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Casting light on multiple sclerosis heterogeneity.....

Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology

Clinical heterogeneity in multiple sclerosis is the rule. Evidence suggests that HLA-DRB1*15 may play a role in clinical outcome.

Spinal cord pathology is common and contributes significantly to disability in the disease.

The influence of HLA-DRB1*15 on multiple sclerosis spinal cord pathology is unknown..... Read More - http://www.ms-uk.org/index.cfm/genetics
Read more : Casting light on multiple sclerosis heterogeneity..... | Views : 1134 | Replies : 0


Assessing interactions between HLA-DRB1*15 and Epstein-Barr

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Summary: This study from the UK looked at gene-environment interactions in MS.

The researchers looked at the interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). They found that individuals exposed to both factors were at an increased risk of disease. Both DRB1-15 and IM status were independent predictors of disease, while there interaction term was not, but interaction on an ...
Read more : Assessing interactions between HLA-DRB1*15 and Epstein-Barr | Views : 914 | Replies : 0


Genetic and infectious profiles of Japanese MS patients

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Abstract

Background
Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS ...
Read more : Genetic and infectious profiles of Japanese MS patients | Views : 1713 | Replies : 1


Scientists deepen genetic understanding of MS

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Five scientists, including two from Simon Fraser University, have discovered that 30 per cent of our likelihood of developing Multiple Sclerosis (MS) can be explained by 475,806 genetic variants in our genome. Genome-wide Association Studies (GWAS) commonly screen these variants, looking for genetic links to diseases.

Corey Watson, a recent SFU doctoral graduate in biology, his thesis supervisor SFU biologist Felix Breden and three scientists in the United Kingdom have just had their findings ...
Read more : Scientists deepen genetic understanding of MS | Views : 2911 | Replies : 0


Gene could be used to treat Multiple Sclerosis

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New treatments for multiple sclerosis (MS) and other auto-immune diseases could flow from an important discovery made by scientists at NUI Maynooth.

They were trying to understand the role of a gene called Pellino3 and how it comes into play when a person develops a viral infection.

They found it acts as a “braking system” that helps to regulate the immune response during infection. Details of the work, led by Paul Moynagh, director of ...
Read more : Gene could be used to treat Multiple Sclerosis | Views : 1655 | Replies : 0


Transcription profile distinguishes subgroups in MS

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Patients with multiple sclerosis (MS) can be differentiated according to their transcription profile, according to a study published in the Sept. 26 issue of Science Translational Medicine.

Linda Ottoboni, R.N., from the Brigham and Women's Hospital in Boston, and colleagues examined the structure of an MS patient population using a transcriptional profile generated from peripheral blood mononuclear cells.

Among 141 untreated patients, the researchers identified two subsets of MS patients (MSA and MSB). This ...
Read more : Transcription profile distinguishes subgroups in MS | Views : 829 | Replies : 0


does ms run in families

I was really interested to hear there could be a gene that identifies the risk of ms, i have ms with four aunties ( mum's sister's ) and 2 cousins female and all have either lupis, addisons and raynhaurds anyone else found a similar pattern in there family i am interested as i have daughter who at 9 already is showing signs of raynhaurd's

hazexx :?:
Read more : does ms run in families | Views : 2474 | Replies : 10


Clues to causes of nerve cell degeneration

Clues to causes of nerve cell degeneration provided by spasticity gene finding

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The discovery of a gene that causes a form of hereditary spastic paraplegia (HSP) may provide scientists with an important insight into what causes axons, the stems of our nerve cells, to degenerate in conditions such as multiple sclerosis.

In the Journal of Clinical Investigation, an international team of scientists led by Dr Evan Reid at the University of Cambridge, and Dr ...
Read more : Clues to causes of nerve cell degeneration | Views : 1838 | Replies : 0


Three novel Multiple Sclerosis susceptibility loci identifie

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Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.

Nikolaos A. Patsopoulos, M.D., Ph.D., from the Brigham and Women's Hospital in Boston, and colleagues investigated MS susceptibility and explored the functional consequences of novel susceptibility loci.

They performed a one-stage meta-analysis of seven genome-wide association studies involving 2,529,394 unique single nucleotide polymorphisms obtained from 5,545 patients with MS ...
Read more : Three novel Multiple Sclerosis susceptibility loci identifie | Views : 1539 | Replies : 0


Right acting/right thinking TIMP-1 gene transfer

Right acting/right thinking TIMP-1 gene transfer?


Regarding the concept of MMP-9s being responsible for most myelin damage, I must confess that I have never really given all the TIMPs-1 a clean bill of health.

They are suppose to insure that the MMP-9s only eat the BAD STUFF.(dead/damaged/dying things)

What if they are at fault and are directing the MMP-9s to the Myelin for LUNCH?????

Traitors for sure - but is there reasonable evidence to ...
Read more : Right acting/right thinking TIMP-1 gene transfer | Views : 1168 | Replies : 0


 

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