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MS? Immune system or nervous system?

Does multiple sclerosis stem from immune system and not the nervous system?

The genetic starting point for autoimmune diseases like multiple sclerosis (MS) and type 1 diabetes may be TK, according to a study published in Nature on October 29, 2014.

A multifaceted team of researchers developed a new mathematical formula to scour existing DNA databases in order to determine why inherited DNA variations contribute to disease. The sequencing techniques they developed examined epigenetic characteristics ...
Read more : MS? Immune system or nervous system? | Views : 287 | Replies : 0


New DNA software may improve MS diagnosis and treatment

Researchers from UC San Francisco, the Broad Institute of MIT and Harvard, and Yale School of Medicine recently developed a software tool that helps researchers understand the complex genetic origins of many autoimmune diseases and, ultimately, to better diagnose and treat them. The study was published yesterday in Nature...... Read More - http://www.ms-uk.org/genetics
Read more : New DNA software may improve MS diagnosis and treatment | Views : 253 | Replies : 0


New gene variants may relate to MS susceptibility

Approximately 110 multiple genetic variations were previously identified by genome-wide association studies (GWAS) to be associated with Multiple Sclerosis (MS). Now, that number has increased, with more than 159 genetic variants identified, thanks to new research presented by Philip De Jager, M.D., of Brigham and Women’s Hospital, Harvard Medical School and the International MS Genetics Consortium at the ACTRIMS-ECTRIMS conference in Boston...... Read More - http://www.ms-uk.org/genetics
Read more : New gene variants may relate to MS susceptibility | Views : 459 | Replies : 1


Gene involvement in mechanisms of neurodegeneration.....

Gene involvement in mechanisms of neurodegeneration and neuroinflammation

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.

Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds R.

Abstract

Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead ...
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Nerve conduction velocity gene linked to multiple sclerosis

Evidence found in both human multiple sclerosis patients and experimental mouse models, according to research published in the American Journal of Pathology.

A new study published in The American Journal of Pathology identifies a novel gene that controls nerve conduction velocity. Investigators report that even minor reductions in conduction velocity may aggravate disease in multiple sclerosis (MS) patients and in mice bred for the MS-like condition experimental autoimmune encephalomyelitis (EAE)...... Read more- http://www.ms-uk.org/genetics
Read more : Nerve conduction velocity gene linked to multiple sclerosis | Views : 404 | Replies : 1


Multiple sclerosis discovery may explain gender gap

A key difference in the brains of male and female MS patients may explain why more women than men get the disease, a study suggests.

Scientists at Washington University School of Medicine in the US found higher levels of protein S1PR2 in tests on the brains of female mice and dead women with MS than in male equivalents.....Read More - http://www.ms-uk.org/genetics
Read more : Multiple sclerosis discovery may explain gender gap | Views : 2557 | Replies : 0


Genome study identifies three possible drug candidates...

Genome study identifies three possible drug candidates for autoimmune diseases

New pharmaceuticals to fight autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis and psoriasis, may be identified more effectively by adding genome analysis to standard drug screening, according to a new study by a research team led by UC San Francisco and Harvard researchers, in collaboration with Tempero and GlaxoSmithKlein.

In a study reported online April 17, 2014 in the journal Immunity, the scientists combined ...
Read more : Genome study identifies three possible drug candidates... | Views : 508 | Replies : 1


Researchers testing gene therapy to thwart effects of MS

In patients with multiple sclerosis, the body turns on itself, launching an immune system attack that destroys the coating around nerve fibers in the central nervous system, leaving them exposed like bare wires. Similar to exposed electrical lines, the unprotected fibers touch and short out, leading to the neurodegenerative effects that are a hallmark of multiple sclerosis...... Read More - http://www.ms-uk.org/genetics
Read more : Researchers testing gene therapy to thwart effects of MS | Views : 630 | Replies : 0


Positive clinical performance of MSPrecise

DioGenix reports positive clinical performance of molecular diagnostic MSPrecise for Multiple Sclerosis

DioGenix, Inc. announced today new data supporting the clinical validation of MSPrecise®, its proprietary next-generation sequencing (NGS) assay for the identification of patients with multiple sclerosis (MS) at first clinical presentation. The prospective study met its primary endpoint by demonstrating the ability of MSPrecise to diagnose patients with MS. The test performed consistently with previous clinical studies, having a specificity of 82% while ...
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Researchers assess familial risks for MS ......

Researchers assess familial risks for MS using population registers, health care registries

Even though multiple sclerosis is largely caused by genetic factors, the risk of patients' relatives developing the disease is lower than previously assumed. This is the conclusion of a new population registry-based study, published in the scientific journal Brain...... Read More - http://www.ms-uk.org/genetics
Read more : Researchers assess familial risks for MS ...... | Views : 520 | Replies : 0


 

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