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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Hype? Rituximab

As we all know there are multitudes of drugs in trial.

Rituximab is being trialled with RR, SP and PP sufferers. Although other threads have discussed the possibility of MS being one disease with the immune system response / or not, differentiating between the various types.

The media coverage of Rituximab has been very upbeat as illustrated below:

"In patients who have been treated with rituximab and haven't responded to other treatments, Dr. Stuve says, ...
Read more : Hype? Rituximab | Views : 2042 | Replies : 3


Anyone Using IVIGs?

My neuro has suggested IVIG (intravenous immunoglobulins) for my MS.

I have seen some information out there on the internet about IVIG used for MS in Europe and Israel. But no one seems to know much about it.

Anyone using IVIGs out there?
Read more : Anyone Using IVIGs? | Views : 1469 | Replies : 1


Anyone Using Cellcept?

I have been on Cellcept (2g daily) for over a year now. I also take Avonex. This has coincided with a quiet period in my MS but I do not know if I can attribute this to the Cellcept.

Most doctors are familiar with Cellcept for rheumatoid arthritis and lupus, as well as its intended uses for organ transplant patients.

Any other Cellcept users out there?
Read more : Anyone Using Cellcept? | Views : 2282 | Replies : 2


FDA Makes Earliest Stages Of Clinical Trials More Efficient

An interesting FDA development that could speed the drug approval process in the US...



FDA Issues Advice to Make Earliest Stages Of Clinical Drug Development More Efficient

January 12, 2006 - The Food and Drug Administration (FDA) today announced steps to advance the earliest phases of clinical research in the development of innovative medical treatments. FDA’s goal is to improve the process for bringing safe and effective drugs for potentially serious and life-threatening diseases, such ...
Read more : FDA Makes Earliest Stages Of Clinical Trials More Efficient | Views : 1530 | Replies : 2


HSCT

Like many I want to halt this curse until some better treatments come along. I share the views of this guy who posted on the BCP site:


HSCT

This procedure is very efficious on early RRMS patients, when inflammation dominates. As the spectrum shifts from inflammatory in nature to progressive, it becomes less effective. It is not at all effective for primary progressive MS. Data suggest inflammation is held in check for at least 5-6 ...
Read more : HSCT | Views : 1302 | Replies : 0


MS drugs

Dear all,

The UK has an MS website called MSRC. They have a list of drugs (licenced and it trial) on the site. The list isn't anywhere near as comprehensive as Dignans, but when you click on each drug there is a link to press articles etc.

Tovaxin, Neurovax and Rituximab look the best of the bunch to me.

http://www.msrc.co.uk/index.cfm?fuseact ... N=57563484

Ian
Read more : MS drugs | Views : 1956 | Replies : 4


ACTS

Read more : ACTS | Views : 1121 | Replies : 0


Rituximab

Read more : Rituximab | Views : 1292 | Replies : 0


Rituxan Phase III for PPMS

I thought this was a typo a week or two ago when I saw mention of the latest Rituxan trial for PPMS being a Phase III trial, but this exerpt from a press release today says it again, so I guess it's not a typo.



Genentech Announces Full Year and Fourth Quarter 2005 Results

Tuesday January 10, 4:29 pm ET

Record Annual Revenues of $6.6 Billion Drive Year-Over-Year Non-GAAP EPS Growth of 54 Percent

SOUTH ...
Read more : Rituxan Phase III for PPMS | Views : 1551 | Replies : 0


HP184

Here's a drug (Sanofi-aventis' HP184) in the early stages that might be helpful for MS and other conditions.



Tireless quest for a cure, Lorenzo-style

Globe & Mail - January 9, 2006...

Of particular interest is a drug called HP184, a sodium and potassium channel blocker that has been tested on spinal cord patients. When Jacob's parents brought the drug, made by Sanofi-aventis, to the attention of doctors, none had heard of it.

"They're very proactive, ...
Read more : HP184 | Views : 2197 | Replies : 1


 

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