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Gilenya, or Fingolimod, is the first approved oral disease modifying drug for MS.

Actual details on reduced Lymphocytes count?

I tried doing a search to find the actual numeric effects on cell counts of circulating Lymphocytes before and after being on Gilenya. I didn't find it. The best I found was an approximation for mice in an experiment, who I would assume would of been on much more severe doses.

I would love to see the data from the Phase II and Phase III trials; which used different dosages? Is this data available anywhere? ...
Read more : Actual details on reduced Lymphocytes count? | Views : 1375 | Replies : 3


Gilenya fails to win NICE backing in draft guidance

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The UK's health cost body National Institute for Health and Clinical Excellence, or NICE, in its revised draft guidance did not recommend Swiss pharmaceutical giant Novartis' multiple sclerosis pill Gilenya, as it believes the drug would not be cost effective for the National Health Service, or NHS, in comparison with other available treatments. NICE has not yet issued guidance for the NHS.

Gilenya, or fingolimod, is a daily capsule that could reduce relapses in ...
Read more : Gilenya fails to win NICE backing in draft guidance | Views : 1054 | Replies : 0


Day 4 on Gilenya

I started Gilenya on Saturday. I don't know what I was expecting. I was a little fatigued the first couple of days. Other than that nothing has happened, good or bad. Just a not for anyone interested in starting.
Read more : Day 4 on Gilenya | Views : 3427 | Replies : 4


My experiences, now on Gilenya

First a little context / history.

I have had 3 CCSVI procedures, with little to no relief. I have tried ABX's, I was initially on REBIF, which failed for me. I have had MS Symptoms for around 15 years, with a diagnosis of MS for the past 8 years. I have two neurologists, with one saying SPMS, and the other saying RR. My EDSS is about 4.0 or higher. I can walk just over 1km. ...
Read more : My experiences, now on Gilenya | Views : 3825 | Replies : 3


Gilenya and LDN

Hi, to the forum:

Has anyone been thinking of taking both Gilenya and LDN?
Does anyone know if there are contraindications?
What a dilemma*
I would love to talk about it

Regards everyone.
Read more : Gilenya and LDN | Views : 3992 | Replies : 3


Gilenya® shows up to 71% reduction in relapse rates

Oral MS drug Gilenya® shows up to 71% reduction in annualised relapse rates

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Novartis will showcase data from 13 abstracts on fingolimod (Gilenya®), at the 5th Joint Triennial Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) taking place from 19-22 October in Amsterdam.

The data being presented for fingolimod at ECTRIMS/ACTRIMS highlight the Novartis clinical trial program for ...
Read more : Gilenya® shows up to 71% reduction in relapse rates | Views : 995 | Replies : 0


Japan approves Novartis’ oral MS drug Gilenya

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Japanese regulatory authorities have approved Novartis’ once-daily multiple sclerosis (MS) drug Gilenya.

The Gilenya sanction covers use of the drug for preventing relapse and delaying progression of physical disability in adult MS patients.

The only other drug licensed in Japan for preventing relapse of MS patients is interferon beta. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1309
Read more : Japan approves Novartis’ oral MS drug Gilenya | Views : 849 | Replies : 0


Gilenya, may increase risk of macular edema in some patients

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The first U.S. Food and Drug Administration-approved oral medication for multiple sclerosis poses a potential risk of macular edema, particularly in patients with a history of uveitis, according to a neuro-ophthalmologist.

MS patients who receive Gilenya (fingolimod, Novartis) should undergo baseline and follow-up examinations 3 to 4 months after initiation of treatment, Robert C. Sergott, MD, said at the Wills Eye Institute Alumni Conference in Philadelphia.

“The macular edema issue is one that we ...
Read more : Gilenya, may increase risk of macular edema in some patients | Views : 1758 | Replies : 1


First oral MS drug, Gilenya, rejected by NICE

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Campaigners have expressed disappointment after the National Institute for Health and Clinical Excellence (Nice) rejected the first pill to treat multiple sclerosis.

The MS Society urged the medicines watchdog and drug firm Novartis to work together so that Gilenya – also called fingolimod – can be reappraised.

In draft guidance which is subject to consultation, Nice rejected the drug due to "uncertainties" over its effectiveness, a lack of appropriate data and concerns over cost-effectiveness. ...
Read more : First oral MS drug, Gilenya, rejected by NICE | Views : 1626 | Replies : 3


FDA approves sNDA for Novartis’ oral MS drug Gilenya

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Novartis Pharmaceuticals Corporation announced that the U.S. Food and Drug Administration’s approval of a supplemental New Drug Application (sNDA) for Gilenya™ (fingolimod) that includes T1 Gd-enhancing magnetic resonance imaging (MRI) data. Gilenya is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS) in adults. It can decrease the number of MS flare-ups (relapses). It does not cure MS but can help slow down the physical problems that MS causes.

T1 Gd-enhancing ...
Read more : FDA approves sNDA for Novartis’ oral MS drug Gilenya | Views : 867 | Replies : 0


 

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