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MS research appeal

An Orcadian geneticist who is researching the causes of MS in the Northern Isles, is asking people in Orkney to help create a list of all the people with Orkney and Shetland ancestors who have had Multiple Sclerosis.

Dr Jim Wilson who works for the Centre for Population Health Services at the University of Edinburgh said it is important to work out the degree to which MS is genetic in Orkney and Shetland, through building ...
Read more : MS research appeal | Views : 472 | Replies : 0


Mapping reveals 110 multiple sclerosis risk genes

Norwegian researchers have mapped genetic variations associated with an increased risk of multiple sclerosis (MS) and myasthenia gravis (MG), bringing science one step closer to understanding these serious autoimmune disorders.

The Norwegian researchers have taken part in an international cooperative effort to map 110 genetic variations that increase the risk of MS and MG. Most of these genetic variations have been mapped in recent years.......Read More - http://www.ms-uk.org/genetics
Read more : Mapping reveals 110 multiple sclerosis risk genes | Views : 594 | Replies : 0


Genetic breakthrough brings scientists closer to M.S. cure

A DR. DAVID BOOTH FROM WESTMEAD GENTIC STUDIES FINDS VERY CLOSE TO IDENTIFIED THE GENES ASSOSIATED WITH M.S MORE DETAILS FROM THE WEB SITE http://www.abc.net.au/news/2013-09-30/b ... re/4987984
REGARDS
SEEVA :roll:
Read more : Genetic breakthrough brings scientists closer to M.S. cure | Views : 8825 | Replies : 1


New genetic study may help unravel multiple sclerosis

A major milestone has been reached on the path to finding a cure for multiple sclerosis (MS), researchers say.

A group of international scientists, including an Australian contingent, has discovered 48 previously unknown genes that influence the risk of developing MS...... Read more - http://www.ms-uk.org/genetics
Read more : New genetic study may help unravel multiple sclerosis | Views : 1195 | Replies : 0


Study to investigate the human genome in MS announced

The National Institutes of Health (NIH) awarded Benaroya Research Institute at Virginia Mason (BRI) a $1.9 million grant to find marks in the human genome which can explain why some white blood cells cause damage to the spinal cord and brain in multiple sclerosis (MS). This is the first study to look for molecular changes in the genome of specific immune cells responsible for the devastation caused by MS. The broad-based study will determine the ...
Read more : Study to investigate the human genome in MS announced | Views : 676 | Replies : 0


Unraveling complex genetic interplay for MS risks

A Western Australia-cohort of patients has been used to study the risk modifying role of specific genes suspected to contribute to one’s predisposition to multiple sclerosis (MS).

MS is the most common cause of neurological disabilities in young adults with an estimated 25,000 cases nationwide and a higher prevalence among women than men in most Western countries...... Read More - http://www.ms-uk.org/index.cfm/genetics
Read more : Unraveling complex genetic interplay for MS risks | Views : 866 | Replies : 0


Absence of gene leads to earlier, more severe case of MS

A UC San Francisco-led research team has identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to progress more quickly than others to a debilitating stage of the disease. This finding could lead to the development of a test to help physicians tailor treatments for MS patients.

Researchers found that the absence of the gene Tob1 in CD4+ T cells, a type of immune cell, was the key to early onset ...
Read more : Absence of gene leads to earlier, more severe case of MS | Views : 841 | Replies : 0


Casting light on multiple sclerosis heterogeneity.....

Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology

Clinical heterogeneity in multiple sclerosis is the rule. Evidence suggests that HLA-DRB1*15 may play a role in clinical outcome.

Spinal cord pathology is common and contributes significantly to disability in the disease.

The influence of HLA-DRB1*15 on multiple sclerosis spinal cord pathology is unknown..... Read More - http://www.ms-uk.org/index.cfm/genetics
Read more : Casting light on multiple sclerosis heterogeneity..... | Views : 1435 | Replies : 0


Assessing interactions between HLA-DRB1*15 and Epstein-Barr

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Summary: This study from the UK looked at gene-environment interactions in MS.

The researchers looked at the interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). They found that individuals exposed to both factors were at an increased risk of disease. Both DRB1-15 and IM status were independent predictors of disease, while there interaction term was not, but interaction on an ...
Read more : Assessing interactions between HLA-DRB1*15 and Epstein-Barr | Views : 1165 | Replies : 0


Genetic and infectious profiles of Japanese MS patients

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Abstract

Background
Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS ...
Read more : Genetic and infectious profiles of Japanese MS patients | Views : 1956 | Replies : 1


 

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