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Study to investigate the human genome in MS announced

The National Institutes of Health (NIH) awarded Benaroya Research Institute at Virginia Mason (BRI) a $1.9 million grant to find marks in the human genome which can explain why some white blood cells cause damage to the spinal cord and brain in multiple sclerosis (MS). This is the first study to look for molecular changes in the genome of specific immune cells responsible for the devastation caused by MS. The broad-based study will determine the ...
Read more : Study to investigate the human genome in MS announced | Views : 566 | Replies : 0


Unraveling complex genetic interplay for MS risks

A Western Australia-cohort of patients has been used to study the risk modifying role of specific genes suspected to contribute to one’s predisposition to multiple sclerosis (MS).

MS is the most common cause of neurological disabilities in young adults with an estimated 25,000 cases nationwide and a higher prevalence among women than men in most Western countries...... Read More - http://www.ms-uk.org/index.cfm/genetics
Read more : Unraveling complex genetic interplay for MS risks | Views : 743 | Replies : 0


Absence of gene leads to earlier, more severe case of MS

A UC San Francisco-led research team has identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to progress more quickly than others to a debilitating stage of the disease. This finding could lead to the development of a test to help physicians tailor treatments for MS patients.

Researchers found that the absence of the gene Tob1 in CD4+ T cells, a type of immune cell, was the key to early onset ...
Read more : Absence of gene leads to earlier, more severe case of MS | Views : 722 | Replies : 0


Casting light on multiple sclerosis heterogeneity.....

Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology

Clinical heterogeneity in multiple sclerosis is the rule. Evidence suggests that HLA-DRB1*15 may play a role in clinical outcome.

Spinal cord pathology is common and contributes significantly to disability in the disease.

The influence of HLA-DRB1*15 on multiple sclerosis spinal cord pathology is unknown..... Read More - http://www.ms-uk.org/index.cfm/genetics
Read more : Casting light on multiple sclerosis heterogeneity..... | Views : 1311 | Replies : 0


Assessing interactions between HLA-DRB1*15 and Epstein-Barr

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Summary: This study from the UK looked at gene-environment interactions in MS.

The researchers looked at the interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). They found that individuals exposed to both factors were at an increased risk of disease. Both DRB1-15 and IM status were independent predictors of disease, while there interaction term was not, but interaction on an ...
Read more : Assessing interactions between HLA-DRB1*15 and Epstein-Barr | Views : 1050 | Replies : 0


Genetic and infectious profiles of Japanese MS patients

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Abstract

Background
Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS ...
Read more : Genetic and infectious profiles of Japanese MS patients | Views : 1841 | Replies : 1


Scientists deepen genetic understanding of MS

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Five scientists, including two from Simon Fraser University, have discovered that 30 per cent of our likelihood of developing Multiple Sclerosis (MS) can be explained by 475,806 genetic variants in our genome. Genome-wide Association Studies (GWAS) commonly screen these variants, looking for genetic links to diseases.

Corey Watson, a recent SFU doctoral graduate in biology, his thesis supervisor SFU biologist Felix Breden and three scientists in the United Kingdom have just had their findings ...
Read more : Scientists deepen genetic understanding of MS | Views : 3050 | Replies : 0


Gene could be used to treat Multiple Sclerosis

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New treatments for multiple sclerosis (MS) and other auto-immune diseases could flow from an important discovery made by scientists at NUI Maynooth.

They were trying to understand the role of a gene called Pellino3 and how it comes into play when a person develops a viral infection.

They found it acts as a “braking system” that helps to regulate the immune response during infection. Details of the work, led by Paul Moynagh, director of ...
Read more : Gene could be used to treat Multiple Sclerosis | Views : 1894 | Replies : 0


Transcription profile distinguishes subgroups in MS

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Patients with multiple sclerosis (MS) can be differentiated according to their transcription profile, according to a study published in the Sept. 26 issue of Science Translational Medicine.

Linda Ottoboni, R.N., from the Brigham and Women's Hospital in Boston, and colleagues examined the structure of an MS patient population using a transcriptional profile generated from peripheral blood mononuclear cells.

Among 141 untreated patients, the researchers identified two subsets of MS patients (MSA and MSB). This ...
Read more : Transcription profile distinguishes subgroups in MS | Views : 950 | Replies : 0


does ms run in families

I was really interested to hear there could be a gene that identifies the risk of ms, i have ms with four aunties ( mum's sister's ) and 2 cousins female and all have either lupis, addisons and raynhaurds anyone else found a similar pattern in there family i am interested as i have daughter who at 9 already is showing signs of raynhaurd's

hazexx :?:
Read more : does ms run in families | Views : 2644 | Replies : 10


 

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