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Identifying MS gene mutations could lead to personalised....

Identifying MS gene mutations could lead to personalised treatments

Personalised medicine, often applied to treat cancer, may be possible for patients with multiple sclerosis as well. Certain patients respond differently to certain multiple sclerosis medications, such as interferon-β (IFNβ), and researchers at San Raffaele Scientific Institute in Milan may have an answer as to why.... Read More - http://www.ms-uk.org/genetics
Read more : Identifying MS gene mutations could lead to personalised.... | Views : 494 | Replies : 0


Gene that "triggers" multiple sclerosis identified

New research identifies a pivotal gene in multiple sclerosis, linking it to the most important genetic factor that drives the condition..... Read More - http://www.ms-uk.org/genetics
Read more : Gene that "triggers" multiple sclerosis identified | Views : 537 | Replies : 0


Researcher improves methodology ......

Researcher improves methodology for predicting genetic ‘mutations’

Researchers around the world have sequenced the genomes of patients living with from common, multi-gene diseases, looking for common mutations in their control regions. However these studies produce hundreds of mutations, many of which prove to be benign..... Read More - http://www.ms-uk.org/genetics
Read more : Researcher improves methodology ...... | Views : 300 | Replies : 0


Gene linked to interferon-beta treatment

A new study led by investigators at Brigham and Womens Hospital (BWH) reports the discovery of a genetic variant associated with a patients likelihood of responding to interferon-beta, one of the medications used in treating multiple sclerosis...... Read More - http://www.ms-uk.org/genetics
Read more : Gene linked to interferon-beta treatment | Views : 440 | Replies : 0


Genetic risk factor uncovered

Researchers at the University of Illinois at Chicago have identified a genetic variation that in women significantly increases their risk of developing multiple sclerosis. The report is published in the journal ASN Neuro.

The variant occurs almost twice as often among women with MS as in women without the disease, making it "one of the strongest genetic risk factors for MS discovered to date," said senior author Doug Feinstein, professor of anesthesiology at UIC and ...
Read more : Genetic risk factor uncovered | Views : 634 | Replies : 0


MS? Immune system or nervous system?

Does multiple sclerosis stem from immune system and not the nervous system?

The genetic starting point for autoimmune diseases like multiple sclerosis (MS) and type 1 diabetes may be TK, according to a study published in Nature on October 29, 2014.

A multifaceted team of researchers developed a new mathematical formula to scour existing DNA databases in order to determine why inherited DNA variations contribute to disease. The sequencing techniques they developed examined epigenetic characteristics ...
Read more : MS? Immune system or nervous system? | Views : 690 | Replies : 0


New DNA software may improve MS diagnosis and treatment

Researchers from UC San Francisco, the Broad Institute of MIT and Harvard, and Yale School of Medicine recently developed a software tool that helps researchers understand the complex genetic origins of many autoimmune diseases and, ultimately, to better diagnose and treat them. The study was published yesterday in Nature...... Read More - http://www.ms-uk.org/genetics
Read more : New DNA software may improve MS diagnosis and treatment | Views : 584 | Replies : 0


New gene variants may relate to MS susceptibility

Approximately 110 multiple genetic variations were previously identified by genome-wide association studies (GWAS) to be associated with Multiple Sclerosis (MS). Now, that number has increased, with more than 159 genetic variants identified, thanks to new research presented by Philip De Jager, M.D., of Brigham and Women’s Hospital, Harvard Medical School and the International MS Genetics Consortium at the ACTRIMS-ECTRIMS conference in Boston...... Read More - http://www.ms-uk.org/genetics
Read more : New gene variants may relate to MS susceptibility | Views : 751 | Replies : 1


Gene involvement in mechanisms of neurodegeneration.....

Gene involvement in mechanisms of neurodegeneration and neuroinflammation

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.

Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds R.

Abstract

Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead ...
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Nerve conduction velocity gene linked to multiple sclerosis

Evidence found in both human multiple sclerosis patients and experimental mouse models, according to research published in the American Journal of Pathology.

A new study published in The American Journal of Pathology identifies a novel gene that controls nerve conduction velocity. Investigators report that even minor reductions in conduction velocity may aggravate disease in multiple sclerosis (MS) patients and in mice bred for the MS-like condition experimental autoimmune encephalomyelitis (EAE)...... Read more- http://www.ms-uk.org/genetics
Read more : Nerve conduction velocity gene linked to multiple sclerosis | Views : 740 | Replies : 1


 

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