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Transcription profile distinguishes subgroups in MS

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Patients with multiple sclerosis (MS) can be differentiated according to their transcription profile, according to a study published in the Sept. 26 issue of Science Translational Medicine.

Linda Ottoboni, R.N., from the Brigham and Women's Hospital in Boston, and colleagues examined the structure of an MS patient population using a transcriptional profile generated from peripheral blood mononuclear cells.

Among 141 untreated patients, the researchers identified two subsets of MS patients (MSA and MSB). This ...
Read more : Transcription profile distinguishes subgroups in MS | Views : 1011 | Replies : 0


does ms run in families

I was really interested to hear there could be a gene that identifies the risk of ms, i have ms with four aunties ( mum's sister's ) and 2 cousins female and all have either lupis, addisons and raynhaurds anyone else found a similar pattern in there family i am interested as i have daughter who at 9 already is showing signs of raynhaurd's

hazexx :?:
Read more : does ms run in families | Views : 2716 | Replies : 10


Clues to causes of nerve cell degeneration

Clues to causes of nerve cell degeneration provided by spasticity gene finding

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The discovery of a gene that causes a form of hereditary spastic paraplegia (HSP) may provide scientists with an important insight into what causes axons, the stems of our nerve cells, to degenerate in conditions such as multiple sclerosis.

In the Journal of Clinical Investigation, an international team of scientists led by Dr Evan Reid at the University of Cambridge, and Dr ...
Read more : Clues to causes of nerve cell degeneration | Views : 2094 | Replies : 0


Three novel Multiple Sclerosis susceptibility loci identifie

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Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.

Nikolaos A. Patsopoulos, M.D., Ph.D., from the Brigham and Women's Hospital in Boston, and colleagues investigated MS susceptibility and explored the functional consequences of novel susceptibility loci.

They performed a one-stage meta-analysis of seven genome-wide association studies involving 2,529,394 unique single nucleotide polymorphisms obtained from 5,545 patients with MS ...
Read more : Three novel Multiple Sclerosis susceptibility loci identifie | Views : 1846 | Replies : 0


Right acting/right thinking TIMP-1 gene transfer

Right acting/right thinking TIMP-1 gene transfer?


Regarding the concept of MMP-9s being responsible for most myelin damage, I must confess that I have never really given all the TIMPs-1 a clean bill of health.

They are suppose to insure that the MMP-9s only eat the BAD STUFF.(dead/damaged/dying things)

What if they are at fault and are directing the MMP-9s to the Myelin for LUNCH?????

Traitors for sure - but is there reasonable evidence to ...
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HLA-DRB1*15:01 and multiple sclerosis: a female association?

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Abstract

Background: The association between multiple sclerosis (MS) and the HLA-DRB1*15:01 haplotype has been proven to be strong, but its molecular basis remains unclear. Vitamin D receptor (VDR) gene variants and sex have been proposed to modulate this association.

Objectives: 1) Test the association of MS with *15:01 and VDR variants; 2) check whether VDR variants and/or sex modulate the risk conferred by *15:01; 3) study whether *15:01, VDR variants and/or sex affect HLA ...
Read more : HLA-DRB1*15:01 and multiple sclerosis: a female association? | Views : 2004 | Replies : 0


Genetic clues to what triggers Multiple Sclerosis

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Around 30 genetic risk factors for developing multiple sclerosis have been discovered by a UK-led team.

It brings to more than 50 the total number of genetic clues to the disease.

The research, published in Nature, will help identify risk factors and perhaps future treatments or even a cure, said the MS Society.

Most of the genes are linked to immunity, backing the idea that the disease is triggered when the immune system turns ...
Read more : Genetic clues to what triggers Multiple Sclerosis | Views : 4355 | Replies : 2








 

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