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Three novel Multiple Sclerosis susceptibility loci identifie

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Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.

Nikolaos A. Patsopoulos, M.D., Ph.D., from the Brigham and Women's Hospital in Boston, and colleagues investigated MS susceptibility and explored the functional consequences of novel susceptibility loci.

They performed a one-stage meta-analysis of seven genome-wide association studies involving 2,529,394 unique single nucleotide polymorphisms obtained from 5,545 patients with MS ...
Read more : Three novel Multiple Sclerosis susceptibility loci identifie | Views : 1727 | Replies : 0


Right acting/right thinking TIMP-1 gene transfer

Right acting/right thinking TIMP-1 gene transfer?


Regarding the concept of MMP-9s being responsible for most myelin damage, I must confess that I have never really given all the TIMPs-1 a clean bill of health.

They are suppose to insure that the MMP-9s only eat the BAD STUFF.(dead/damaged/dying things)

What if they are at fault and are directing the MMP-9s to the Myelin for LUNCH?????

Traitors for sure - but is there reasonable evidence to ...
Read more : Right acting/right thinking TIMP-1 gene transfer | Views : 1264 | Replies : 0


HLA-DRB1*15:01 and multiple sclerosis: a female association?

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Abstract

Background: The association between multiple sclerosis (MS) and the HLA-DRB1*15:01 haplotype has been proven to be strong, but its molecular basis remains unclear. Vitamin D receptor (VDR) gene variants and sex have been proposed to modulate this association.

Objectives: 1) Test the association of MS with *15:01 and VDR variants; 2) check whether VDR variants and/or sex modulate the risk conferred by *15:01; 3) study whether *15:01, VDR variants and/or sex affect HLA ...
Read more : HLA-DRB1*15:01 and multiple sclerosis: a female association? | Views : 1889 | Replies : 0


Genetic clues to what triggers Multiple Sclerosis

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Around 30 genetic risk factors for developing multiple sclerosis have been discovered by a UK-led team.

It brings to more than 50 the total number of genetic clues to the disease.

The research, published in Nature, will help identify risk factors and perhaps future treatments or even a cure, said the MS Society.

Most of the genes are linked to immunity, backing the idea that the disease is triggered when the immune system turns ...
Read more : Genetic clues to what triggers Multiple Sclerosis | Views : 4237 | Replies : 2








genetic counselor says......

An intersting comment by my UBC MS clinic geneticist " 80% of those with MS have no relatives with MS, 20% have another relative with MS, and it's very rare to have as many relatives as you do with MS!"
I have 2 first cousins, one 1st cousin once removed, four aunts, and two uncles who all have MS. All on my Mom's side. (the aunts & uncles are my Mom's 1/2 sisters and brothers) ...
Read more : genetic counselor says...... | Views : 4541 | Replies : 5




Epigenetics

Hi,
I just watched a really interesting programme about identical twins with the same genetics/DNA etc. The programme was about epigenetics and how the enviroment can switch genes on and off which can lead to one identical twin suffering from a disease i.e lukemia or Type 1 diabetes and the other twin not suffering from it. Because they share the same genes there is an enviromental factor (either from the womb-life experiences) that changes the ...
Read more : Epigenetics | Views : 2110 | Replies : 4


 

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