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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Researchers investigating new treatment for MS

A new treatment under investigation for multiple sclerosis (MS) is safe and tolerable in phase I clinical trials, according to a study published August 27, 2014, in Neurology® Neuroimmunology & Neuroinflammation.

The phase I studies were the first to test the drug candidate in humans. Studies with animals showed that the drug, which is called anti-LINGO-1, or BIIB033, may be able to reverse the demyelination of the nerves. Anti-LINGO-1 blocks LINGO-1, a central nervous system ...
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Phase I trial of ALKS 8700 to treat multiple sclerosis begin

Phase I trial of ALKS 8700 to treat multiple sclerosis begins

Ireland-based biopharmaceutical firm Alkermes has started a Phase I clinical trial of ALKS 8700, a novel monomethyl fumarate (MMF) molecule being developed for the treatment of multiple sclerosis (MS).

The trial will assess the safety, tolerability and pharmacokinetics of several oral formulations of ALKS 8700 compared to both placebo and active control groups in approximately 125 healthy volunteers......... Read More - http://www.ms-uk.org/emergingtherapies
Read more : Phase I trial of ALKS 8700 to treat multiple sclerosis begin | Views : 366 | Replies : 0


Over-the-counter antihistamine, Tavist, being tested

http://clinicaltrials.gov/show/NCT02040298

Is anyone taking this over the counter antihistamine and seeing any improvement in their symptoms?
Read more : Over-the-counter antihistamine, Tavist, being tested | Views : 502 | Replies : 2


Could existing common medications help restore myelin in MS?

Could existing common medications help restore myelin in MS patients?

A common cold treatment and seven other drugs already approved for other conditions could help restore a protective coating eroded around neurons in multiple sclerosis patients, according to researchers led by a team at the University of California, San Francisco.

UCSF is spearheading a 50-patient clinical trial of the most promising drug — an over-the-counter antihistamine branded by Novartis as Tavist — that is expected ...
Read more : Could existing common medications help restore myelin in MS? | Views : 660 | Replies : 2


CAMBRIDGE UNIVERSITY DEVELOPED MS DRUG APPROVED BY WATCHDOG

http://www.bbc.com/news/uk-england-camb ... e-27594138
A new drug for treating M.S developed by cambridge university research read the site more information
regards
seeva
Read more : CAMBRIDGE UNIVERSITY DEVELOPED MS DRUG APPROVED BY WATCHDOG | Views : 514 | Replies : 0


Positive phase2 results reported for RPC1063 in relapsing MS

Receptos, Inc. announced that the Phase 2 portion of the RADIANCE trial of its selective S1P1 receptor modulator, RPC1063, in relapsing multiple sclerosis (RMS) met the primary endpoint, reduction in MRI brain lesion activity. The overall safety profile of RPC1063 was consistent with the results of prior trials, and continues to support the differentiation of the drug candidate against other oral agents for treatment of RMS on the market or in clinical development..... Read More ...
Read more : Positive phase2 results reported for RPC1063 in relapsing MS | Views : 429 | Replies : 0


The influence of cannabinoids on neurodegeneration (mice)

another recent research study on cannabinoids. Nothing MS specific, but the usual suspects are all there.
http://onlinelibrary.wiley.com/doi/10.1111/bph.12492/full
Abstract
In an increasingly ageing population, the incidence of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease are rising. While the aetiologies of these disorders are different, a number of common mechanisms that underlie their neurodegenerative components have been elucidated; namely neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced trophic support. Current therapies focus on treatment of ...
Read more : The influence of cannabinoids on neurodegeneration (mice) | Views : 410 | Replies : 0


Tecfidera

I stopped Copaxone for 4 mos to try Tecifedera but got worse, now back on Copaxone.
Read more : Tecfidera | Views : 803 | Replies : 3


Aubagio... any experience?

I have agreed with my neuro to start the aubagio treatment. I have been dmd free for 8 months. Previously on avonex. Turns out that I do need meds because diet, nutrition and gluten free did not keep me in remission. I have an mri appointment and soon to start aubagio. I guess what I am looking for is how this drug is working. My neuro tells me that it is the most tolerated. Do ...
Read more : Aubagio... any experience? | Views : 4482 | Replies : 28


Wanting off Avonex

Hi,
I'm new here. I was diagnosed in September of last year. I am currently taking Avonex injections, Zoloft, Percocet, Dilotid, Ativan, and I most recently Valium and Flexeril. I feel like I am singlehandedly keeping the drug companies in business! :wink:

A little background on me: I'm 28, mother of 4 (8,6,3,2yrs) wife of 10 years, and we live in a small town in New England. ...
Read more : Wanting off Avonex | Views : 609 | Replies : 5


 

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