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A board to discuss future MS therapies in early stage (Phase I or II) trials.

BHT 3009 research

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Oral fumurate research

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TGN1412

Parexel Drug Trial Had Shortfalls, U.K. Investigation Says

Parexel International Corp., which ran a clinical trial that left six men with multiple organ failure earlier this year, didn't have a doctor with adequate training and experience screening the patients, the U.K. health regulator said.

Parexel, based in Waltham, Massachusetts, failed to ensure that closely held German biotechnology company TeGenero AG, which developed the medicine, had proper insurance to cover the volunteers, the London-based Medicines ...
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Synta

Dignan,

Trials not for MS, but something to keep in mind.

Ian


Synta launches human trials for anti-inflammatory drug

Synta Pharmaceuticals Corp. has launched two new midstage human clinical trials to test an anti-inflammatory drug.
The Lexington, Mass.-based private company said it had began dosing patients in two separate Phase II trials regarding the compound apilimod mesylate. One trial will focus on rheumatoid arthritis and the other will target common variable immunodeficiency, a condition ...
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Serum

Dignan,

I think the following can be moved from Phase I to Phase II.

Ian


Cambrex to Produce Serum for Trial

Cambrex to Make Serum for Merrimack Pharmaceuticals Autoimmune Disease Study.

Cambrex Corp. said Tuesday one of its subsidiaries will produce a serum for a Merrimack Pharmaceuticals clinical study on autoimmune disease treatments.

The subsidiary, Cambrex Bio Science Hopkinton Inc., will produce trial quantities of Merrimack's lead drug candidate, MM-093, for the Phase II ...
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Bone Marrow Transplantation

The following appeared on the Canada MS Society 'Ask an Expert' section. The answer was given by Dr Mark Freedman who is oversseing the project. It's good to see that those who have been througt it have not seen a recurrence of their MS and some have seen improvements.

Ian

Q :

A few months ago I saw a program on W-5 about MS patients who were undergoing bone marrow transplantation. Can you tell me ...
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Allon drugs

Scientific Paper Confirms Mechanism of Allon's Drugs

Allon Therapeutics Inc., The Neuro Protection Company(TM), today announced that results of a preclinical study published in the Journal of Molecular Neuroscience demonstrate that the cellular mechanism that gives neuroprotective properties to its clinical-stage products also occurs in the Company's pipeline of preclinical-stage product candidates.
Dr. Illana Gozes, Chief Scientific Officer of Allon and the corresponding author for the study, said the neuroprotective activity of the Company's ...
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p75NTR

Mentions other brain disease, so I'm assuming MS included.

The really interesting bit is:

"In further tests, the research team discovered that the compounds can also inhibit the death of oligodendrocytes, the cells in the central nervous system that form myelin, the insulating sheath surrounding nerve cells.

Normally, oligodendrocytes die when exposed to proneurotrophins – precursor forms of neurotrophins that have been implicated as agents of tissue damage in multiple sclerosis, spinal cord injury and ...
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Extracorporeal photochemotherapy

Never heard of this treatment before.




Extracorporeal photochemotherapy: a safety and tolerability pilot study with preliminary efficacy results in refractory relapsing-remitting multiple sclerosis.

Neurol Sci. 2006 Apr;27(1):24-32.
Cavaletti G, Perseghin P, Dassi M, Cavarretta R, Frigo M, Caputo D, Stanzani L, Tagliabue E, Zoia C, Grimaldi M, Isella V, Rota S, Ferrarese C, Frattola L.
D.N.T.B., University of Milano-Bicocca, Via Cadore 48, I-20052, Monza (MI), Italy.

Extracorporeal photochemotherapy (ECP) is an immunomodulating procedure consisting of ...
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AlphaRX

AlphaRx Enters a Collaboration to Develop Novel Compounds for Central Nervous System Disorders

AlphaRx and PharmaSeed Collaborate to Develop New Drugs From a New Class of Small Molecules for the Potential Treatment of Central Nervous System Disorders Such as Stroke and Multiple Sclerosis.

AlphaRx Inc., an emerging biopharmaceutical company, announced today that it has entered into a collaboration with PharmaSeed Ltd. of Israel, a bio-pharmaceutical company specializing in drug discovery and early development phases for ...
Read more : AlphaRX | Views : 1288 | Replies : 0


 

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