regarding the prevalence of vascular comorbidities in multiple sclerosis (MS) are conflicting.

OBJECTIVE:
The objective of this review is to estimate the ...

This is a recently published article about the BBB breakdown. It is still too early to know whether it is important, but I think it is worthy to have it around here.

http://www.ncbi.nlm.nih.gov/pubmed/25535736

Interleukin-34 Restores Blood-Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells.

Abstract
Interleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected ...

This discussion of NPH is on the MS Discovery Forum site:

http://www.msdiscovery.org/forums/discussion/8114-normal-pressure-hydrocephalus-component-multiple-sclerosis-pathology

short url: http://bit.ly/1JM1aWK

I have been diagnosed with MS for 30 years but it wasn't until 10 years ago I started having walking difficulties. After trying what pharmaceuticals have to offer, I am medication free and I strongly believe and can see a connection with Dr. Zamboni and Dr. Marian Simka with my symptoms. Does anyone know how to contact any of them? --Betsy

Folks,

I am sure many of you are aware of TED talk. If some of you have not, I do suggest you listening to some of the topics on Biology, Health, Brain etc. The insight TED provides is just incredible. The other day, I was listening to this speaker who was explaining why sleep is essential (http://www.ted.com/talks/jeff_iliff_one ... ht_s_sleep) and some of the findings were simply an eye opener ...

The French Neurologist Jean-Martin Charcot, practicing at the Parisian la Pitié-Salpetrière hospital, first described Multiple Sclerosis (Sclérose en Plaques) in 1868. Among other things, he defined MS as a “rigidity disorder”. He thus set the tone in the Neurology profession of an unfortunate prejudice towards MS patients by claiming their “rigidity” symptoms were psychological in origin - signs of neurotic (usually female) hysteria. I now believe it is just this rigidity which is at the ...

J Neurosci. 2014 Oct 29;34(44):14697-706. doi: 10.1523/JNEUROSCI.2111-14.2014.

Sleep restriction impairs blood-brain barrier function.

He J1, Hsuchou H1, He Y1, Kastin AJ1, Wang Y1, Pan W2.
n
Abstract
The blood-brain barrier (BBB) is a large regulatory and exchange interface between the brain and peripheral circulation. We propose that changes of the BBB contribute to many pathophysiological processes in the brain of subjects with chronic sleep restriction (CSR). To achieve CSR that mimics a common pattern of ...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216015/

Results

85 RR-MS, 83 PP-MS and 82 healthy controls were included. ΔCVF was negative in 45/85 (52.9%) RR-MS, 63/83 (75.9%) PP-MS (p = 0.01) and 11/82 (13.4%) controls (p<0.001), while MFVs on both MCAs in sitting position were significantly reduced in RR-MS and PP-MS patients than in control, particularly in EDSS≥5 subgroup (respectively, 42/50, 84% vs. 66/131, 50.3%, p<0.01 and 48.3±2 cm/s vs. 54.6±3 cm/s, p = 0.01). ...

Thrombotic processes in multiple sclerosis as manifestation of innate immune activation

Opinion piece.

Hi sorry if Im replicating (I did do a search and go to the newbie section first).

My sister has Primary Progressive MS, I have just been to see a consultant who does CCSVI, however he said he had little experience of doing CCSVI on primary progressive MS, although they have had some positive results for people with other types of MS, he had only done one operation on one patient with Primary Progressive MS ...